Cell and Developmental Biology
Program in Molecular and Cellular Biosciences
Sara A. Courtneidge was born in the UK, and received her B.Sc. from the University of Leeds and her Ph.D. from the National Institute for Medical Research, London. Following postdoctoral study at the University of California, San Francisco, and an independent position at the National Institute for Medical Research, she joined the European Molecular Biology Laboratory in Heidelberg, Germany in 1985, where she rose to the position of senior scientist. Changing course in 1994, Dr. Courtneidge joined SUGEN Inc., where as chief scientist she guided novel kinase discovery and validation efforts in oncology. From 2001-2005 she was distinguished scientific investigator at the Van Andel Research Institute in Grand Rapids, Michigan, and from 2005-2014 she served as professor and director of the Tumor Microenvironment and Metastasis Program, and director of Academic Affairs, at the Sanford|Burnham Medical Research Institute. She joined OHSU in 2014, where she is an associate director of translational sciences for the Knight Cancer Institute, a professor in the Department of Cell, Developmental and Cancer Biology, and a member of the Center for Spatial Systems Biomedicine. Dr. Courtneidge’s laboratory has studied the Src family of protein tyrosine kinases for a number of years, and has contributed to the understanding of Src transformation, regulation, substrate selection and function. Currently, her research on Src and it substrates focuses on cancer invasion and metastasis, with particular emphasis on the role of membrane structures called podosomes or invadopodia. She also retains an interest in translational research, with the goal of defining novel therapeutic points of intervention for cancer treatment. Dr. Courtneidge’s contributions to cancer research have been recognized with numerous honors, including election to the European Molecular Biology Organization, the Jubilee Lecture and Harden Medal of the British Biochemical Society, the Feodor Lynen Lecture and Lynen Medal, an honorary doctorate from the University of Leeds, and, most recently, the 2015 AACR-WICR Charlotte Friend Memorial Lectureship.
Shinji Iizuka, Ph.D.
Assistant Staff Scientist
Education: Ph.D., 2009 Hiroshima University, Japan; D.D.S., 2005 Kanagawa Dental University Japan
Shinji is an assistant staff scientist in Dr. Courtneidge’s lab. He joined the lab in 2011 and moved with the lab to OHSU in 2014 from Sanford-Burnham Medical Research Institute in La Jolla, CA. His research interest is the regulation of invadopodia in cancer cells and how invadopodia structures regulate cancer progression.
Jose Ceja Navarro, B.S.
Research Assistant 2
Education: B.S., 2015, biology, Oregon State University, Corvallis, OR
Jose was born in Michoacán, Mexico and provides lab support and general lab maintenance. In addition, he is working to uncover the roles of Tks5 in 2D and 3D culture, and finding regulators of invadopodia using a mass spec/proteomics approach. Outside of the lab, Jose enjoys spending time in the outdoors, fishing, hiking and playing billiards.
Kyle Gribbin, B.S.
Research Assistant 2
Education: B.S., 2013, Biology, University of Oregon, Eugene, OR
Kyle was born and raised in Eugene Oregon and moved to Portland after graduating from the University of Oregon. Along with general lab duties, he helps Shinji with maintenance of mouse colonies and investigating the structure and roll of invadopodia in cancer progression. When not in the lab, Kyle enjoys cooking, biking, playing soccer and playing music.