Members

Sarah Clark

Sarah Clark
Postdoctoral Fellow
clarsara@ohsu.edu

Sarah received a B.S. degree in Biochemistry and Molecular Biology from the University of California, Davis in 2011. She then completed an M.S. degree in Systems Engineering at George Washington University while working at a startup pharmaceutical company in Maryland that focused on the development of therapeutic antibodies. Sarah joined the lab of Dr. Elisar Barbar at Oregon State University in 2013. In her doctoral research, she explored the structure and dynamics of intrinsically disordered proteins using NMR spectroscopy. After receiving her Ph.D., Sarah joined the Gouaux lab in March 2018 to study the structure and function of transmembrane proteins.

Makayla Freitas

Makayla Freitas
Graduate Student
freitama@ohsu.edu

Makayla received B.S. degrees in Molecular & Cellular Biology and Psychology from the University of Arizona in 2019. At UA, she worked with Professor Rebecca Page to study the highly dynamic, interacting proteins that comprise signal transduction networks using X-ray crystallography and nuclear magnetic resonance (NMR). Makayla joined the Gouaux lab in the summer of 2020 to study the structure and function of transmembrane proteins using cryo-EM.

Jingpeng Ge

Jingpeng Ge
Postdoctoral Fellow
gai@ohsu.edu

Jingpeng received his B.S. degree in Chemistry and Biology from Jilin University, China in 2010. He then joined Dr. Maojun Yang's laboratory at Tsinghua University, where he studied the structure and mechanism of mammalian mechanosensitive channel Piezo1 using both cryo-EM and X-ray crystallography. After receiving his Ph.D. degree, Jingpeng joined the Gouaux lab in February 2016 to investigate the structure and function of transmembrane proteins.

April Goehring

April Goehring
Senior Research Associate
goehring@ohsu.edu

April Goehring earned a B.A. in Biochemistry from the University of Colorado-Boulder in 1993, and as an undergraduate participated in projects to characterize the regulation of MAP kinase kinase. In her graduate research, April’s work focused on the identification and characterization of proteins in yeast involved in polarized cell growth. She was granted a Ph.D. in Biochemistry in 2002 from the University of Oregon. Her postdoctoral training was carried out at the Vollum Institute where she studied anchored PKA signal transduction. Since joining the Gouaux lab in 2008, she has spent her time studying the molecular mechanisms of neurotransmitter transporters and receptors.

Prerana Gogoi

Prerana Gogoi
Postdoctoral Fellow
gogoi@ohsu.edu

Prerana received her bachelor’s degree in 2010 and master’s degree in 2012 in Biotechnology from North Eastern Hill University, India. She then joined the Indian Institute of Technology (IIT) Guwahati, India, for a Ph.D. program in Structural Biology and earned her Ph.D. in 2019. Her doctoral research work in Dr. Shankar Prasad Kanaujia’s laboratory comprised structural characterization of protein translation initiation factors in archaea using X-ray crystallography. Prerana joined the Gouaux laboratory in 2020 to study the structural mechanisms of neurotransmitter receptor functions using cryo-electron microscopy.

Hanbin Jeong

Hanbin Jeong
Postdoctoral Fellow
jeongh@ohsu.edu

Hanbin received his B.S. degree in Life Sciences from Ulsan National Institute of Science and Technology (UNIST), South Korea in 2014. He then joined the lab of Dr. Changwook Lee at UNIST. In his doctoral research, Hanbin mainly focused on the structural studies of membrane contact sites (MCSs) protein complex using X-ray crystallography. After receiving his Ph.D. degree in 2019, he continued his work in the Lee Lab. Hanbin joined the Gouaux Lab in 2021 to study the structure and function of transmembrane channel proteins using cryo-electron microscopy.

Junhoe Kim

Junhoe Kim
Postdoctoral Fellow
kimjunh@ohsu.edu

Junhoe received his B.S. degree in Life Sciences in 2011 at Korea University, Republic of Korea and started a Ph.D. course in Molecular Biology in the lab of Professor Hyun Kyu Song at the same university. His thesis focused on the studies of structure and function of human autophagy-related (ATG) proteins underlying autophagosome maturation mechanism. After earning his Ph.D. degree, Junhoe joined Eric Gouaux’s lab in the summer of 2019 to study the structure and function of neurotransmitter receptors.

Aya Matsui

Aya Matsui
Senior Research Associate
matsuia@ohsu.edu

Aya received a B.S. degree in Neurobiology from the University of Washington in 2007. She joined the lab of Dr. John Williams at OHSU for her Ph.D. research, which investigated how activation of the mu-opioid receptor disinhibits the dopamine neuron and its modulation following chronic opioid treatment. Aya completed her postdoctoral training in the lab of Dr. Veronica Alvarez at the National Institute of Alcohol Abuse and Alcoholism (NIH), where she studied neuronal modulation following drugs of abuse, such as cocaine and alcohol. She joined the Gouaux lab in 2020 to study the structure and function of synaptic receptors.

Jumi Park

Jumi Park
Postdoctoral Fellow
parkjum@ohsu.edu

Jumi received a B.S degree in Life Sciences from Ulsan National Institute of Science and Technology, South Korea in 2016. She then joined Prof. Changwook Lee’s lab at the same university, focusing on the molecular mechanisms of membrane contact sites between organelles and DNA/RNA processing proteins. After earning her Ph.D., Jumi joined the Gouaux lab in April 2021 to investigate the structure and function of neurotransmitter receptors.

Prashant Rao

Prashant Rao
Graduate Student
raop@ohsu.edu

Prashant received his B.S. degree in Bioengineering from the University of Maryland in 2011. He went on to join the lab of Dr. Sriram Subramaniam at the National Institutes of Health, focusing primarily on optimization of sample preparation and cryo-electron microscopy techniques. Prashant joined the Gouaux lab in the summer of 2018 to investigate the structural and functional properties of neurotransmitter receptors.

Natalie Sheldon

Natalie Sheldon
Lab Manager
sheldonn@ohsu.edu

Natalie was born and raised in Oregon and earned a B.S. in Biology from Hope College in Holland, MI. While earning her degree she worked on the transporter system xc- in Leah Chase's lab. After graduation in 2006 she joined the Gouaux lab, and her primary role has been to do support work for the entire lab. Natalie also does the purchasing for the lab and tries her hardest to maintain some organization and cleanliness around the lab.

Chang Sun, PhD

Chang Sun
Postdoctoral Fellow
sunch@ohsu.edu

Chang received his B.S. in Pharmacy from Fudan University, China, in 2010. He then started his graduate studies in Biochemistry at the University of Illinois, under the supervision of Profs. Colin Wraight and Robert Gennis. Chang's research focused on characterizations of bioenergetic enzymes with magnetic resonance spectroscopy and time-resolved optical spectroscopy. After receiving his Ph.D. in May 2016, he remained at the University of Illinois to work on a joint project with Profs. Gennis and Emad Tajkhorshid, and Prof. John Rubinstein from SickKids, Canada. Together, they solved a new respiratory protein structure with the styrene-maleic acid copolymer. Chang joined the Gouaux Lab in November 2018 to study the molecular mechanism of ligand-gated ion-channel by cryo-electron microscopy.

Dongxue Yang

Dongxue Yang
Postdoctoral Fellow
yando@ohsu.edu

Dongxue received her B.S. degree in Biology from the University of Science and Technology of China in 2011. She then joined the lab of Professor Ruiming Xu in the Institute of Biophysics, Chinese Academy of Sciences, to study the structure of a nucleosome-related complex. After earning her Ph.D., Dongxue joined the Gouaux lab in September of 2016 and is currently investigating the structure and function of neurotransmitter transporters.

Jie Yu

Jie Yu
Postdoctoral Fellow
jiey@ohsu.edu

Jie received a B.S. degree in Biology from Jilin University, China in 2010, then joined the lab of Dr. Maojun Yang in the Center for Structural Biology at Tsinghua University. In her graduate research, she mainly focused on the underlying mechanism for substrate specificity of amino acid ABC transporters using X-ray crystallography. After receiving her Ph.D. degree in the summer of 2015, Jie joined the Gouaux Lab in early 2016 and is currently investigating the structural and functional properties of the key proteins in the development of chronic myelogenous leukemia, combining X-ray crystallography and electron microscopy.

Hongtao Zhu

Hongtao Zhu
Postdoctoral Fellow
zhho@ohsu.edu

Hongtao received his B.A. degree from Ocean University of China in 2009, then began his Ph.D. work in the lab of Ping Zhu at the Institute of Biophysics, Chinese Academy of Sciences, where he worked mainly on virus-like particles using CryoEM. After receiving his Ph.D. in 2014, he continued his work in the Zhu lab for a year. Hongtao joined Eric Gouaux's lab in November 2015 to study the structure and function of neurotransmitter receptors.