Biography

Research: neuroimmunology, neurodegenerative disorders, meningeal lymphatics

Clinical: neurology, neurological surgery, physical medicine + rehab, movement disorders

Selected publications

Salvador, A.R., Dykstra, T., Rustenhoven, J., Gao, W., Blackburn, S., Dong, M., Guimaraes, R., Gonuguntla, S., Smirnov, I., Herz, J., & Kipnis, J. (2023). Age-associated immune and lymphatic responses after spinal cord injury. Neuron, 111(14). doi:10.1016/j.neuron.2023.04.011

Rustenhoven, J., Pavlou, G.*, Storck, S.*, Dykstra, T., Du, S., Wan, Z., Quintero, D., Skalan, J., Smirnov, I., Kamm, R.D., & Kipnis, J. (2023). Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. Journal of Experimental Medicine, 220(7). doi:10.1084/jem.20221929

Drieu, A., Du, S.*,Storck, S. E.*, Rustenhoven, J.*, Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Dominantly Inherited Alzheimer Network, Bateman, R., Perrin, R., Farlow, M., Chhatwal, J., Hu, S., Randolph, G. J., … Kipnis, J. (2022). Parenchymal border macrophages regulate CSF flow dynamics. Nature, 611(7936). doi:10.1038/s41586-022-05397-3

Goldman, D. H., Dykstra, T., Smirnov, I., Blackburn, S., Da Mesquita, S., Kipnis, J., & Herz, J. (2022). Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation. Nature Aging, 2(8). doi:10.1038/s43587-022-00268-y

Sadick, J.S., O’Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. (2022). Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease. Neuron, 110(11). doi:10.1016/j.neuron.2022.03.008

Mazzitelli Perez, J.*, Smyth, L.*, Cross, K., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. (2022). Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels. Nature Neuroscience, 25(5). doi:10.1038/s41593-022-01029-1

Cugurra, A.*, Mamuladze, T.*, Rustenhoven, J.*, Dykstra, T., Beroshvili, G., Greenberg, Z., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., Kanamori, M., Brioschi, S., Schuettpelz, L., Herz, J., Colonna, M., Smirnov, I., & Kipnis, J. (2021). Skull and vertebral bone marrow are myeloid reservoirs for meninges and CNS parenchyma. Science, 373(6553). doi:10.1126/science.abf7844

Da Mesquita, S., Papadopoulos, Z.*, Dykstra, T.*, Brase, L.*, Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., Alves de Lima, K., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., … Kipnis, J. (2021). Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature, 593(7858). doi:10.1038/s41586-021-03489-0

Rustenhoven, J., Drieu, A.*, Mamuladze, T.*, de Lima, K. A.*, Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., … Kipnis, J. (2021). Functional characterization of the dural sinuses as a neuroimmune interface. Cell, 184(4). doi:10.1016/j.cell.2020.12.040