New Publications

Congratulations to Dr. Dayle Hodge on his publication, MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state, in the high-impact Nature Cell Biology. This publication came from his PhD work where he designed the CRISPR reagents for the study. The study examines a mutation of an epigenetic regulator (MLL3) in breast cancer. These results uncovered MLL3 mutation as a key driver of metastasis in breast cancer that could be targeted therapeutically.

Congratulations to Natasha Warikoo, MD/PhD student in the Schnell Lab, for her successfully funded training grant from the NIH NINDS for her study Functional roles of endogenous opioid peptides in hippocampal circuitry. Endogenous opioids control neuronal excitability at circuits throughout the brain and may provide a mechanism for limiting excitation in the hippocampus, specifically in the epileptic brain. In the study, Natasha’s aim is to characterize the impact of endogenous release of opioid peptides on brain network function and improve our understanding of the influence of endogenous opioids on hippocampal circuits to generate new solutions for improved epilepsy management. Nice work Natasha!

Congratulations to Drs. Nabil Alkayed and Thierno Madjou Bah, for the acceptance of their manuscript, Fluid dynamics in aging-related dementias, published in the February 2023 issue of Neurobiology of Disease. This work provides an overview of the glymphatic and dural meningeal lymphatic systems, reviews current methods and approaches used to study glymphatic flow in humans and animals, and discusses current evidence and controversies related to its role in CNS flow homeostasis under physiological and pathophysiological conditions. Non-invasive imaging approaches are needed to fully understand the mechanisms and pathways driving fluid movement in CNS and their roles across the lifespan including healthy aging and aging-related dementia.

Congratulations to Drs. Michael Hutchens, Jessica Hebert, and Yoshio Funahashi for the acceptance of their manuscript, Harm! Foul! How acute kidney injury SHReDDs patient futures, recently published online for Current Opinion in Nephrology and Hypertension. In this paper, the authors thoughtfully review evidence for an associated transition from acute kidney injury to chronic other-organ diseases such as stroke, hypertension, reproductive risk, dementia, and death (SHReDD).

Dr. Michael Hutchens also coauthored Soluble ACE2 is filtered into the urine, which was published in Kidney360 last month. This article describes how investigators conducted bilateral renal cross-transplantation to show the relative contribution of renal ACE2 to the pathogenesis of AngII-mediated hypertension.