Taitea Dykstra

Taitea Dykstra profile picture

Current Program Year: MS 1
M.D./Ph.D. Program Students, School of Medicine


Research: neuroimmunology, neurodegenerative disorders, meningeal lymphatics

Clinical: neurology, neurological surgery, physical medicine + rehab, movement disorders

Education and training

B.A., 2010, University of Washington
B.S., 2010, University of Washington 
M.P.H., 2019, George Washington University 
M.S., 2020,  New York University

Memberships and associations:

  • American Medical Association
  • Oregon Medical Association
  • American Physician Scientist Association

Additional information

Honors and awards

Best Thesis Defense, 2020


Selected publications

Salvador, A.R., Dykstra, T., Rustenhoven, J., Gao, W., Blackburn, S., Dong, M., Guimaraes, R., Gonuguntla, S., Smirnov, I., Herz, J., & Kipnis, J. (2023). Age-associated immune and lymphatic responses after spinal cord injury. Neuron, 111(14). doi:10.1016/j.neuron.2023.04.011

Rustenhoven, J., Pavlou, G.*, Storck, S.*, Dykstra, T., Du, S., Wan, Z., Quintero, D., Skalan, J., Smirnov, I., Kamm, R.D., & Kipnis, J. (2023). Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. Journal of Experimental Medicine, 220(7). doi:10.1084/jem.20221929

Drieu, A., Du, S.*,Storck, S. E.*, Rustenhoven, J.*, Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Dominantly Inherited Alzheimer Network, Bateman, R., Perrin, R., Farlow, M., Chhatwal, J., Hu, S., Randolph, G. J., … Kipnis, J. (2022). Parenchymal border macrophages regulate CSF flow dynamics. Nature, 611(7936). doi:10.1038/s41586-022-05397-3

Goldman, D. H., Dykstra, T., Smirnov, I., Blackburn, S., Da Mesquita, S., Kipnis, J., & Herz, J. (2022). Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation. Nature Aging, 2(8). doi:10.1038/s43587-022-00268-y

Sadick, J.S., O’Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. (2022). Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease. Neuron, 110(11). doi:10.1016/j.neuron.2022.03.008

Mazzitelli Perez, J.*, Smyth, L.*, Cross, K., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. (2022). Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels. Nature Neuroscience, 25(5). doi:10.1038/s41593-022-01029-1

Cugurra, A.*, Mamuladze, T.*, Rustenhoven, J.*, Dykstra, T., Beroshvili, G., Greenberg, Z., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., Kanamori, M., Brioschi, S., Schuettpelz, L., Herz, J., Colonna, M., Smirnov, I., & Kipnis, J. (2021). Skull and vertebral bone marrow are myeloid reservoirs for meninges and CNS parenchyma. Science, 373(6553). doi:10.1126/science.abf7844

Da Mesquita, S., Papadopoulos, Z.*, Dykstra, T.*, Brase, L.*, Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., Alves de Lima, K., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., … Kipnis, J. (2021). Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature, 593(7858). doi:10.1038/s41586-021-03489-0

Rustenhoven, J., Drieu, A.*, Mamuladze, T.*, de Lima, K. A.*, Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., … Kipnis, J. (2021). Functional characterization of the dural sinuses as a neuroimmune interface. Cell184(4). doi:10.1016/j.cell.2020.12.040