Chemical Biology and Physiology Conference 2019

Chemical Biology & Physiology Conference 2019

The Chemical Biology and Physiology Conference series is a biennial international conference focused on the growing intersection of Chemical Biology and Physiology.  The interaction of Chemical Biology and Physiology provides innovative opportunities for drug target discovery and novel therapeutic concepts.  This conference brings together leading scientists from around the world to promote the inspiration and collaboration to stimulate cutting edge research in this exciting research nexus.  This year’s topics of focus include Chemical Physiology, Imaging, Glyco Chemical Biology, Nucleotide Chemical Biology, Optical Tools and Protein Magic.

Download the Program booklet.

Location                                                                                Dates                                                       

Knight Cancer Research Building                          December 12-15, 2019             
Oregon Health & Science University                                                                          
2720 S.W. Moody Ave.                                                                                                
Portland, OR 97201

Keynote speakers

Ben Cravatt headshot

Benjamin Cravatt, Ph.D.
Gilula Chair of Chemical Biology 
Professor, Department of Chemistry, Scripps Research

Eric Gouaux headshot in front of bookcase

Eric Gouaux, PhD
Jennifer and Bernard Lacroute Term Chair in Neuroscience Research
Oregon Health & Science University

Laura L. Kiessling headshot

Laura L. Kiessling, Ph.D.
Novartis Professor of Chemistry
Massachusetts Institute of Technology

Tom Muir, PhD

Tom Muir, Ph.D.
Van Zandt Williams, Jr. Class of '65 Professor of Chemistry
Chair of Chemistry, Princeton University

Invited speakers

David Chenoweth, University of Pennsylvania, USA
Virginia Cornish, Columbia University, USA
Matthew Disney, The Scripps Research Institute, Florida, USA
Graham Ellis-Davies, Mount Sinai, USA
Michael Fischbach, Stanford University, USA
James Frank, Oregon Health & Science University, USA
Jennifer Heemstra, Emory University, USA
Paul Heppenstall, European Molecular Biology Laboratory, Italy
Linda Hsieh-Wilson, California Institute of Technology, USA
Martin Kelly, Oregon Health & Science University, USA
Kazuya Kikuchi, Osaka University, Japan
Jennifer Kohler, UT Southwestern Medical Center, USA
Maja Köhn, University of Freiburg, Germany
Luke Lavis, HHMI Janelia, USA
Andreas Marx, University of Konstanz, Germany
Raymond Moellering, University of Chicago, USA
Hermen Overkleeft, Leiden University, The Netherlands
Amy Palmer, University of Colorado, Boulder, USA
Matt Pratt, University of Southern California, USA
Matthew Simon, Yale University, USA
Peter Wang, University of California, San Diego, USA

Science Steering Committee

Carsten Schultz, PhD   
Tom Scanlan, PhD
Mike Cohen, PhD
Francis Valiyaveetil, PhD
Xiangshu Xiao, PhD

Organizers

Amy Johnson
Alanna Lapp

Contact the organizers: chembiophysinquiries@ohsu.edu

Download the program

THURSDAY – DECEMBER 12, 2019

11:00 – 13:00 - Registration and Welcome

13:00 – 13:10 - Opening Remarks

SESSION 1: CHEMICAL PHYSIOLOGY 
                     Chair: Skylar Ferrara 

13:10 – 13:45 - Paul Heppenstall, Scuola Internazionale Superiore di Studi Avanzati, Italy 
                            
Chemical biology under the skin

13:45 – 14:20 - Martin Kelly, Oregon Health & Science University, USA 
                            
Elucidating Hypothalamic Circuits Controlling Homeostatic Functions Using Optogenetics

14:20 – 14:35 - Short Talk: Anupam Patgiri, Harvard Medical School, USA 
                            
An Engineered Enzyme to Alleviate Reductive Stress in Mitochondrial Disease

14:35 – 15:05 - Break

15:05 – 15:40 - Raymond Moellering, University of Chicago, USA 
                            
Chemical Proteomic Platforms to Expose and Exploit Novel Metabolic Signals in Disease

15:40 – 16:15 - Michael Fischbach, Stanford University, USA 
                             
Small molecules from the human microbiota

16:15 – 16:30 - Short Talk: Erin Carlson, University of Minnesota, Twin Cities, USA 
                            
Chronic exposure to complex metal oxide nanoparticles elicits rapid bacterial resistance

16:30 – 17:10 - Flash Talks: Poster presenters (1.5 min/1 slide)

17:10 – 17:20 - Break

17:20 – 18:20 - KEYNOTE SPEAKER – Benjamin Cravatt, The Scripps Research Institute, USA 
                            Activity-based proteomics – protein and ligand discovery on a global scale
                             
Chair: Skylar Ferrara                            

18:20 – 20:00 - Conference Dinner and Reception

FRIDAY – DECEMBER 13

SESSION 2: IMAGING 
                     Chair: Jon Savage

09:00 – 09:35 - Amy Palmer, University of Colorado, Boulder, USA 
                            
Riboglow: a new platform for tracking RNA molecules in live mammalian cells

09:35 – 10:10 - Kazuya Kikuchi, Osaka University, Japan 
                            
New Biological Findings which were Revealed by Designed Fluorescent Probes

10:10 – 10:25 - Short Talk: Alison Tebo, Sorbonne Université, France 
                            
Split fluorescent reporters with rapid and reversible complementation

10:25 – 10:55 - Break

10:55 – 11:30 - Luke Lavis, HHMI Janelia, USA 
                            
From single-molecule imaging to the brain: A circuitous route to new neural activity indicators

11:30 – 12:05 - Peter Wang, University of California, San Diego, USA 
                           
Live Cell Imaging and Cellular Reprogramming in Immuno-engineering

12:05 – 12:20 - Short Talk: Rahul Singh Kathayat, The University of Chicago, USA 
                            
Chemical approaches to probe the regulation of S-palmitoylation

12:20 – 13:00 - Flash Talks: Poster presenters (1.5 min/1 slide)

13:00 – 14:00 - Lunch, Meet the Speakers

14:00 – 15:30 - Poster Session I (odd poster numbers)

SESSION 3: OPTICAL TOOLS
                     Chair: Carsten Schultz

15:30 – 16:05 - David M. Chenoweth, University of Pennsylvania, USA 
                            
Design and synthesis of new chemical tools for probing, manipulating, and imaging biological systems

16:05 – 16:40 - Graham Ellis-Davies, Mount Sinai, USA 
                            
Physiology with caged compounds

16:40 – 17:15 - James Frank, Oregon Health & Science University, USA 
                           
Optical tools for manipulating classical and orphan cannabinoid receptors

17:15 – 18:15 - KEYNOTE SPEAKER – Eric Gouaux, Oregon Health & Science University, USA
                            Architectures and mechanisms of signaling at the chemical synapses of the brain
                            Chair: Julia Huey
                         

SATURDAY – DECEMBER 14

SESSION 4: NUCLEOTIDE CHEMICAL BIOLOGY
                     Chair: Kelsie Rodriguez

09:00 – 09:35 - Matthew Disney, The Scripps Research Institute, Florida, USA 
                            
Translating RNA sequence into lead small molecule medicines

09:35 – 10:10 - Matthew Simon, Yale University, USA 
                            
Chemical tools to study the dynamics of the transcriptome

10:10 – 10:25 - Short Talk: Linglan Fang, University of Washington, USA 
                            
A chemoproteomic platform for profiling the cellular interactome of protein kinases

10:25 – 10:55 - Break

10:55 – 11:30 - Andreas Marx, University of Konstanz, Germany 
                            
Friends or Foes? News on old Nucleotides

11:30 – 12:05 - Jennifer Heemstra, Emory University, USA 
                           
A chemical biology toolbox for RNA post-transcriptional modification and capture

12:05 – 12:20 - Short Talk: Elisar Barbar, Oregon State University, USA 
                            
The LC8-RavP ensemble structure evinces a role for LC8 in regulating Lyssavirus polymerase functionality

12:20 – 13:00 - Flash Talks: Poster presenters (1.5 min/1 slide)

13:00 – 14:00 - Lunch, Meet the Editors 

14:00 – 15:30 - Poster Session II (even poster numbers)

SESSION 5: GLYCO CHEMICAL BIOLOGY
                     Chair: Veronica Cochrane

15:30 – 16:05 - Jennifer Kohler, UT Southwestern Medical Center, USA 
                            
Intestinal fucose, in sickness and in health

16:05 – 16:40 - Linda Hsieh-Wilson, California Institute of Technology, USA 
                            
Neuroplasticity and the Sweeter Side of Cell Signaling

16:40 – 16:55 - Short Talk: Markus Lakemeyer, Stanford University, USA 
                            
Functional profiling of proteases that modulate host-bacterial interactions in the gut

16:55 – 17:55 - KEYNOTE SPEAKER - Laura Kiessling, Massachusetts Institute of Technology, USA
                            Glycans as Microbial IDs
                            Chair: Veronica Cochrane

 

SUNDAY – DECEMBER 15

SESSION 6: PROTEIN MAGIC
Chair: Erika Riederer

08:30 – 09:05 - Maja Köhn, University of Freiburg, Germany 
                            
Specific modulators of protein phosphatase-1 and their application in heart failure

09:05 – 09:40 - Matthew Pratt, University of Southern California, USA 
                            
O-GlcNAc as a multifaceted inhibitor of amyloid aggregation

09:40 – 09:55 - Short Talk: Leah Frye, Schrödinger 
                            
Computationally-Driven, Structure-Based Drug Discovery

09:55 – 10:25 - Break

10:25 – 11:00 - Hermen Overkleeft, Leiden University, The Netherlands 
                            
Activity-based glycosidase profiling in biomedicine and biotechnology

11:00 – 11:35 - Virginia Cornish, Columbia University, USA 
                            
Expanding the Synthetic Capabilities of Yeast

11:35 – 12:35 - KEYNOTE SPEAKER –Tom Muir, Princeton University, USA 
                            Painting Chromatin with Synthetic Protein Chemistry
                            Chair: Francis Valiyaveetil

12:35 – 12:45 - Closing Remarks

12:45 - Lunch

Registration and abstract submission is now open

Register and Submit Abstract Here

Registration fees include admissions, conference materials, lunch and coffee breaks.

There is an additional $20 fee for the conference dinner on December 12.

General Early-Bird 350 USD
Regular 450 USD
Industry 600 USD
OHSU 175 USD
Invited Speaker 0 USD

The conference venue is just south of downtown Portland, Oregon, and easily accessible by the Portland Streetcar and MAX light rail.  This makes most downtown Portland hotels a convenient choice for conference accommodations. 

The two conference-recommended hotels are:

Hyatt House Portland Downtown
2080 SW River Drive
Portland, OR 97201
503-241-2775
Map

·   Nightly room rate: $134 + applicable taxes and fees

·   Room discount is based on room availability, and expires November 12, 2019

·   0.3 miles from conference venue, within easy walking distance

To reserve a room: Call 1-866-974-9288 and reserve a room in the “OHSU block”, or reserve online at Hyatt House Reservations with group code G-USHO.  Once the dates are entered the group rate will populate.

Hotel Zags
515 SW Clay Street
Portland, OR 97201
503-308-1637
Map

·     Nightly room rate: $134 + applicable taxes and fees

·     Room discount is based on room availability, and expires November 19, 2019

·     1.0 miles from conference venue

·     Accessible by the Portland Streetcar A Loop and NS Line and MAX Orange Line

To reserve a room: Call the hotel directly at 877-484-1084 and ask for the “OHSU December Group Rate” or reserve online at Hotel Zags Reservations with group code 235191212OHSUD. 

Sponsors

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Knight Cancer Institute
Chemical Science
Organic & Biomolecular Chemistry
RSC Advances
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schrodinger logo
Chem bio logo
Sirius fine chemicals logo
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