PSR Publications

The following is a selection of publications resulting from PSR projects

Accumulative deamidation of human lens protein γS-crystallin leads to partially unfolded intermediates with enhanced aggregation propensity

Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs

MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract

A miR-494 dependent feedback loop regulates ER stress

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism

A cytoskeletal protein complex is essential for division of intracellular amastigotes of Leishmania mexicana

Altered proteomics profile in the amnion of patients with oligohydramnios

Equivalence of human and bovine dentin matrix molecules for dental pulp regeneration: proteomic analysis and biological function

ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer

Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma

Identification of residues important for M. tuberculosis MmpL11 function reveals that function is modulated by phosphorylation in the C‐terminal domain

Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism

Identification, Quantification, and System Analysis of Protein N‐ε Lysine Methylation in Anucleate Blood Platelets

Glomerular filtrate proteins in acute cardiorenal syndrome

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

Identification of PKCα-dependent phosphoproteins in mouse retina

Cataract-associated deamidations on the surface of γS-crystallin increase protein unfolding and flexibility at distant regions

Multiomics analyses of vesicular transport pathway-specific transcripts and proteins in ovine amnion: responses to altered intramembranous transport

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Investigating β-lactam drug targets in Mycobacterium tuberculosis using chemical probes

Examining the protein interactome and subcellular localization of RNase J2 complexes in Streptococcus mutans

Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) blocks the intrinsic pathway of coagulation, inducing the clearance and degradation of FXIa (Activated Factor XI)

Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Anticancer pyrroloquinazoline LBL1 targets nuclear lamins

Lacrimal gland denervation alters tear protein composition and impairs ipsilateral eye closures and corneal nociception

Combining chemical genetics with proximity-dependent labeling reveals cellular targets of poly (ADP-ribose) polymerase 14 (PARP14)

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

MHC class I loaded ligands from breast cancer cell lines: a potential HLA-I-typed antigen collection

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Microenvironment-mediated mechanisms of resistance to HER2 inhibitors differ between HER2+ breast cancer subtypes

Bidirectional control of coronary vascular resistance by Eicosanoids via a Novel GPCR

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Altered zinc balance in the Atp7b−/− mouse reveals a mechanism of copper toxicity in Wilson disease

Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t (1; 19) pre-B-ALL

Analysis of the proteome of hair-cell stereocilia by mass spectrometry

Increased hemodynamic load in early embryonic stages alters myofibril and mitochondrial organization in the myocardium

The interaction of a Trypanosoma brucei KH-domain protein with a ribonuclease is implicated in ribosome processing

Exosomal trafficking in Xenopus development

Proteomic analysis of the bovine and human ciliary zonule

Extended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue.

Heterodimeric capping protein is required for stereocilia length and width regulationCAPZB controls stereocilia length and width

The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages

GCAP1, Rab6, and HSP27: novel autoantibody targets in cancer-associated retinopathy and autoimmune retinopathy

Natural killer cell evasion is essential for infection by rhesus cytomegalovirus

Identifying family-member-specific targets of mono-ARTDs by using a chemical genetics approach

Identification of a third Mn (II) oxidase enzyme in Pseudomonas putida GB-1

Mycobacterium tuberculosis PPE68 and Rv2626c genes contribute to the host cell necrosis and bacterial escape from macrophages

Modulating the endotheliopathy of trauma: factor concentrate versus fresh frozen plasma

Functional phosphorylation sites in cardiac myofilament proteins are evolutionarily conserved in skeletal myofilament proteins

Annexin A5 is the most abundant membrane-associated protein in stereocilia but is dispensable for hair-bundle development and function

Data detailing the platelet acetyl-lysine proteome

Lysine acetyltransfer supports platelet function

Role for Rab10 in methamphetamine-induced behavior

Hair-bundle proteomes of avian and mammalian inner-ear utricles

Translational tuning optimizes nascent protein folding in cells

The Drosophila helicase maleless (MLE) is implicated in functions distinct from its role in dosage compensation

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events

Solution‐Phase Crosstalk and Regulatory Interactions Between Multipotent Adult Progenitor Cells and Peripheral Blood Mononuclear Cells

Analysis of HIV-1 Gag protein interactions via biotin ligase tagging

LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes

Carbamoylation correlates of cyanate neuropathy and cyanide poisoning: relevance to the biomarkers of cassava cyanogenesis and motor system toxicity

Interaction of Mycobacterium leprae with human airway epithelial cells: adherence, entry, survival, and identification of potential adhesins by surface proteome …

Molecular architecture of the chick vestibular hair bundle

Mechanisms of glucagon degradation at alkaline pH

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Dissection of the Human Multipotent Adult Progenitor Cell Secretome by Proteomic Analysis

Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

Acetaminophen enhances cisplatin-and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma

Novel biomarker candidates to predict hepatic fibrosis in hepatitis C identified by serum proteomics

On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure

Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains

Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity

Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells

Analysis of in situ manganese(II) oxidation in the Columbia River and offshore plume: linking Aurantimonas and the associated microbial community to an active

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypox

De novo proteomics of neuronal ischemic tolerance

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Techniques for accurate protein identification in shotgun proteomic studies of human, mouse, bovine, and chicken lenses

Deamidation alters interactions of β-crystallins in hetero-oligomers

Characterization of the human PANK2 promoter

The membrane proteome of the mouse lens fiber cell

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Human and monkey lenses cultured with calcium ionophore form αB-crystallin lacking the C-terminal lysine, a prominent feature of some human cataracts

Techniques for accurate protein identification in shotgun proteomic studies of human, mouse, bovine, and chicken lenses

Fibrinogen Hershey IV: a novel dysfibrinogen with a γ V411I mutation in the integrin αIIbβ3 binding site

TandTRAQ: an open-source tool for integrated protein identification and quantitation

Interactions of mtFabH with its Substrates and Inhibitors Reveal Novel Mechanistic Insights

Calpain-specific proteolysis in primate retina: contribution of calpains in cell death

Characterization of wheat germin (oxalate oxidase) expressed by Pichia pastoris

Identification and characterization of RHOA-interacting proteins in bovine spermatozoa