Research updates

AHA International Stroke Conference 2023

Congratulations to Drs. Hung Nguyen, Martin Pike, and Selva Baltan, who were invited to present a poster at the AHA International Stroke Conference 2023 titled “Preconditioning White Matter Against Ischemic Injury; a translational approach.” In brief, they established the in vivo selective white matter injury model in mice and correlated behavior deficits. Additionally, they show that the injury can be seen with MRI imaging and that precondition with Ck2 inhibitor is protective against the injury. 

Congratulations to Dr. Kirk Lalwani on his paper entitled Diversity, equity, and inclusion within the Society of Pediatric Anesthesia: A mixed method assessment, which was recently published in Pediatric Anesthesiology. 

Congratulations to Drs. Nabil Alkayed and Thierno Madjou Bah for being invited to speak at the American Heart Association (AHA) International Stroke Conference this week in Dallas, Texas. Madjou’s talk is titled “Pericyte Heterogeneity and Phenotypic Transformation After Stroke” and will be part of a symposium titled: “High-Dimensional Single Cell Analyses to Unravel the Complexities of Cerebrovascular Disease and Brain.” Nabil’s talk is titled “Introduction to Drug Development from Lab to Clinic” and will be part of a session titled “Concept to Cure: Translating Your Ideas into Therapies.”

Congratulations to Dr. Dayle Hodge for the publication of his manuscript, MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state, in the very prestigious journal Nature Cell Biology. In this important study, which may serve as the catalyst for the creation of targeted therapeutics for breast cancer, Dr. Hodge and collaborators show that a mutation of an epigenetic regulator (MLL3) promotes metastasis in breast cancer. Dr. Hodge designed the CRISPR reagents for this study. CRISPR is an acronym for short DNA sequences that are commonly found in single-cell organisms. This manuscript combined with Dr. Hodge’s current FAER grant-supported work with tissue engineering and revascularization shows that he is one of the most promising young academic anesthesiologists in the country. 

Congratulations to Dr. Catherine “Kasia” Davis who has been appointed to the Topical Advisory Panel Member in IJMS. She has also been appointed a Special Issue Editor for IJMS titled Molecular Mechanisms of Endothelial Dysfunction, which, after a successful 1st edition, is seeking new submissions for the 2nd edition

Congratulations to Drs. Catherine “Kasia” Davis and Nabil Alkayed for the publications of their book chapter in “Advances in Pharmacology” titled Cytochrome P450-derived eicosanoids in brain: From basic discovery to clinical translation. This chapter summarizes the role of cytochrome P450-derived eicosanoids, and their synthetic and metabolizing enzymes, in brain health and disease, focusing on experimental and clinical studies targeting these pathways in brain disorders. Also discussed is the diagnostic utility of quantifying P450 eicosanoids and their enzymes as disease biomarkers.

Further congratulations to Drs. Catherine “Kasia” Davis, Wenbin Zhu, Zhiping “Jim” Cao, Nabil J. Alkayed, and colleagues for their publication in  “Ultrasound in Medicine & Biology” titled Low-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion. This paper describes their studies using therapeutic ultrasound in a mouse model of ischemic stroke. The study shows that non-invasive transcranial ultrasound reduces ischemic brain injury and regulates brain eicosanoids and eNOS phosphorylation. The study suggests that therapeutic ultrasound may be a promising therapeutic modality in the treatment of stroke.