Mouse genetics: risk and individual variation: Project P001

Diagram of P001's connections with the other core projects

Project Leader: Tamara Phillips

The use of mice to study genetic risk for alcohol (ethanol; EtOH) consumption and genetic factors that determine EtOH responses have been long-term strengths of the Portland Alcohol Research Center (PARC), strengths continued in this renewal. Scientific Project P001 is a continuation of a PARC project currently with Dr. Hitzemann as Lead. Based on her appropriate expertise, Dr. Richards (a.k.a., Phillips) assumes the role of Lead, as Dr. Hitzemann transitions to retirement. This project continues to use the heterogeneous stock-collaborative cross (HS-CC) mice as the founding population for selective breeding, with a key focus on individual differences in EtOH consumption that persist after selective breeding for high EtOH preference (preference and consumption are correlated at r=0.90). Dr. Ozburn, Co-I, provides expertise pertinent to the testing of treatment targets nominated from transcriptome analyses and provides resident expertise in transcriptome analysis as Dr. Hitzemann transitions away. Risk for EtOH consumption and remaining individual variation in consumption after directional selection may involve different genes and gene networks. Our studies will address this and examine new targets (from the PARC perspective) for manipulating EtOH intake that emerged from our transcriptome research –the extracellular matrix (ECM) and the primary cilium.