2011-2012 Series



Thursday, August 11, 2011

Special Seminar: When ion channel meets transporter: Structure and mechanism of a eukaryotic CLC transporter

Liang Feng, Ph.D.
Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY
Host: Eric Gouaux

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October 6, 2011

Phenotypic analysis at single-cell resolution in vivo: The application of mouse genetic mosaic system to brain tumor biology

Hui Zong, Ph.D.
Institute of Molecular Biology, University of Oregon, Eugene
Host: Dick Goodman

October 13, 2011

Melanopsin signaling in the eye

King-Wai Yau, Ph.D.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD
Host: Tianyi Mao

October 20, 2011

Molecular constituents of excitatory synaptic transmission in the brain

Susumu Tomita, Ph.D.
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT
Host: Eric Gouaux

October 27, 2011

Neural signal integration in dendrites and axons in the hippocampus

Nelson Spruston, Ph.D.
Scientific Program Director and Laboratory Head, HHMI Janelia Farm Research Campus, Ashburn, VA
Host: John Adelman

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November 3, 2011

Substrate-modulated gating dynamics in a sodium-coupled transporter

Scott Blanchard, Ph.D.
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY
Host: Eric Gouaux

November 17, 2011

The influences of synaptic frequency and glutamate transport on NMDA receptor signaling

Michael Kavanaugh, Ph.D.
Department of Biomedical and Pharmaceutical Sciences,
The University of Montana, Missoula, MT
Host: Craig Jahr

November 28, 2011

Astrocytes, regulated exocytosis, vesicle traffic and fusion pore properties

Robert Zorec, Ph.D.
Institute of Pathological Physiology, University of Ljubljana, Slovenia
Host: Henrique von Gersdorff and Stephen Smith

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December 1, 2011

Synaptic mechanisms underlying the circuit function in the mammalian retina

Joshua Singer, Ph.D.
Departments of Ophthalmology and Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Host: Henrique von Gersdorff

December 5, 2011

Joint Seminar with the Jungers Center: In vivo multiphoton calcium imaging of neuronal and astrocytic networks in mouse models of disease

Kishore Kuchibhotla, Ph.D.
Harvard University, Cambridge, MA
Host: Vivek Unni

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February 2, 2012

Molecular mechanisms underlying the establishment of neuronal connectivity

Alex Kolodkin, Ph.D.
HHMI, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD
Host: Tianyi Mao

February 9, 2012

Optogenetics, robotic electrophysiology, and other neuroscience tools

Ed Boyden, Ph.D.
MIT Media Lab, McGovern Institute, Depts. of Brain & Cognitive Sciences and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA
Host: Gary Westbrook

February 16, 2012

Joint Seminar with Physiology & Pharmacology:
Active trans-membrane water cycling: High-resolution NMR detection of life

Charles Springer, Ph.D.
Advanced Imaging Research Center, Knight Cancer Institute, Department of Biomedical Engineering, OHSU, Portland, OR
Host: David Dawson

February 23, 2012

Peptides, peptidases, and peptidomics: New insights into inter- and intracellular signaling

Lloyd Fricker, Ph.D.
Departments of Molecular Pharmacology and Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY
Host: Gary Thomas

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MARCH 2012

March 1, 2012

Zinc-mediated synaptic signaling: The role of zinc as a neurotransmitter

Thanos Tzounopoulos, Ph.D.
Departments of Otolaryngology and Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA
Host: John Adelman

March 8, 2012

The structure of a GPCR-G protein complex: Insights into the mechanism of hormone-activated nucleotide exchange

Roger Sunahara, Ph.D.
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI
Host: John Williams

March 13, 2012

Joint Special Seminar with OHSU Nephrology & Hypertension: Deconstructing the machine: Understanding complex traits using extreme outliers

Richard P. Lifton, M.D., Ph.D.
HHMI, Departments of Genetics and Internal Medicine, Yale University School of Medicine, New Haven, CT
Host: Dick Goodman David Ellison

March 15, 2012

Regulation of cell death by the Bcl-2 family member Mcl-1

Gordon Shore, Ph.D.
Department of Biochemistry, Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
Host: Gary Thomas

March 30, 2012

Tom Soderling Symposium: A Career in Calcium Signaling

Session I: Intracellular Signaling

John Scott, Ph.D., Cell signaling in space and time
Gary Banker, Ph.D., Microtubule-based motors in neuronal polarity
Randy Hall, Ph.D., Signaling by adhesion G protein-coupled receptors
Hervé Enslen, Ph.D., Tyrosine kinases move from the regulation of cell adhesion to pathogen invasion
Scott Soderling, Ph.D., Actin badly: Modeling disorders associated with abnormal synaptic cytoskeletal signaling
Gary Wayman, Ph.D., Neurotrophic actions of leptin: Local and genetic control of synaptogenesis

Session II: Ca2+-CaM Kinases

Hiroshi Tokumitsu, Ph.D., CaMKK: From enzyme to inhibitor
Takeo Saneyoshi, Ph.D., Functional phospho-proteomics analysis of cellular substrates for CaMKI
Roger Colbran, Ph.D., Modulation of CaMKII by CaMKII-associated proteins
Andres Barria, Ph.D., Trafficking and function of NMDA receptors
Johannes Hell, Ph.D., Role of CaMKII binding to the NMDAR subunit GluN2B in LTP and memory consolidation
John Lisman, Ph.D., CaMKII: a memory molecule

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APRIL 2012

April 5, 2012

The role of KSR and RAF kinases in the MAP kinase signaling pathway

Andrey Shaw, M.D.
HHMI, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO
Host: Phil Stork

April 16, 2012

Special Seminar: The emergence of response selectivity in primary visual cortex

Nicholas Priebe, Ph.D.
Section of Neurobiology, School of Biological Sciences, The University of Texas at Austin
Host: Neuroscience Graduate Program and Henrique von Gersdorff

April 17, 2012

Jungers Center Seminar: The changing face of Alzheimer's disease: From early onset families in Colombia to rethinking the basics

Kenneth Kosik, M.D.
Department of Molecular, Cellular and Developmental Biology
University of California, Santa Barbara
Host: Gary Westbrook and the 2012 Neurobiology of Disease Course

April 19, 2012

Bidirectional synaptic plasticity expressed by NMDA receptors

Pablo Castillo, M.D., Ph.D.
Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY
Host: Craig Jahr

April 26, 2012

Mice, men, and microscopes: Visualizing the dynamics of the neuronal orchestra in awake behaving animals

Mark Schnitzer, Ph.D.
HHMI, Department of Biological Sciences, Department of Applied Physics, Stanford University, Stanford, CA
Host: Teresa Nicolson

April 27, 2012

Special Seminar: Growth control and growth-dependent cell cycles in Drosophila

Bruce A. Edgar, Ph.D.
German Cancer Research Center (DKFZ)–Center for Molecular Biology Heidelberg (ZMBH) Alliance, Heidelberg, Germany
Host: Dick Goodman

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MAY 2012

May 10, 2012

Mechanisms of motor control and reinforcement learning in the basal ganglia

Anatol Kreitzer, Ph.D.
Gladstone Institute of Neurological Disease, Depts. of Physiology and Neurology, University of California, San Francisco
Host: Larry Trussell

May 15, 2012

Jungers Center Seminar: Mitochondrial dynamics and axon degeneration

Robert H. Baloh, M.D., Ph.D.
Dept. of Neurology: Neuromuscular Medicine, ALS Program, Cedars-Sinai Medical Center, Los Angeles, CA
Host: Gary Westbrook and the 2012 Neurobiology of Disease Course

May 17, 2012

Herbert Memorial Lecture: Novel neural messengers of life and death

Solomon H. Snyder, M.D.
The Solomon H. Snyder Department of Neuroscience,
Johns Hopkins University School of Medicine, Baltimore, MD
Host: Dick Goodman

May 18, 2012

Special Seminar: Synaptic circuit organization of mouse motor cortex

Gordon M. G. Shepherd, M.D., Ph.D.
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL
Host: Neuroscience Graduate Program and Henrique von Gersdorff

May 18, 2012

Special Seminar: Native AMPA receptors in the mammalian brain: Insights and surprises from high resolution proteomics

Bernd Fakler, M.D.
Institute of Physiology, University of Freiburg, Freiburg, Germany
Host: John Adelman

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JULY 2012

Friday, July 27, 2012

Special Seminar: Spatiotemporal dynamics of opioid neuropeptide signaling in the mammalian brain

Matthew Banghart, Ph.D.
Department of Neurobiology, Harvard Medical School, Boston, MA
Host: John Williams

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