Members

Sarah Clark

Sarah Clark
Postdoctoral Fellow
clarsara@ohsu.edu

Sarah received a B.S. degree in Biochemistry and Molecular Biology from the University of California, Davis in 2011. She then completed an M.S. degree in Systems Engineering at George Washington University while working at a startup pharmaceutical company in Maryland that focused on the development of therapeutic antibodies. Sarah joined the lab of Dr. Elisar Barbar at Oregon State University in 2013. In her doctoral research, she explored the structure and dynamics of intrinsically disordered proteins using NMR spectroscopy. After receiving her Ph.D., Sarah joined the Gouaux lab in March 2018 to study the structure and function of transmembrane proteins.

Jonathan Coleman

Jonathan Coleman
Postdoctoral Fellow
colemajo@ohsu.edu

Jonathan studied Biochemistry at the University of British Columbia (UBC), Canada earning a B.S. degree in 2007. As an undergraduate student, he explored the mechanism of protein secretion through the Sec translocon. Jonathan earned his Ph.D. in 2013 at UBC as a student in the lab of Dr. Robert Molday investigating the membrane biology of photoreceptors. His thesis examined an aminophospholipid transporting P4-ATPase and provided valuable insights into the transport mechanism and function in neuronal biology. Jonathan joined Eric Gouaux’s lab in early 2013 and is interested in the structure and pharmacology of neurotransmitter transporters.

Johannes Elferich

Johannes Elferich
Postdoctoral Fellow
elferich@ohsu.edu

Johannes received a B.A. degree in Molecular Biotechnology from the Technical University Munich, Germany in 2010. He then joined the lab of Dr. Ujwal Shinde at OHSU. In his doctoral work he investigated the effect of pH on activation of proprotein convertases using computational and biophysical techniques. After receiving his Ph.D. in 2015 he joined the Gouaux lab to study the structure and function of transmembrane proteins.

Jingpeng Ge

Jingpeng Ge
Postdoctoral Fellow
gai@ohsu.edu

Jingpeng received his B.S. degree in Chemistry and Biology from Jilin University, China in 2010. He then joined Dr. Maojun Yang's laboratory at Tsinghua University, where he studied the structure and mechanism of mammalian mechanosensitive channel Piezo1 using both cryo-EM and X-ray crystallography. After receiving his Ph.D. degree, Jingpeng joined the Gouaux lab in February 2016 to investigate the structure and function of transmembrane proteins.

April Goehring

April Goehring
Senior Research Associate
goehring@ohsu.edu

April Goehring earned a B.A. in Biochemistry from the University of Colorado-Boulder in 1993, and as an undergraduate participated in projects to characterize the regulation of MAP kinase kinase. In her graduate research, April’s work focused on the identification and characterization of proteins in yeast involved in polarized cell growth. She was granted a Ph.D. in Biochemistry in 2002 from the University of Oregon. Her postdoctoral training was carried out at the Vollum Institute where she studied anchored PKA signal transduction. Since joining the Gouaux lab in 2008, she has spent her time studying the molecular mechanisms of neurotransmitter transporters and receptors.

Farzad Jalali-Yazdi

Farzad Jalali-Yazdi
Postdoctoral Fellow
jalaliya@ohsu.edu

Farzad received his B.S. degrees in Chemical Engineering and Biology from MIT. At MIT, he worked with Professors Langer and Cima to develop implantable devices to monitor hCG concentrations in cancer patients. After MIT, Farzad worked for two years as a scientist and engineer at BioScale, Inc., a biotechnology startup company in Cambridge, developing accurate and sensitive assays on a new MEMS platform. He received his Ph.D. in 2015 from USC, working to develop and characterize peptide ligands using mRNA display. His research in Professor Roberts' laboratory focused on developing a peptide-targeted peptide ligand capable of stopping HCV virus particle production in human liver cells, as well as using mRNA display and NextGen sequencing to characterize the binding kinetics for thousands of ligands simultaneously. He joined the Gouaux lab in fall of 2016 to study the structural mechanisms of neurotransmitter receptor functions by cryo-electron microscopy.

Junhoe Kim

Junhoe Kim
Postdoctoral Fellow
kimjunh@ohsu.edu

Junhoe received his B.S. degree in Life Sciences in 2011 at Korea University, Republic of Korea and started a Ph.D. course in Molecular Biology in the lab of Professor Hyun Kyu Song at the same university. His thesis focused on the studies of structure and function of human autophagy-related (ATG) proteins underlying autophagosome maturation mechanism. After earning his Ph.D. degree, Junhoe joined Eric Gouaux’s lab in the summer of 2019 to study the structure and function of neurotransmitter receptors.

Vikas Navratna

Vikas Navratna
Postdoctoral Fellow
navratna@ohsu.edu

Vikas graduated from Osmania University, India, with a bachelor's degree in Biotechnology in 2005 and master's degree in Biochemistry in 2007. He then joined the Molecular Biophysics Unit (MBU) of the Indian Institute of Science (IISc), Bangalore, India, for a Ph.D. program in Structural Biology and Biochemistry. His research work in Professor B. Gopal's laboratory comprised structural and biochemical characterization of proteins involved in peptidoglycan synthesis, antibiotic resistance and essential amino acid metabolism in gram-positive bacteria. He received his Ph.D. in 2014 and continued working at IISc as a Research Associate. He studied RNA degradosome machinery of gram-positive bacteria briefly, before joining the Gouaux laboratory in February of 2015 to research the structural and mechanistic aspects of neurotransmitter transporters.

Prashant Rao

Prashant Rao
Graduate Student
raop@ohsu.edu

Prashant received his B.S. degree in Bioengineering from the University of Maryland in 2011. He went on to join the lab of Dr. Sriram Subramaniam at the National Institutes of Health, focusing primarily on optimization of sample preparation and cryo-electron microscopy techniques. Prashant joined the Gouaux lab in the summer of 2018 to investigate the structural and functional properties of neurotransmitter receptors.

Natalie Sheldon

Natalie Sheldon
Lab Manager
sheldonn@ohsu.edu

Natalie was born and raised in Oregon and earned a B.S. in Biology from Hope College in Holland, MI. While earning her degree she worked on the transporter system xc- in Leah Chase's lab. After graduation in 2006 she joined the Gouaux lab, and her primary role has been to do support work for the entire lab. Natalie also does the purchasing for the lab and tries her hardest to maintain some organization and cleanliness around the lab.

Chang Sun, PhD

Chang Sun
Postdoctoral Fellow
sunch@ohsu.edu

Chang received his B.S. in Pharmacy from Fudan University, China, in 2010. He then started his graduate studies in Biochemistry at the University of Illinois, under the supervision of Profs. Colin Wraight and Robert Gennis. Chang's research focused on characterizations of bioenergetic enzymes with magnetic resonance spectroscopy and time-resolved optical spectroscopy. After receiving his Ph.D. in May 2016, he remained at the University of Illinois to work on a joint project with Profs. Gennis and Emad Tajkhorshid, and Prof. John Rubinstein from SickKids, Canada. Together, they solved a new respiratory protein structure with the styrene-maleic acid copolymer. Chang joined the Gouaux Lab in November 2018 to study the molecular mechanism of ligand-gated ion-channel by cryo-electron microscopy.

Dongxue Yang

Dongxue Yang
Postdoctoral Fellow
yando@ohsu.edu

Dongxue received her B.S. degree in Biology from the University of Science and Technology of China in 2011. She then joined the lab of Professor Ruiming Xu in the Institute of Biophysics, Chinese Academy of Sciences, to study the structure of a nucleosome-related complex. After earning her Ph.D., Dongxue joined the Gouaux lab in September of 2016 and is currently investigating the structure and function of neurotransmitter transporters.

Nate Yoder

Nate Yoder
Graduate Student
yodern@ohsu.edu

Nate received bachelor's degrees in Physiology and Chemistry from Michigan State University in 2011. While working as a research technician in the laboratory of Dr. Jason Shepherd, Nate studied the structure of Arc/Arg3.1, a synaptic protein involved in experience-dependent AMPA receptor trafficking. Now a graduate student at OHSU, Nate is interested in the molecular mechanisms that govern ion channel function and synaptic regulation at central nervous system synapses. He joined the Gouaux Lab in 2015 to study the structure and function of acid sensing ion channels using a combination of x-ray crystallography, cryo-electron microscopy, and electrophysiology approaches.

Jie Yu

Jie Yu
Postdoctoral Fellow
jiey@ohsu.edu

Jie received a B.S. degree in Biology from Jilin University, China in 2010, then joined the lab of Dr. Maojun Yang in the Center for Structural Biology at Tsinghua University. In her graduate research, she mainly focused on the underlying mechanism for substrate specificity of amino acid ABC transporters using X-ray crystallography. After receiving her Ph.D. degree in the summer of 2015, Jie joined the Gouaux Lab in early 2016 and is currently investigating the structural and functional properties of the key proteins in the development of chronic myelogenous leukemia, combining X-ray crystallography and electron microscopy.

Yan Zhao

Yan Zhao
Postdoctoral Fellow
zhaya@ohsu.edu

Yan received his B.S. degree in Biophysics in 2010 and then was admitted to the University of Science and Technology of China for doctoral study. In July 2011, he joined Professor Cai Zhang's lab in the Institute of Biophysics, Chinese Academy of Sciences, to study the structure and function of transporters that belong to the major facilitator superfamily. After earning his Ph.D. degree, Yan joined the Gouaux lab in the summer of 2015 and is currently investigating the structure and function of neurotransmitter receptors.

Hongtao Zhu

Hongtao Zhu
Postdoctoral Fellow
zhho@ohsu.edu

Hongtao received his B.A. degree from Ocean University of China in 2009, then began his Ph.D. work in the lab of Ping Zhu at the Institute of Biophysics, Chinese Academy of Sciences, where he worked mainly on virus-like particles using CryoEM. After receiving his Ph.D. in 2014, he continued his work in the Zhu lab for a year. Hongtao joined Eric Gouaux's lab in November 2015 to study the structure and function of neurotransmitter receptors.

NIH K99/R00 Pathway to Independence

Steven Mansoor

Steven Mansoor
Assistant Professor, OHSU Knight Cardiovascular Institute
mansoors@ohsu.edu

Steve graduated from Reed College in 1997 with a B.A. in Biochemistry and Molecular Biology before matriculating into the M.D./Ph.D. program at Oregon Health & Science University in 1999. For his Ph.D. dissertation, he developed fluorescence techniques to study membrane protein structure and conformational changes, with a focus on understanding the dynamics of G-protein coupled receptor activation. Currently, Steve is an assistant professor in the Knight Cardiovascular Institute at OHSU and has been awarded an NIH K99 Pathway to Independence Award to study the structure/function of purinergic receptors under the mentorship of Eric Gouaux.

Alanna McCarthy

Alanna McCarthy
Research Assistant II
mccartal@ohsu.edu

Alanna earned her B.S. degree in Cell and Molecular Biology with a Chemistry minor from Seattle University in 2017. As an undergraduate, she investigated instances of cardiac myopathy in mice with non-alcoholic fatty liver disease (NAFLD) and characterized homing endonuclease structure and activity. Alanna currently works as an assistant to Dr. Steve Mansoor studying the structure/function of purinergic receptors.