Welcome from the chair

Dr. Susan Hayflick

Biochemistry underpins many of the basic biomedical sciences, from molecular genetics to immunology and pharmacology.  Biochemists identify the molecular players in cellular function and their mechanisms of action. Students in the Department of Biochemistry and Molecular Biology come to learn, in atomic detail, about the molecular interactions common to basic life processes, and the techniques that illuminate the molecular underpinnings of normal physiology and the diseased state.  Our faculty are experts in the methods of molecular genetics, protein biochemistry, enzymology, x-ray crystallography, mass spectrometry and electron microscopy.  Application areas range widely from the genetic causes of cancer, to protein synthesis and modification, to cell communication, signal transduction and the metabolic pathways of parasites, viral cell entry, and to the fundamentals of bio-molecular structure and dynamics. Learn more about our department.

Selected publications

Babur Ö, Ngo ATP, Rigg RA, Pang J, Rub ZT, Buchanan AE, Mitrugno A, David LL, McCarty OJT, Demir E, Aslan JE. Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis. Am J Physiol Cell Physiol. 2018 May 1;314(5):C603-C615. Epub 2018 Feb 7. PubMed PMID: 29412690.

Hulett TW, Jensen SM, Wilmarth PA, Reddy AP, Ballesteros-Merino C, Afentoulis ME, Dubay C, David LL, Fox BA. Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer. 2018 Apr 5;6(1):27. PubMed PMID: 29618380.

Hosseini MM, Kurtz SE, Abdelhamed S, Mahmood S, Davare MA, Kaempf A, Elferich L, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JW, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia. 2018 Mar 29; PubMed PMID: 29743719.

Smith JR, David LL, Appukuttan B, Wilmarth PA. Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs. Am J Ophthalmol. 2018 Mar 17; PubMed PMID: 29559410.

Platt, E, Smith, L, Thayer, ML1 retrotransposon antisense RNA within ASAR IncRNAs controls chromosome-wide replication timing. J of Cell Biology. 2017 Dec 29; DOI: 10.1083/jcb.201707082.

Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng S-LAnti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM. eLife. 2017 Oct 24; 6:31054.

Boswell BA, Korol A, West-Mays JA, Musil LSDual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017 Apr 1;28(7):907-921. PubMed PMID: 28209733.

Martin GM, Yoshioka C, Rex E, Fay J, Xie Q, Whorton MR, Chen JZShyng S-LCryo-EM structure of the ATP-sensitive potassium channel  illuminates mechanisms of assembly and gating. eLife. 2017 Jan 16; 6:e24149.

Featured research

Delayed Replication: "BrdU Terminal Label Assay"

News

Haley Licon (Yates Lab), one of BMB's graduate students, won the "best technique award" for her poster at the PMCB retreat last month. The title was "Post-transcriptional regulation of the NT3 purine nucleobase transporter is mediated by a repressive stem loop in the NT3 3' mRNA untranslated region during the Leishmania donovani purine stress response." Congratulations, Haley!

Using single-particle cryo-electron microscopy, investigators Sigrid Noreng and Rich Posert, BMB graduate students in the Baconguis lab, published the first visual representation of a protein connected to several diseases. Check out the article in OHSU Research News or in the journal eLife.

Please join us in congratulating David Farrens on his recent promotion to Professor. He was one of 120 faculty members from 25 of the School of Medicine's 27 departments, and one of only 24 to be promoted to Professor. Congratulations, Dave! You can read more about David's promotion!

Check out this fun and informative interview with Greg Martin (Shyng Lab), Eric Gouaux(affiliate BMB faculty member and Senior Scientist in the Vollum Institute) and Craig Yoshioka (Gray Lab, OCSSB) on OPB, in which they discuss the new $128M NIH grant to build four new cryo-electron microscopes here at OHSU. This grant is poised to make the university into a nationally recognized imaging center - one of only three in the country - when the microscopes are installed this fall.

The Department of Biochemistry is proud to announce that PhD student Veronica Cochrane (Shyng Lab) is the recipient of a 2018 N.L. Tartar Trust Grant. The award is for $2,000 to fund research service and supply. Congratulations Veronica!

Congratulations to Raj Shah, BMB Grants & Contracts Coordinator, for his selection as an associate trainer with the OHSU Unconscious Bias campus-wide initiative. Raj will participate in a week-long training process in August and then will be responsible for leading unconscious bias trainings all over campus over the next year.

The BMB department would like to celebrate and honor the following team members for their many years of service:

Mathew Thayer (Thayer lab) - 25 years of service
Judy VanSlyke (Musil lab) - 15 years of service
Zhongying Yang (Shyng lab) - 15 years of service
Andrew Trzynka (Chapman lab) - 10 years of service