Zhong Lab

Senior Scientist and Principal Investigator: Haining Zhong

Video abstract from our paper in Neuron

Opening graphic from the "A highly sensitive A-kinase activity reporter for imaging neuromodulatory events in awake mice" video abstract in Neuron

"A highly sensitive A-kinase activity reporter for imaging neuromodulatory events in awake mice" appeared in the August 22, 2018 issue of the journal Neuron.

Authors are Lei Ma, Bart C. Jongbloets, Wei-Hong Xiong, Joshua B. Melander, Maozhen Qin, Tess J. Lameyer, Madeleine F. Harrison, Boris V. Zemelman, Tianyi Mao* and Haining Zhong*. (* co-senior authors)

The video is approximately 6 minutes long.

Current lab members

Jiaman Dai head shot
Jiaman Dai (daij AT ohsu.edu)

Ph.D., Chongqing University

Jiaman joined the Zhong Lab in December 2024 as a Senior Research Associate. He earned his Ph.D. in Biomedical Engineering from Chongqing University in 2017. He then completed postdoctoral training in neuroscience at the University of Wyoming, where he studied how the somatosensory cortex processes information during learning. At the Zhong Lab, Jiaman’s research focuses on the intrinsic signaling dynamics of astrocytes and their role in neurotransmitter modulation during learning. Outside the lab, he enjoys fitness and reading.
Dr Helen Guo head shot

Helen/Lanboling Guo (guol AT ohsu.edu)

Ph.D., Nanyang Technological University

Helen joined the Zhong lab in April 2024 as a postdoctoral fellow. She earned her Ph.D. in Neuroscience from the School of Biological Science, Nanyang Technological University in Singapore, where she studied how interneurons in the cerebellum are involved in non-motor functions. She then went to the Lee Kong Chian School of Medicine at the same University, studied cerebellar-related motor control, and tested behaviors and vasculature changes in several disease models. In the Zhong lab, Helen plans to explore the role of PKA in neuronal activities during locomotion with two-photon imaging. Outside the lab, Helen likes cooking and hiking.

Zilong Liu head shot

Zilong Liu (liuzi AT ohsu.edu)

MBBS, Peking University

Zilong joined the Zhong lab in July 2025 as a graduate student. He earned his MBBS in Neurobiology from the School of Basic Medical Sciences at Peking University, where he studies cortical Fos ensemble in memory and nociception. In the Zhong lab, he will investigate the source of striatal purinergic signaling in vivo and how it modulates locomotion. Outside the lab, Zilong enjoys reading and hiking.

Maozhen Qin in the Mao and Zhong Labs

Maozhen Qin (qinm AT ohsu.edu)

Bachelor in Nursing

Maozhen obtained a bachelor's degree in nursing in China and has been working as a research assistant since 2008. She joined the Mao and Zhong labs in 2011 where she quickly became the "go-to" person for genotyping, culturing slices, performing animal surgeries, and maintaining the inventory of lab supplies. She became lab manager in 2014. Outside of work, Maozhen enjoys camping and hiking.

Yinghan Xiao head shot

Yinghan Xiao (xiaoy AT ohsu.edu)

M.S., University of Chinese Academy of Sciences

Yinghan joined the Zhong Lab as a Ph.D. student in December 2024. He earned his bachelor's degree from the Southern University of Science and Technology and his master's degree from the University of Chinese Academy of Sciences, where he focused on fluorescent protein engineering. He developed an intensity-based inositol triphosphate sensor using a novel design strategy. At the lab, his focus is on developing more fluorescent sensors for Fluorescence Lifetime Imaging (FLIM) and applying them in neuroscience research. Outside the lab, Yinghan enjoys hiking, camping, and esports.

Takaki Yahiro head shot

Takaki Yahiro (yahiro AT ohsu.edu)

M.D., Ph.D.

Takaki joined the Zhong lab in October 2023 as a postdoctoral fellow. He received his M.D., Ph.D. from Nagoya University in Japan, where his graduate study focused on the afferent neural pathway for behavioral thermoregulation. He will investigate the PKC-mediated neural modulation in the cortex with a newly improved PKC sensor and in vivo 2-photon lifetime. Outside the lab, Takaki often explores restaurants and tries new cuisines in Portland.

Yizhou Zhuo head shot

Yizhou Zhuo (zhuoy AT ohsu.edu)

Ph.D., Peking University

Yizhou joined Zhong lab in July 2024 as a postdoctoral fellow. She earned her Ph.D. at the School of Life Sciences, Peking University, where her graduate study mainly focuses on the development of genetically-encoded dopamine sensors. Yizhou developed a suite of green and red dopamine sensors that enable sensitive dopamine detection across multiple brain areas and dual-color imaging in combined use with other optical sensors in vivo, which therefore provide a robust tool for better understanding the dopamine system. Yizhou plans to continuously work on tool development but shifting her interest from generating optical sensors for probing extracellular transmission to optical actuators that are able to manipulate intracellular signaling processes. Outside of work, Yizhou enjoys traveling and tasty foods.

Contact information

Lab phone number

503-494-9185

Lab location

Vollum Room 3427 (north)

Faculty support

Teresa Newton

Grants/Contracts Coordinator

Email: newtont@ohsu.edu

Phone: 503-494-5458

Mailing address

Haining Zhong Lab

Vollum Institute, OHSU

3181 SW Sam Jackson Park Rd.

Mail code L474

Portland, OR 97239-3098

Shipping address

Haining Zhong Lab

Vollum Institute, OHSU

3181 SW Sam Jackson Park Rd.

Dock 4, Vollum Rm. 3427

Portland, OR 97239-3098

Vollum Institute

3232 SW Research Drive
Portland, OR 97239

Name Years in Lab Lab Position Current Position
Geng-Lin Li 2011 Research Associate Assistant Professor, University of Massachusetts Amherst
Guang Yang 2011–2012 Postdoc Postdoc, Shriners Hospitals for Children, Portland
Brian Long 2010–2013 Postdoc Scientist II, Allen Institute for Brain Science, Seattle
Shane Tillo 2010–2013 NGP Ph.D. Student Principle Investigator, Montana Molecular, LLC
Sheng Miao 2013–2015 Postdoc Postdoc, Salk Institute for Biological Studies
Dale Fortin 2012–2016 Postdoc Adjunct Faculty, Washington State University at Vancouver
Joshua Melander 2014–2017 Research Assistant Graduate Student, Stanford University
Weihong Xiong 2015–2020 Staff Scientist Data science industry
Crystian Massengill 2018–2021 Sr. Research Assistant Graduate Student, Harvard Program in Neuroscience
Brecklyn Beighle 2023–2025 Research Assistant TI Clinical Research Assistant, OHSU
Tin Long Yiu 2020–2025 NGP Ph.D. Student Postdoctoral Scholar, OHSU