OHSU researchers discover link between key protein and brain synapse development

Dr Kevin Wright and Dr Jennifer Jahncke sit in front of a computer monitor displaying an image from their research
Left to right: Kevin Wright, Ph.D. and Jennifer Jahncke, Ph.D.

Vollum Institute scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the neurological problems experienced by people with a rare form of muscular dystrophy known as dystroglycanopathy.

The research conducted at Oregon Health & Science University and published in Communications Biology reveals that the protein Dystroglycan plays a critical role in forming and maintaining connections between nerve cells in the cerebellum — the part of the brain responsible for movement coordination and motor learning.

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