2004-2005 Series



September 13, 2004

K Channel Biology: From Structure to Disease

Colin G. Nichols, Ph.D.
Department of Cell Biology and Physiology, Washington University School of Medicine
Host: Ed McCleskey

September 30, 2004

Signaling through protein phosphorylation

Tony Hunter, Ph.D.
The Salk Institute, San Diego, CA
Host: John Scott



October 7, 2004

Autoregulation of synaptic strength in central neurons

Richard Tsien, Ph.D.
Department of Molecular and Cellular Physiology, Stanford
Host: John Adelman

October 14, 2004

Nuclear receptor control of lipid metabolism

David Mangelsdorf, Ph.D.
Professor, Department of Pharmacology,
UT Southwestern Medical Center, Dallas, HHMI Investigator
Host: Dick Goodman

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November 4, 2004

Imaging circuit assembly in the retina

Rachel Wong, Ph.D.
Washington University at Saint Louis
Host: Larry Trussell

November 11, 2004

Stop and go during development: Directing vesicular traffic during synapse formation

A. Kimberly McAllister, Ph.D.
Center for Neuroscience, University of California, Davis
Host: Gary Westbrook

November 18, 2004

Signaling to extrasynaptic receptors in cerebellum

Thomas Otis, Ph.D.
Department of Neurobiology, UCLA Medical School
Host: Craig Jahr

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December 2, 2004

Transcriptional activators, co-factor complexes and disease

Robert Tjian, Ph.D.
Howard Hughes Medical Institute, Molecular & Cell Biology, University of California, Berkeley
Host: Dick Goodman

December 6, 2004

Quantification of transporter protein densities and modelling of transmitter diffusion in a CNS synapse

Knut Petter Lehre, Ph.D.
Department of Anatomy, University of Oslo, Norway
Host: Henrique von Gersdorff

December 9, 2004

Mechanisms Regulating Synaptic Dynamics in Layers 2/3 in the Visual Cortex

Lonnie Wollmuth, Ph.D.
Department of Neurology & Behavior, SUNY, Stony Brook, New York
Host: Henrique von Gersdorff

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February 3, 2005

The Dystrophin Complex: a Membrane Scaffold for Signaling Proteins in Muscle and Brain

Stan Froehner, Ph.D.
Department of Physiology and Biophysics, University of Washington, Seattle
Host: Gary Westbrook

February 10, 2005

Seeing Circuits Assemble

Stephen Smith, Ph.D.
Professor, Molecular & Cellular Physiology, Stanford University
Host: Wolfhard Almers

February 17, 2005

Activity-dependent homeostatic specification of neurotransmitter choice

Nicholas Spitzer, Ph.D.
Biological Sciences, University of California at San Diego
Host: Tom Soderling

February 22, 2005

PRIALT® (ziconotide intrathecal infusion): A newly approved calcium channel blocker to treat severe, chronic pain

George Miljanich, Ph.D.
Research Fellow, Medical Affairs, Elan Pharmaceuticals, San Diego
Host: Ed McCleskey

February 24, 2005

The hyperpolarization-activated pacemaker channel: A gate of learning and memory

Steven Siegelbaum, Ph.D.
HHMI, Department of Pharmacology, Columbia University, New York, NY
Host: John Adelman

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MARCH 2005

March 3, 2005

Protein synthesis at the synapse

Erin Schuman, Ph.D.
California Institute of Technology
Host: Phil Stork

March 10, 2005

Protein interactions

Stan Fields, Ph.D.
Genome Sciences, University of Washington
Host: Mike Forte

March 17, 2005

Shining a light on dendritic integration and synaptic plasticity in the hippocampus with glutamate photolysis

Scott Thompson, Ph.D.
Department of Physiology, University of Maryland, Baltimore, MD
Host: John Adelman

March 31, 2005

The molecular machinery for cAMP-dependent immunomodulation in T cells

Kjetil Taskén, M.D., Ph.D.
Professor, Centre Director, The Biotechnology Centre of Oslo, Norway
Host: John Scott

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APRIL 2005

April 7, 2005

Comparative Kinomics: How Genome Sequences and a Billion Years of Evolution can Help Us Understand Protein Kinases and Cell Signaling

Gerard Manning, Ph.D.
Bioinformatics, Salk Institute for Biological Sciences, San Diego, CA
Host: John Scott

April 8, 2005

Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton

Eric Honoré, Ph.D.
Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice, Sophia-Antipolis, France
Host: John Adelman

April 14, 2005

NHR-49: A C. elegans nuclear hormone receptor that affects lifespan and modulates fat storage, consumption and composition

Keith Yamamoto, Ph.D.
Executive Vice Dean, School of Medicine, UC San Francisco, CA
Host: Dick Goodman

April 21, 2005

Regulating early signaling by antigen receptors

Arthur Weiss, M.D., Ph.D.
HHMI, Department of Microbiology and Immunology, University of California, San Francisco
Host: Phil Stork

April 28, 2005

Phosphoserine/Threonine-Binding Domains: Integrators of Protein Kinase Signaling in Cell Cycle Control and Cancer

Michael Yaffe, M.D., Ph.D.
Associate Professor, Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology
Host: John Scott

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MAY 2005

May 9, 2005

Molecular Control of the Cellular Response to Oxidative Stress

Yuxin Yin, M.D., Ph.D.
Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University

May 12, 2005

The Computational Algorithm of Cerebellar Purkinje Cells

Kamran Khodakhah, Ph.D.
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY
Host: John Williams

May 26, 2005

Regulation of receptor signaling and trafficking by phosphoinositide lipids and ubiquitin

Scott Emr, Ph.D.
HHMI, Cellular and Molecular Medicine, UCSD School of Medicine
Host: Gary Thomas

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JUNE 2005

June 2, 2005

Herbert Memorial Lecture: Oxygen Sensation: Unconventional Signaling for an Unconventional Sense

Cori Bargmann, Ph.D.
HHMI, The Rockefeller University, New York, NY
Host: Dick Goodman

June 3, 2005

Integration of small G protein function

Phil Stork, M.D.
Host: The Vollum Institute

June 16, 2005

MicroRNAs, transcription factors and neuronal development in C. elegans

Oliver Hobert, Ph.D.
HHMI, Department of Biochemistry and Molecular Biophysics, Columbia University, NY
Host: Dick Goodman

June 22, 2005

Gene and Cell Therapy for Parkinson's and Huntington's Disease

Jeffrey H. Kordower, Ph.D.
Director, Research Center for Brain Repair, Division of Neuroscience, Rush University Medical Center, Chicago, IL
Host: Gary Westbrook

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JULY 2005

July 8, 2005

Paved with Good Intentions: The Role of Cell Cycle Events in Neurodegenerative Disease

Karl Herrup, Ph.D.
Director, Alzheimer Research Center, Case Western Reserve University
Hosts: Vollum Institute and the OHSU Department of Neurology

July 28, 2005

Dissecting Synaptic Learning Rules in the Hippocampus

Gayle M. Wittenberg, Ph.D.
Department of Molecular Biology, Princeton University
Host: John Adelman

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