MGEN625 is a graduate course in Epigenetics and Reprogramming offered in the Spring quarter. By the end of the course students will understand the classic and modern definitions of epigenetics and the history of the field, know the differences between genetic and epigenetic impact on gene expression, and have a clear understanding of the different epigenetic mechanisms existing in mammals. Moreover, they will learn about phenotypic consequences of normal and abnormal epigenetic regulation on development and disease. Finally, an overview of the effects of environmental factors on epigenetic mechanisms will be provided. This is the only course at OHSU entirely dedicated to epigenetics and reprogramming.