Braden Lobingier, PhD - We focus on one of the most prevalent drug targets in the human body, G protein-coupled receptors, and study this family of proteins with approaches ranging from chemical biology and genomics to in vitro reconstitution and proteomics.

Liman Zhang, PhD - We are interested in understanding the molecular mechenism of NLR (Nucleotide-binding domain and leucine rich repeat containing protein) signaling pathways in the immune system. NLR comprise a fascinating family that plays key roles in many immunological pathways from inflammation, anti-viral responses to gene transcription. We combine crystallography, cryo-EM techniques with biochemical and biophysical approaches to address the structural basis behind these functions, aim to provide fundamental knowledge that enables therapeutic applications to treat inflammatory diseases, immunodeficiency disorders, and cancer.