Study shows promise in repairing damaged myelin

Tom Scanlan and Meredith Hartley discuss research

scientific breakthrough provides new hope for millions of people living with multiple sclerosis. Researchers at OHSU have developed a compound that stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord.

The discovery, involving mice genetically engineered to mimic multiple sclerosis, published today in the journal JCI Insight.

“There are no drugs available today that will re-myelinate the de-myelinated axons and nerve fibers, and ours does that,” said senior author Tom Scanlan, Ph.D., professor of physiology and pharmacology in the OHSU School of Medicine.

Members of the Department of Biochemistry and Molecular Biology and the Department of Physiology and Pharmacology

Two basic science departments to join

SoM leverages expertise, technology and fresh investment to form new, expanded department

Dean Sharon Anderson approved a proposal to combine two basic science departments in the OHSU School of Medicine to form a new, expanded department starting July 1.

The Department of Biochemistry and Molecular Biology and the Department of Physiology and Pharmacology will join together to leverage faculty specialties and technology. Read more.

Highlighted publication: Valiyaveetil lab

"Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor"

In this study, the Valiyaveetil group (in collaboration with the Ahern group at U of Iowa) used advanced chemical biology approaches to investigate the role of backbone hydrogen bonds in the voltage sensing transmembrane helix of a eukaryotic potassium channel.  The study provides key insights into the physiologically important process of voltage gating in ion channels and establishes a methodology for probing backbone hydrogen bonds, which opens new possibilities for investigating membrane proteins.

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