About

The Layton Aging and Alzheimer's Disease Center is one of several dozen NIA Alzheimer's Disease Centers in the U.S. and the only one of its kind in Oregon. Our center is recognized as a national leader in dementia care and research.

Cores

The Administrative Core oversees and sets the research direction for the Layton Center. This Core fosters new and innovative research relevant to brain aging, recruits new investigators, oversees cross-ADC collaborations and multicenter studies, coordinates grant-related activities, and manages financial resources. Working behind-the-scenes, the Administrative Core also acts as a liaison between all the individual Cores and between individual investigators, clinicians, educators and the community.

Director: Dr. Jeffrey Kaye, M.D.

For more information, message Tracy Zitzelberger at zitzelbe@ohsu.edu or call 503-494-7198

The Biomarker Core collects and stores tissue samples, biomarkers, family history data and genotype data from subjects recruited by the Clinical Core. (These can include markers in blood, spinal fluid, patterns of activity on MRI scans or scores on cognitive tests). Biomarker data is prepared and distributed to investigators that are a part of ongoing national research studies, in order to foster collaborative research about neurodegenerative disease.  

Director: Dr. Joe Quinn, M.D.

For more information, message Dr. Joe Quinn, M.D. at quinnj@ohsu.edu or call 503-494-7234 

Learn what type of family history and genotype data the Core collects and learn how to request a biomarker data or tissue sample. View more.

The goal of the Clinical Core is to maintain an active group of research participants, with or without dementia, to support a variety of studies. This group includes the underserved African American senior population. Research coordinators screen research participants, perform clinical tests and facilitate clinical trials and studies. The Core also provides data, biological specimens, and expertise to national data sharing initiatives and approved regional and national investigations.

Director: Dr. Jeffrey Kaye, M.D.

For more information, message Dr. Jeffrey Kaye at kaye@ohsu.edu

The Data Management & Statistics Core receives, stores, and manages, and analyzes data generated by the other Cores and by other research projects at the Layton Center. Investigators within this Core provide guidance on statistical analysis, research study design, sample size estimations, interpretation of study findings and related issues. Working collaboratively with the Neuroimaging, Clinical, Biomarker and Neuropathology Cores, this Core shares clinical cohort data with investigators and maintains secure platforms for data exchange.

Director: Dr. Hiroko Dodge, Ph.D.

For more information, message Nora Mattek M.P.H.

Learn more about the Center's database, see how to make a data request and view requirements for submitting manuscripts for publication. Read more. 

The goal of the Digital Technology Core is to maintain a dementia-focused Life Laboratory, consisting of a group of research volunteers with and without dementia, and make the data available for research. Research volunteers in this Life Laboratory will have state-of-the-art computing platforms installed in their homes. This technology platform includes sensors and smart devices capable of gathering, sharing and sending continuous data about everyday activity. Conventional clinical assessments have limits in their ability to precisely map changes in activity over time. Our research community increasingly seeks methodologies that incorporate continuous, real-world and objective ways to measure key characteristics of daily living (e.g. mobility, cognition, sleep, medication taking, driving), using the computing platform and methodologies developed by ORCATECH (Oregon Center for Aging & Technology).

Director: Dr. Zach Beattie

For more information, please contact Dr. Beattie at beattiez@ohsu.edu

Learn more about ORCATECH’s technology platform and how it analyzes data. View more. 

The Neuroimaging Core focuses on detecting early brain changes associated with cognitive decline and dementia, using the Neuroimaging Laboratory at the Layton Center. Participants undergo MRI, fMRI and PET scans for a wide array of studies. The Laboratory acts as an archival service, managing a library of thousands of digitized scans and other neuroimaging data. Investigators also receive advanced training in imaging techniques.  

Director: Dr. Lisa Silbert, M.D., M.C.R.

For more information, message David Lahna at lahnad@ohsu.edu or call 503-494-1266 

Learn about the current projects at the Neuroimaging Laboratory. View more.

The Neuropathology Core collects, characterizes, and stores brain donations from clinical study participants at the Oregon Brain Bank, in accordance with established protocols. By creating a safeguarded yet accessible repository of brain tissue and neuropathological data, the Core is able to perform diagnostic evaluations of autopsy tissue and facilitate research about brain aging. The Core provides tissue to investigators researching aging and dementia and teaches trainees about current neuropathological classifications of neurodegenerative diseases.   

Director: Dr. Randall Woltjer, M.D., Ph.D.

For more information about the Oregon Brain Bank, message Dr. Randall Woltjer at woltjerr@ohsu.edu or call 503-494-8276

Learn more about tissue requests and the Core's protocols. View more. 

The Outreach, Recruitment and Education Core develops and manages a wide array of programs to increase public awareness and understanding of Alzheimer's disease and research at the Layton Center. One main goal is building relationships with the community and networking with other organizations to provide educational resources and recruit participants for studies, a particular focus being underserved rural communities, low-income populations and minority groups. The Core also organizes meetings, lectures and workshops throughout Oregon and publishes a newsletter twice a year.

Director: Dr. Allison Lindauer, Ph.D., N.P.

For more information, message Natasha Spoden at spoden@ohsu.edu or call 503-494-6370

Learn about the Layton Center's educational programs for the public and health care professionals. View more.


Grant opportunities

The Layton Center offers several pilot grant programs for new investigators or more experienced investigators who have novel ideas that may advance Alzheimer's research.

Pilot research awards

We have three pilot research awards, the Oregon Alzheimer's Disease Center (OADC) Pilot Program, the ORCASTRAIT Roybal Center Pilot Study Program and the Oregon Partnership for Alzheimer's Research (OPAR) grant.

Funds for the OPAR grant have been made available by Oregonians through the Oregon Income Tax Charitable Checkoff Program.

To learn more about these annual awards - including application deadlines, project timelines and how to apply - click on the links.

Oregon Alzheimer's Disease Research Center (OADRC)

Letter of Intent (LOI) Deadline: October 15, 2021 at 5 pm PST
Application Deadline: November 19, 2021 at 5 pm PST
Project Dates: March 1, 2022 - February 28, 2023
Maximum Direct Costs: $75,000
Number of Awards Given: 2

More information: View the grant announcement

Oregon Partnership for Alzheimer's Research (OPAR)

Letter of Intent (LOI) Deadline: October 15, 2021 at 5 pm PST
Application Deadline: February 11, 2022 at 5 pm PST
Project Dates: June 1, 2022 - May 31, 2023
Maximum Direct Costs: $30,000
Number of Awards Given: 2

View the grant announcement
View the guidelines for applying
View the letter of intent application form

ORCASTRAIT Pilot Study Funding

Letter of Intent (LOI) deadline: December 11, 2021
Application deadline: January 14, 2022
Project dates: June 2022 –May 2023
Maximum direct costs: $95,000
Number of awards given: 2

More information: Visit the ORCASTRAIT pilot study funding webpage