Yiyi Chen, PhD

yiyi chenTitle:

Associate Professor of Biostatistics


Radiation Medicine,OHSU-PSU School of Public Health


Design and Analysis of Clinical Trials; Bayesian Statistics; Prognostic Modeling




BA in Economics, Zhejiang University, P.R.China

Graduate Degree:

MA in Economics, Research Institute of World Economy, Fudan University, P.R. China
MA in Economics, University of Iowa
MS in Biostatistics, University of Iowa
PhD in Biostatistics, University of Iowa

Interest and Accomplishments:

As a Biostatistician, I am enthusiastic to contribute broadly and deeply to medical science and public health through collaborative research. My research in statistical methodology development is focusing on solving challenges raised by collaborative efforts.

My current research interests include Adaptive Design for Clinical Trials, Statistical Methods for Personalized Medicine, Prognostic Modeling, Big Data Analytics, Decision Theory, Analysis for Diagnostic Medicine, and Measurements of Agreement.


Chen Y, Chen Z, Motomi M (2016). A New Statistical Decision Rule for Single-arm Phase II Oncology Trials. Statistical Methods in Medical Research. 25(1): 118-132. http://smm.sagepub.com/cgi/reprint/25/1/118.pdf?ijkey=yCEgUMAN72fx8YY&keytype=finite

Tudorica A, Oh KY, Chui S Y-C, Roy N, Troxell ML, Naike A, Kemmer KA, Chen Y, Holtorf ML, Afzal A, Springer CS, Li X, Huang W. (2016). Early Prediction and Evaluation of Breast Cancer Response to Neoadjuvant Chemotherapy Using Quantitative DCE-MRI. Translational Oncology. Pp. 8-17 DOI information: 10.1016/j.tranon.2015.11.016 chen

Atkins KM, Chen Y, Elliott DA, Doshi TS, Ognjenovic S; Vachhani AS; Kishore M, Primack SL, Fuss M, Deffebach ME, Kubicky CD, Tanyi J (2014). The Impact of Anatomic Tumor Location on Inter-fraction Tumor Motion during Lung Stereotactic Body Radiation Therapy (SBRT). Journal of Radiosurgery and SBRT. 3(3): 203-213.

Holtan SG, Chen Y, Kaimal R, Creedon DJ, Enninga E, Nevala WK, Markovic SN (2015). Growth modeling of the maternal cytokine milieu throughout normal pregnancy:  Macrophage-derived chemokine decreases as inflammation/counter-regulation increases. Journal of Immunology Research. Article ID 952571, http://dx.doi.org/10.1155/2015/952571.

King LA, Wilhelm J, Chen Y, Bloem R, Nutt J, Chen Z, Serdar A, Horak FB (2015). Does Group, Effects of Group, Individual, and Home Exercise in Persons With Parkinson Disease: A Randomized Clinical Trial. (The winner of the JNPT Golden Synapse Award for best article of 2015). Journal of Neurology Physical Therapy. 39(4): 204 – 212. http://www.ncbi.nlm.nih.gov/pubmed/26308937

Scott EC, Chen Y, Chen AI, Smith S, Barkay I, Dibb W, Dibb J, Stentz A, Frires R, Maziarz RT . Chromosome 1 Abnormalities Predict Shortened Progression Free and Overall Survival in Patients with High Risk Multiple Myeloma Undergoing Autologous Hematopoietic Cell Transplantation, a Retrospective Analysis (2015). Blood and Lymph. http://dx.doi.org/10.4172/2165-7831.1000131

Chen Y, Chen Z, Halsey M (2014). A Bayesian Up-and-down Design for Clinical Trials with Multiple Adverse Events in Opposite Directions. JSM Proceedings.

Atkins KM, Chen Y, Elliott DA, Doshi TS, Ognjenovic S; Vachhani AS; Kishore M, Primack SL, Fuss M, Deffebach ME, Kubicky CD, Tanyi J (2014). The Impact of Anatomic Tumor Location on Inter-fraction Tumor Motion during Lung Stereotactic Body Radiation Therapy (SBRT). Journal of Radiosurgery and SBRT. 3(3): 203-213.

Simpson EL, Chalmers J, Hanifin JM, McLean I, Chen Z, Chen Y, Brown SJ, Thomas KS,  Cork MJ, Williams HC (2014). Emollient enhancement of skin barrier from birth offers effective atopic dermatitis prevention.  Journal of Allergy and Clinical Immunology. 134(4):818-23. (Editor’s Choice).

Cowan N, Chen Y, Downs T, Bochner B, Apolo A, Porter MP, Rochelle JL, Amling C, Koppie T (2014). Neoadjuvant Chemotherapy Use in Bladder Cancer: A Survey of Current Practice and Opinions. Advances in Urology. doi:10.1155/2014/746298.

Schlansky B, Chen Y, Scott DL, Austin D, Naugler WE (2014). Waiting Time Predicts Survival after Liver Transplantation for Hepatocellular Carcinoma: a Cohort Study in the UNOS Registry. Liver Transplantation. 20(9):1045-56. doi: 10.1002/lt.23917.

Huang W, Li X, Chen Y, Li X, Chang M-C, Oborski M, Malyarenko D, Muzi M, Jajamovich GH, Fedorov A, Tudorica A, Gupta SN, Laymon CM, Marro KI, Dyvorne HA, Miller JV, Barboriak DP, Chenevert TL, Yankeelov TE, Mountz JM, Kinahan PE, Kikinis R, Taouli B, Fennessy F, Kalpathy-Cramer J (2014). Variations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Evaluation of Breast Cancer Therapy Response: A Multicenter Data Analysis Challenge. Translational Oncology. 7(1):153-66.

VanDlac AA, Cowan NG, Chen Y, Anderson RE, Conlin MJ, La Rochelle JC, Amling CL, Koppie TM (2014). Timing, Incidence, and Risk Factors of Venous Thromboembolism in Patients Undergoing Radical Cystectomy for Malignancy: A Case for Extended Duration Pharmacologic Prophylaxis. The Journal of Urology.191(4):943-7. doi: 10.1016/j.juro.2013.10.096.  

Tanyi JA, Doss EJ, Kato CM, Monaco DL, Meng LZ, Chen Y, Kubicky CD, Marquez CM, Fuss M (2012). Dynamic Conformal Arc Cranial Stereotactic Radiosurgery: Implications of Multileaf Collimator Margin on Dose-volume Metrics. The British Journal of Radiology. The British Journal of Radiology. 85(1019):e1058-66.  

Spurgeon SE, Pindyck T, Okada C, Chen Y, Chen Z, Mater E, Abbi K, & Epner EM (2011). Cladribine Plus Rituximab is an Effective Therapy for Newly Diagnosed Mantle Cell Lymphoma. Leukemia & Lymphoma 52(8):1488-94. 

Huang W, Tudorica LA, Li X, Thakur SB, Chen Y, Morris EA, Tagge IJ, Korenblit M, Rooney WD, Koutcher JA, Springer CS (2011). Discrimination of Benign and Malignant Breast Lesions by using Shutter-Speed Dynamic-Contrast-Enhanced MR Imaging. Radiology, 261: 394-403. (Listed as one of the ‘Top 10 Most Read Recent Articles’ in Radiology for the last 3 months).

Tanyi JA, Kato C, Chen Y, Chen Z, and Fuss M (2011). Impact of the High-definition Multileaf Collimator (HD-MLC) on Linear-accelerator-based Intracranial Stereotactic Radiosurgery (SRS), British Journal of Radiology, 84(1003):629-38. Mori M, Chen Y, Alumkal J (2009). Estimation of Safe and Effective Dose in Phase I Clinical Trials in Oncology. JSM proceedings.

Chen Y and Smith BJ (2009). Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. Statistics in Medicine, 28:3347-3362.

Tanyi JA, Summers PA, McCracken CL, Chen Y, Ku L-C and Fuss M (2009). Implications of a High-Definition Multi Leaf Collimator (HD-MLC) on Treatment Planning Techniques for Stereotactic Body Radiation Therapy (SBRT): a Planning Study. Radiation Oncology, 10(4):22.

Polgreen PM, Chen Y, Beekmann S, Srinivasan A, Neill MA, Gay T and Cavanaugh JE (2008).  Elements of Influenza Vaccination Programs that Predict Higher Vaccination Rates: Results of an Emerging Infections Network Survey.  Clinical Infectious Diseases, 46(1):14-19.

Herwaldt LA, Appelgate D, Kuntz J, Chen Y and Pottinger J (2007). Infection Control Resources in Iowa. American Journal of Infection Control, 35(10), 662-665.

Polgreen P, Chen Y, Cavanaugh J, Ward M, Coffman S, Hornick D, Diekema DJ, Herwaldt LA(2007). An Outbreak of Severe Clostridium Difficile-Associated Disease Possibly Related to Inappropriate Antimicrobial Therapy for Community-Acquired Pneumonia. Infection Control and Hospital Epidemiology, 28(2), 212-214.

Additional Links :