Current Research

Micronutrients for ADHD in Youth: The “MADDY” Study

The MADDY Study is measuring the effects of a 36-ingredient broad spectrum micronutrient supplement on children, age 6 to 12, who have symptoms of ADHD and irritability or emotional dysregulation. This double-blind, randomized, placebo-controlled trial examines whether the broad spectrum micronutrient formula will be a viable treatment for children with ADHD and irritability, based on parent-, child-, and clinician-rated reports of behavior and functioning. 

An important additional aim of the MADDY Study is to better understand how symptoms of negative affect and impaired cognition relate to differences in metabolism, the gut microbiome, genetics and epigenetics, neurotransmitter and hormone levels, and inflammation. Toward this goal, we will compare behavioral data from a range of standardized measures completed by children, parents, and teachers/other adults to biological data collected from samples of blood, saliva, urine, stool, and hair. 

This is an international, multi-site study being conducted at OHSU, The Ohio State University, and University of Lethbridge in Alberta, Canada. 

International MADDY Team
The MADDY Study team from Canada and Oregon gather in Columbus with the Ohio State team

The MADDY study primary data collection is completed and results are pending. 

Currently, our lab is assessing cortisol, neurotransmitter, and cytokine levels in biological samples (e.g. plasma, urine, hair, saliva) from the MADDY study participants to examine the mechanism of response to the 36-ingredient broad spectrum multinutrient. We have produced two papers seen in our publications tab, with our primary outcomes paper in development.