Recent publications and preprints

Tetrazine functionalized graphene enables capture of ultra-low concentrations of biomacromolecules.
Gupta RK, Jeong H, Goehring A, Gouaux E, He M. (2026) Small 22, no. 28: e13723. doi.org/10.1002/smll.202513723.

Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors.
Kim J, Benton AJ, Lotti JS, Rouzbeh N, Hansen KB, Gouaux E. (2026) bioRxiv [Preprint]. Apr 14:2026.04.13.718261. doi: 10.64898/2026.04.13.718261.

AMPAR immunization induces progressive autoimmune encephalitis with autoreactive B cells in the brain. 
Wilke JBH, Celis G, Peng NY, Sheldon N, Spangler CJ, Srivastava DK, Goehring A, Prüss H, Westbrook G, Rodda LB, Gouaux E. (2026) bioRxiv [Preprint]. May 27. doi: 10.64898/2026.05.26.727986.

Native AMPA receptor architecture reveals SynDIG4 engagement and auxiliary subunit heterogeneity.
Fang C, Gouaux E. (2026) Sci Adv. Jun 12;12(24):eaee7973. doi: 10.1126/sciadv.aee7973.

The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia. 
Clark S, Mitra J, Elferich J, Goehring A, Ge J, Ha T, Gouaux E. (2026) Biophysical J., 125(6):1464-1474. doi: 10.1016/j.bpj.2026.02.003.

Molecular assemblies and pharmacology of cerebellar GABA_A receptors. 
Sun C, Jahncke JN, Wright KM, Gouaux E. (2026) PNAS, 123(6): e2524504123. doi: 10. 10.1073/pnas.2524504123.

Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.
Park J, Gouaux E. (2026) Protein Sci., 34(2):e70483. doi: 10.1002/pro.70483.

Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis. 
Kim J, Jalali-Yazdi F, Jones BE, Westbrook G, Gouaux E. (2026) Sci Adv., 12(3):eaeb4249. doi: 10.1126/sciadv.aeb4249.

Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography. 
Kim H, Spangler CJ, Matsui A, Elferich J, Kim J, Roseborough A, Nyman M, Lahtinen TM, Gouaux E. (2025) PNAS, 122(48):e2524034122. doi: 10.1073/pnas.2524034122.

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements. 
Abbott JA, Kim J, Liu B, Popescu GK, Gouaux E, Jalali-Yazdi F. (2025) Sci Adv., 11(39):eadx4647. doi: 10.1126/sciadv.adx4647.

The bile acid-sensitive ion channel is gated by Ca²⁺-dependent conformational changes in the transmembrane domain
Freitas MM, Gouaux E. (2025) Nature Communications, 16(6746). doi:10.1038/s41467-025-62038-9.

Gating and noelin clustering of native Ca²⁺-permeable AMPA receptors. 
Fang C, Spangler CJ, Park J, Sheldon N, Trussell LO, Gouaux E. (2025) Nature. doi:10.1038/s41586-025-09289-0.

Generation of conformation-specific monoclonal antibodies for integral membrane proteins.
Sheldon N*, Dhandapani G*, Kim J*, Spangler CJ, Fang C, Park J, Rao P, Gouaux E. (2025) Current Protocols, 5(5);e70142 (*contributed equally). doi: 10.1002/cpz1.70142.

Selected publications

Structure of the human dopamine transporter and mechanisms of inhibition
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E. (2024) Nature. 632(8025):672-677.

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Yu J*, Rao P*, Clark S, Mitra J, Ha T, Gouaux E. (2021) Nature. 594:448-453. (*contributed equally)

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
Ge J*, Elferich J*, Goehring A, Zhao J, Schuck P, Gouaux E. (2018) eLife. 7:e38770. (*contributed equally)

Glycine receptor mechanism elucidated by electron cryo-microscopy
Du J*, Lü W*, Wu S, Cheng Y, Gouaux E. (2015) Nature. 526:224-229. (*contributed equally)

Neurotransmitter and psychostimulant recognition by the dopamine transporter
Wang KH*, Penmatsa A*, Gouaux E. (2015) Nature. 521:322-327. (*contributed equally)

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism
Chen L, Dürr KL, Gouaux E. (2014) Science. 345:1021-1026.

NMDA receptor structures reveal subunit arrangement and pore architecture
Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. (2014) Nature. 511:191-197.

X-ray structure of dopamine transporter elucidates antidepressant mechanism
Penmatsa A*, Wang KH*, Gouaux E. (2013) Nature. 503:85-90. (*contributed equally)

Molecular mechanism of ATP binding and ion channel activation in P2X receptors
Hattori M and Gouaux E. (2012) Nature. 485:207-212.

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Krishnamurthy H and Gouaux E. (2012) Nature. 481:469-474.

Principles of activation and permeation in an anion-selective Cys-loop receptor
Hibbs RE and Gouaux E. (2011) Nature. 474:54-60.