Nuclear Magnetic Resonance (NMR) Core Facility

The NMR core facility has a Bruker 400 MHz Avance NEO NanoBay spectrometer, a powerful analytical tool routinely used for structural biology research. Housed in the Department of Chemical Physiology & Biochemistry, room number LBRB 670, the spectrometer is equipped with a 24 - position Sample Case automation system and a broad band iProbe.

The NMR instrument can be used for:

• Standard 1H/13C experiments (1D/2D) for monitoring reaction progress, checking purity and determining molecular structure and concentration.
• Advanced 2D NMR experiments (COSY, HSQC, HMBC, DEPT, NOESY/ROESY) for further structurale elucidation.
• Multi-nuclear NMR analysis (31P, 19F, 15N and other)
•  Designing small molecules as probes of protein and cellular function
• Providing the foundation for the development of prototype therapeutic agents.

The instrument is available for “walk-on” use once the user is trained. Wilmad Precision NMR tubes model numbers 527-PP-7 (7”) and 527-PP-8 (8”) are recommended as lower quality tubes not only result in poor spectra by introducing large spinning bands and bad line shape, but also damage the Probe.