Saurabh Thosar Lab

Saurabh Thosar Lab
L to R: Meera Bhide, Saurabh Thosar, Katie Stubbers (Oct. 2019)

About Dr. Thosar

Dr. Saurabh S. Thosar received a professional bachelor’s degree in Occupational Therapy from Seth G.S. Medical College & King Edward Memorial Hospital in India, a clinical master’s degree in Movement Sciences from the University of Illinois at Chicago, and a Ph.D. in Human Performance (Physiology) from Indiana University Bloomington. His clinical background is in the fields of cardiac rehabilitation, and occupational therapy. In Dr. Janet Wallace’s laboratory at Indiana University, Dr. Thosar studied vascular function in response to various stressors, mainly physical inactivity. As a postdoctoral fellow in Dr. Shea’s laboratory at the Oregon Health & Science University, he studied circadian and sleep based mechanisms affecting the cardiovascular system, especially the vascular endothelium.  

Research interests

Dr. Thosar’s current research program is based on his experiences both at Indiana University and at OHSU, and include investigating the mechanisms by which common behaviors (e.g. physical in/activity, food intake, and sleep), and the circadian system affect vascular endothelial function in health and in disease. The long-term goal is to inform and develop improved preventative (e.g., physical activity), and remedial (chronotherapy) countermeasures against cardiovascular disease. Current projects include: 1) Understanding the effects of chronic sedentary behavior on cardiovascular function, and sleep; 2) Investigating circadian rhythms in coronary microvascular function; and 3) Identifying the mechanisms by which blood pressure is regulated during sleep.

Dr. Thosar is a member of the Clinical Physiology and Chronobiology Program and works closely with Drs. Shea, McHill, and Bowles.

Publications

  • Thosar S.S., Berman AM, Herzig MX, McHill AW, Bowles NP, Swanson CM, Clemons NA, Butler MP, Clemons AA, Emens JS, Shea SA. (2019). Circadian Rhythm of Vascular Function in Midlife Adults. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312682. PMID 31070470 DOI: 10.1161/ATVBAHA.119.312682
  • Thosar S.S., Rueda JF, Berman AM, Lasarev MR, Herzig MX, Clemons NA, Roberts SA, Bowles NP, Emens JS, Ellison DH, Shea SA. (2018). Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 30521366 DOI: 10.1152/ajpregu.00314
  • Thosar, S. S., Berman, A. M., Herzig, M. X., Roberts, S. A., Lasarev, M. R., Shea, S. A. (2018). Morning impairment in vascular function is unrelated to overnight sleep or the inactivity that accompanies sleep. American Journal of
    Physiology-Regulatory, Integrative and Comparative Physiology. Accepted for publication.
  • Thosar, S. S., Herzig, M. X., Roberts, S. A., Berman, A. M., Clemons, N. A., McHill, A. W., Bowles, N. P., Morimoto,
    M., Butler, M. P., Emens, J. S., Shea, S. A. (2018). Lowest perceived exertion in the late morning due to effects of the
    endogenous circadian system. Epub ahead of print pii: bjsports-2018-099148. PMID: 29475839
  • Thosar, S. S., Butler, M. P., Shea, S.A. (2018). Role of the circadian system in cardiovascular disease: a double-edged
    sword. Journal of Clinical Investigation, 128(6):2157-2167. PMID: 29856365
  • Thosar, S. S., Niederhausen, M., Lapidus, J., et al. (2017). Self-regulated use of a wearable activity sensor is not
    associated with improvements in physical activity, cardiometabolic risk or subjective health status British Journal of
    Sports Medicine. Epub ahead of print. doi: 10.1136/bjsports-2017-098512. PMID: 29222201
  • Parthasarathy, S., Carskadon, M. A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E.,
    Hart, C. N., Hasler, B. P., Honaker, S. M., Hertenstein, E., Kuna, S., Kushida, C., Levenson, J. C., Murray, C., Pack, A.
    I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P., Thosar, S. S., Williams, N., Buysse, D. (2016). Implementation of
    Sleep and Circadian Science: Recommendations from the Sleep Research Society and National Institutes of Health
    Workshop. SLEEP. 39(12): 2061–2075. PMID: 28201795
  • Berman, Alec M., Thosar, S. S. & Shea, S. A. (2016). Are we underestimating the lifelong benefits of therapy for
    obstructive sleep apnea? Nature and Science of Sleep. 8: 87. PMID: 27051325
  • Thosar S. S., Wiggins, C. C., Shea, S. A, Wallace, J. P. (2015). Brachial artery endothelial function is stable across the
    morning hours in young men. Cardiovascular Ultrasound. 13: 42. PMID: 26438100
  • Thosar, S.S., Bielko, S., Mather, K., Johnston, D., Wallace, J. (2015). Effect of prolonged sitting and breaks in sitting
    time on endothelial function. Medicine and Science in Sports and Exercise. 47(4):843-849. PMID: 25137367
  • Thosar, S. S., Bielko, S. L., Wiggins, C. C., Klaunig, J. E., Mather, K. J., Wallace, J. P. (2015). Antioxidant Vitamin C
    prevents the decline in endothelial function during sitting. Medical Science Monitor. 21: 1015–1021. PMID: 25848890
  • Thosar, S. S., Bielko, S. L., Wiggins, C. C., Wallace, J. P. (2014). Differences in brachial and femoral artery responses
    to prolonged sitting. Cardiovascular Ultrasound. 12:50. PMID 25512175