Members

Sarah Clark

Sarah Clark
Postdoctoral Fellow
clarsara@ohsu.edu

Sarah received a B.S. degree in Biochemistry and Molecular Biology from the University of California, Davis in 2011. She then completed an M.S. degree in Systems Engineering at George Washington University while working at a startup pharmaceutical company in Maryland that focused on the development of therapeutic antibodies. Sarah joined the lab of Dr. Elisar Barbar at Oregon State University in 2013. In her doctoral research, she explored the structure and dynamics of intrinsically disordered proteins using NMR spectroscopy. After receiving her Ph.D., Sarah joined the Gouaux lab in March 2018 to study the structure and function of transmembrane proteins.

Chengli Fang head shot image

Chengli Fang
Postdoctoral Fellow
fangch@ohsu.edu

Chengli received B.S. degree in Biological Engineering from Hunan University of Science and Technology, in 2016. Then, he joined Dr. Yu Zhang’s lab at Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, to study the mechanisms for RNA polymerase (RNAP) transcription, transcription initiation, and activation. After receiving his Ph.D., Chengli joined the Gouaux lab in June 2022 to study the structural and functional basis of neurotransmitter receptors.

Makayla Freitas

Makayla Freitas
Graduate Student
freitama@ohsu.edu

Makayla received B.S. degrees in Molecular & Cellular Biology and Psychology from the University of Arizona in 2019. At UA, she worked with Professor Rebecca Page to study the highly dynamic, interacting proteins that comprise signal transduction networks using X-ray crystallography and nuclear magnetic resonance (NMR). Makayla joined the Gouaux lab in the summer of 2020 to study the structure and function of transmembrane proteins using cryo-EM.

April Goehring

April Goehring
Senior Research Associate
goehring@ohsu.edu

April Goehring earned a B.A. in Biochemistry from the University of Colorado-Boulder in 1993, and as an undergraduate participated in projects to characterize the regulation of MAP kinase kinase. In her graduate research, April’s work focused on the identification and characterization of proteins in yeast involved in polarized cell growth. She was granted a Ph.D. in Biochemistry in 2002 from the University of Oregon. Her postdoctoral training was carried out at the Vollum Institute where she studied anchored PKA signal transduction. Since joining the Gouaux lab in 2008, she has spent her time studying the molecular mechanisms of neurotransmitter transporters and receptors.

Hanbin Jeong

Hanbin Jeong
Postdoctoral Fellow
jeongh@ohsu.edu

Hanbin received his B.S. degree in Life Sciences from Ulsan National Institute of Science and Technology (UNIST), South Korea in 2014. He then joined the lab of Dr. Changwook Lee at UNIST. In his doctoral research, Hanbin mainly focused on the structural studies of membrane contact sites (MCSs) protein complex using X-ray crystallography. After receiving his Ph.D. degree in 2019, he continued his work in the Lee Lab. Hanbin joined the Gouaux Lab in 2021 to study the structure and function of transmembrane channel proteins using cryo-electron microscopy.

Junhoe Kim

Junhoe Kim
Postdoctoral Fellow
kimjunh@ohsu.edu

Junhoe received his B.S. degree in Life Sciences in 2011 at Korea University, Republic of Korea and started a Ph.D. course in Molecular Biology in the lab of Professor Hyun Kyu Song at the same university. His thesis focused on the studies of structure and function of human autophagy-related (ATG) proteins underlying autophagosome maturation mechanism. After earning his Ph.D. degree, Junhoe joined Eric Gouaux’s lab in the summer of 2019 to study the structure and function of neurotransmitter receptors.

Aya Matsui

Aya Matsui
Senior Research Associate
matsuia@ohsu.edu

Aya received a B.S. degree in Neurobiology from the University of Washington in 2007. She joined the lab of Dr. John Williams at OHSU for her Ph.D. research, which investigated how activation of the mu-opioid receptor disinhibits the dopamine neuron and its modulation following chronic opioid treatment. Aya completed her postdoctoral training in the lab of Dr. Veronica Alvarez at the National Institute of Alcohol Abuse and Alcoholism (NIH), where she studied neuronal modulation following drugs of abuse, such as cocaine and alcohol. She joined the Gouaux lab in 2020 to study the structure and function of synaptic receptors.

Jumi Park

Jumi Park
Postdoctoral Fellow
parkjum@ohsu.edu

Jumi received a B.S degree in Life Sciences from Ulsan National Institute of Science and Technology, South Korea in 2016. She then joined Prof. Changwook Lee’s lab at the same university, focusing on the molecular mechanisms of membrane contact sites between organelles and DNA/RNA processing proteins. After earning her Ph.D., Jumi joined the Gouaux lab in April 2021 to investigate the structure and function of neurotransmitter receptors.

Prashant Rao

Prashant Rao
Graduate Student
raop@ohsu.edu

Prashant received his B.S. degree in Bioengineering from the University of Maryland in 2011. He went on to join the lab of Dr. Sriram Subramaniam at the National Institutes of Health, focusing primarily on optimization of sample preparation and cryo-electron microscopy techniques. Prashant joined the Gouaux lab in the summer of 2018 to investigate the structural and functional properties of neurotransmitter receptors.

Natalie Sheldon

Natalie Sheldon
Lab Manager
sheldonn@ohsu.edu

Natalie was born and raised in Oregon and earned a B.S. in Biology from Hope College in Holland, MI. While earning her degree she worked on the transporter system xc- in Leah Chase's lab. After graduation in 2006 she joined the Gouaux lab, and her primary role has been to do support work for the entire lab. Natalie also does the purchasing for the lab and tries her hardest to maintain some organization and cleanliness around the lab.

Cathy Spangler head shot

Cathy Spangler
Post Doctoral Fellow
andecath@ohsu.edu

Cathy received B.S. degrees in Chemistry and Biology from the University of North Carolina at Chapel Hill in 2016. She went on to conduct her graduate research at the same institution in the lab of Dr. Robert McGinty, where she used single particle cryo-electron microscopy to investigate how chromatin-interacting proteins bind to and enzymatically target specific sites on the nucleosome. After earning her PhD, Cathy joined the Gouaux lab in the Spring of 2022 and is exploring the structural and functional basis of neurotransmitter receptor misregulation in glioblastoma.

Dushyant Srivastava head shot

Dushyant Srivastava
Postdoctoral Fellow
srivastd@ohsu.edu

Dushyant received his B.Sc. degree in 2011 and M.Sc. degree in 2013 in Zoology from University of Calcutta, India. He then joined the lab of Dr. Siddhartha Roy at CSIR-Indian Institute of Chemical Biology to pursue his doctoral research work in the field of chromatin biology where he pursued structural studies on histone chaperones and chromatin reader protein by X-ray crystallography. After receiving his Ph.D. in Biochemistry from University of Calcutta, India he joined Gouaux Lab in June 2022 to study the structural and functional aspects of neurotransmitter transporters. 

Chang Sun, PhD

Chang Sun
Postdoctoral Fellow
sunch@ohsu.edu

Chang received his B.S. in Pharmacy from Fudan University, China, in 2010. He then started his graduate studies in Biochemistry at the University of Illinois, under the supervision of Profs. Colin Wraight and Robert Gennis. Chang's research focused on characterizations of bioenergetic enzymes with magnetic resonance spectroscopy and time-resolved optical spectroscopy. After receiving his Ph.D. in May 2016, he remained at the University of Illinois to work on a joint project with Profs. Gennis and Emad Tajkhorshid, and Prof. John Rubinstein from SickKids, Canada. Together, they solved a new respiratory protein structure with the styrene-maleic acid copolymer. Chang joined the Gouaux Lab in November 2018 to study the molecular mechanism of ligand-gated ion-channel by cryo-electron microscopy.

Hongtao Zhu

Hongtao Zhu
Postdoctoral Fellow
zhho@ohsu.edu

Hongtao received his B.A. degree from Ocean University of China in 2009, then began his Ph.D. work in the lab of Ping Zhu at the Institute of Biophysics, Chinese Academy of Sciences, where he worked mainly on virus-like particles using CryoEM. After receiving his Ph.D. in 2014, he continued his work in the Zhu lab for a year. Hongtao joined Eric Gouaux's lab in November 2015 to study the structure and function of neurotransmitter receptors.