Publications

Molecular basis for maternal inheritance of human mitochondrial DNA

Lee W, Zamudio-Ochoa A, Buchel G, Podlesniy P, Marti Gutierrez N, Puigròs M, Calderon A, Tang HY, Li L, Mikhalchenko A, Koski A, Trullas R, Mitalipov S, Temiakov D. Nature Genetics. PMID: 37723262

The origins and functional effects of postzygotic mutations throughout the human life span

Rockweiler NB, Ramu A, Nagirnaja L, Wong WH, Noordam MJ, Drubin CW, Huang N, Miller B, Todres EZ, Vigh-Conrad KA, Zito A, Small KS, Ardlie KG, Cohen BA, Conrad DF. Science. PMID: 37053313

Limitations of gene editing assessments in human preimplantation embryos

Liang D, Mikhalchenko A, Ma H, Marti Gutierrez N, Chen T, Lee Y, Park SW, Tippner-Hedges R, Koski A, Darby H, Li Y, Van Dyken C, Zhao H, Wu K, Zhang J, Hou Z, So S, Han J, Park J, Kim CJ, Zong K, Gong J, Yuan Y, Gu Y, Shen Y, Olson SB, Yang H, Battaglia D, O'Leary T, Krieg SA, Lee DM, Wu DH, Duell PB, Kaul S, Kim JS, Heitner SB, Kang E, Chen ZJ, Amato P, Mitalipov S. Nature Communication. PMID: 36882397 

 First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility

Costa-Borges N, Nikitos E, Späth K, Miguel-Escalada I, Ma H, Rink K, Coudereau C, Darby H, Koski A, Van Dyken C, Mestres E, Papakyriakou E, De Ziegler D, Kontopoulos G, Mantzavinos T, Vasilopoulos I, Grigorakis S, Prokopakis T, Dimitropoulos K, Polyzos P, Vlachos N, Kostaras K, Mitalipov S, Calderón G, Psathas P, Wells D. Fertility Sterility. PMID: 36787873

Horizontal mtDNA transfer between cells is common during mouse development

Marti Gutierrez N, Mikhalchenko A, Ma H, Koski A, Li Y, Van Dyken C, Tippner-Hedges R, Yoon D, Liang D, Hayama T, Battaglia D, Kang E, Lee Y, Barnes AP, Amato P, Mitalipov S. Horizontal mtDNA transfer between cells is common during mouse development. iScience. PMID: 35243258

Haploidy in somatic cells is induced by mature oocytes in mice

Yeonmi Lee , Aysha Trout , Nuria Marti-Gutierrez, Seoon Kang, Philip Xie, Aleksei Mikhalchenko, Bitnara Kim, Jiwan Choi, Seongjun So, Jongsuk Han, Jing Xu, Amy Koski, Hong Ma, Junchul David Yoon, Crystal Van Dyken, Hayley Darby, Dan Liang, Ying Li, Rebecca Tippner-Hedges, Fuhua Xu, Paula Amato, Gianpiero D Palermo, Shoukhrat Mitalipov, Eunju Kang.  Communication Biology.  PMID: 35079104

Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testis germ cell content, but does not impact fertility in mice.

Houston BJ, O'Connor AE, Wang D, Goodchild G, Merriner DJ, Luan H, Conrad DF, Nagirnaja L, Aston KI, Kliesch S, Wyrwoll MJ, Friedrich C, Tüttelmann F, Harrison C, O'Bryan MK, Walton K. Endocrinology. PMID: 35022746

A de novo paradigm for male infertility.

Oud MS, Smits RM, Smith HE, Mastrorosa FK, Holt GS, Houston BJ, de Vries PF, Alobaidi BKS, Batty LE, Ismail H, Greenwood J, Sheth H, Mikulasova A, Astuti GDN, Gilissen C, McEleny K, Turner H, Coxhead J, Cockell S, Braat DDM, Fleischer K, D'Hauwers KWM, Schaafsma E; Genetics of Male Infertility Initiative (GEMINI) consortium, Nagirnaja L, Conrad DF, Friedrich C, Kliesch S, Aston KI, Riera-Escamilla A, Krausz C, Gonzaga-Jauregui C, Santibanez-Koref M, Elliott DJ, Vissers LELM, Tüttelmann F, O'Bryan MK, Ramos L, Xavier MJ, van der Heijden GW, Veltman JA. Nature Communication. PMID: 35013161 

Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome.

Mahyari E, Guo J, Lima AC, Lewinsohn DP, Stendahl AM, Vigh-Conrad KA, Nie X, Nagirnaja L, Rockweiler NB, Carrell DT, Hotaling JM, Aston KI, Conrad DF. American Journal of Human Genetics. 2021 Oct. PMID: 34626582 

A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships.

Houston BJ, Riera-Escamilla A, Wyrwoll MJ, Salas-Huetos A, Xavier MJ, Nagirnaja L, Friedrich C, Conrad DF, Aston KI, Krausz C, Tüttelmann F, O'Bryan MK, Veltman JA, Oud MS. Human  Reproduction. Update. 2021 Dec 21. PMID: 34498060 

Variant PNLDC1, Defective piRNA Processing, and Azoospermia.

Nagirnaja L, Mørup N, Nielsen JE, Stakaitis R, Golubickaite I, Oud MS, Winge SB, Carvalho F, Aston KI, Khani F, van der Heijden GW, Marques CJ, Skakkebaek NE, Rajpert-De Meyts E, Schlegel PN, Jørgensen N, Veltman JA, Lopes AM, Conrad DF, Almstrup K. New England Journal of Medicine. 2021. PMID: 34347949 

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.

Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O'Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN; GEMINI Consortium. Human Genetics. 2021 Aug. PMID: 33963445 

Lack of evidence for a role of PIWIL1 variants in human male infertility.

Oud MS, Volozonoka L, Friedrich C, Kliesch S, Nagirnaja L, Gilissen C, O'Bryan MK, McLachlan RI, Aston KI, Tüttelmann F, Conrad DF, Veltman JA. Cell. 2021 Apr. PMID: 33861957 

The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse.

Houston BJ, Nagirnaja L, Merriner DJ, O'Connor AE, Okuda H, Omurtag K, Smith C, Aston KI, Conrad DF, O'Bryan MK. Developmental Dynamics. 2021 Jul. PMID: 33442887

Correction to: Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.

Salas-Huetos A, Tüttelmann F, Wyrwoll MJ, Kliesch S, Lopes AM, Gonçalves J, Boyden SE, Wöste M, Hotaling JM; GEMINI Consortium, Nagirnaja L, Conrad DF, Carrell DT, Aston KI. Human Genetics. 2021 Jan. PMID: 33377991 

Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.

Salas-Huetos A, Tüttelmann F, Wyrwoll MJ, Kliesch S, Lopes AM, Goncalves J, Boyden SE, Wöste M, Hotaling JM; GEMINI Consortium, Nagirnaja L, Conrad DF, Carrell DT, Aston KI. Human Genetics. 2021 Jan. PMID: 33211200 

Germline transmission of donor, maternal and paternal mtDNA in primates.

Hong Ma, Crystal Van Dyken, Hayley Darby, Aleksei Mikhalchenko, Nuria Marti-Gutierrez, Amy Koski, Dan Liang, Ying Li, Rebecca Tippner-Hedges, Eunju Kang, Yeonmi Lee, Heather Sidener, Cathy Ramsey, Travis Hodge, Paula Amato, Shoukhrat Mitalipov. Human Reproduction. PMID: 33289786

Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men.

Krausz C, Riera-Escamilla A, Moreno-Mendoza D, Holleman K, Cioppi F, Algaba F, Pybus M, Friedrich C, Wyrwoll MJ, Casamonti E, Pietroforte S, Nagirnaja L, Lopes AM, Kliesch S, Pilatz A, Carrell DT, Conrad DF, Ars E, Ruiz-Castañé E, Aston KI, Baarends WM, Tüttelmann F. Genet Med. 2020 Dec. PMID: 32741963 

Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.

Bustamante-Marin XM, Horani A, Stoyanova M, Charng WL, Bottier M, Sears PR, Yin WN, Daniels LA, Bowen H, Conrad DF, Knowles MR, Ostrowski LE, Zariwala MA, Dutcher SK. PLoS Genetics. 2020 Aug. PMID: 32764743 

The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research.

So S, Lee Y, Choi J, Kang S, Lee JY, Hwang J, Shin J, Dutton JR, Seo EJ, Lee BH, Kim CJ, Mitalipov S, Oh SJ, Kang E. PLoS One. 2020 May 12;15(5):e0233057. PMID: 32396545 

Deleterious mtDNA Mutations are Common in Mature Oocytes.

Ma H, Hayama T, Van Dyken C, Darby H, Koski A, Lee Y, Gutierrez NM, Yamada S, Li Y, Andrews M, Ahmed R, Liang D, Gonmanee T, Kang E, Nasser M, Kempton B, Brigande J, McGill TJ, Terzic A, Amato P, Mitalipov S. Biol Reprod. 2020 Mar 13;102(3):607-619. PMID: 31621839

Reply to: Reversion after replacement of mitochondrial DNA.

Kang E, Koski A, Amato P, Temiakov D, Mitalipov S. Nature. 2019 Oct. PMID: 31619780

Principles of and strategies for germline gene therapy.
Wolf DP, Mitalipov PA, Mitalipov SM. Nat Med. 2019 Jun 3. PMID: 31160821

Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors.
Zhang M, Zhou C, Wei Y, Xu C, Pan H, Ying W, Sun Y, Sun Y, Xiao Q, Yao N, Zhong W, Li Y, Wu K, Yuan G, Mitalipov S, Chen ZJ, Yang H. Genome Biol. 2019 May 22;20(1):101. PMID: 31118069

Therapeutic Genome Editing in Cardiovascular Diseases.
German DM, Mitalipov S, Mishra A, Kaul S.  JACC Basic Transl Sci. 2019 Feb 25;4(1):122-131. PMID: 30847427

Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JCI, Amato P, Mitalipov S. Nature. 2019 Mar;567(7747):E5-E9.  PMID: 30814738

Stage-specific modulation of antimüllerian hormone promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture.

Xu J, Lawson MS, Mitalipov SM, Park BS, Xu F.Fertil Steril. 2018 Nov;110(6):1162-1172. PMID: 30396561 

Ma et al. reply - Brief Communications Arising
Hong Ma, Nuria Marti-Gutierrez, Sang-Wook Park, Jun Wu, Tomonari Hayama, Hayley Darby, Crystal Van Dyken, Ying Li, Amy Koski, Dan Liang, Keiichiro Suzuki, Ying Gu, Jianhui Gong, Xun Xu, Riffat Ahmed, Yeonmi Lee, Eunju Kang, Dongmei Ji, A-Reum Park, Daesik Kim, Sang-Tae Kim, Stephen B. Heitner, David Battaglia, Sacha A. Krieg, David M. Lee, Diana H. Wu, Don P. Wolf, Paula Amato, Sanjiv Kaul, Juan Carlos Izpisua Belmonte, Jin-Soo Kim & Shoukhrat Mitalipov. Nature. online 2018 Aug8. PMID: 30089923

Germline and somatic mtDNA mutations in mouse aging
Ma H, Lee Y, Hayama T, Van Dyken C, Marti-Gutierrez N, Li Y, Ahmed R, Koski A, Kang E, Darby H, Gonmanee T, Park Y, Wolf DP, Jai Kim C, Mitalipov S. PLoS One. 2018 Jul 24;13(7):e0201304. PMID: 30040856

Sarcomere Gene Mutation correction.
Kaul S, Heitner SB, Mitalipov S. Eur Heart J. 2018 May 1. PMID: 29718349

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates.
McGill TJ, Stoddard J, Renner LM, Messaoudi I, Bharti K, Mitalipov S, Lauer A, Wilson DJ, Neuringer M. Invest Ophthalmol Vis Sci. 2018 Mar 1. PMID: 29625461

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs.
Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Proc Natl Acad Sci USA. 2017 Dec 26. PMID: 29203658

Correction of a pathogenic gene mutation in human embryos
Hong Ma, Nuria Marti-Gutierrez, Sang-Wook Park, Jun Wu, Yeonmi Lee, Keiichiro Suzuki, Amy Koski, Dongmei Ji, Tomonari Hayama, Riffat Ahmed, Hayley Darby, Crystal Van Dyken, Ying Li, Eunju Kang, A.-Reum Park, Daesik Kim, Sang-Tae Kim, Jianhui Gong, Ying Gu, Xun Xu, David Battaglia, Sacha A. Krieg, David M. Lee, Diana H. Wu, Don P. Wolf, Stephen B. Heitner, Juan Carlos Izpisua Belmonte, Paula Amato, Jin-Soo Kim, Sanjiv Kaul, Shoukhrat Mitalipov Nature. online 2017 August 2. PMID: 28783728

Mitochondrial genome inheritance and replacement in the human germline 
Wolf DP, Hayama T, Mitalipov S. EMBO Journal 2017 Jul 5. PMID: 28679504
 

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan,  Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee, Tomonari Hayama, Crystal Van Dyken, Xinjian Wang, Shiyu Luo, Riffat Ahmed, Ying Li, Dongmei Ji, Refik Kayali, Cengiz Cinnioglu, Susan Olson, Jeffrey Jensen, David Battaglia, David Lee, Diana Wu, Taosheng Huang, Don P. Wolf, Dmitry Temiakov, Juan Carlos Izpisua Belmonte, Paula Amato, Shoukhrat Mitalipov Nature. 2016 Dec 8. PMID: 27919073

Functional Human Oocytes Generated by Transfer of Polar Body Genomes
Hong Ma, Ryan C. O'Neil, Nuria Marti Gutierrez, Manoj Hariharan, Zhuzhu Z. Zhang, Yupeng He, Cengiz Cinnioglu, Refik Kayali, Eunju Kang, Yeonmi Lee, Tomonari Hayama, Amy Koski, Joseph Nery, Rosa Castanon, Rebecca Tippner-Hedges, Riffat Ahmed, Crystal Van Dyken, Ying Li, Susan Olson, David Battaglia, David M. Lee, Diana H. Wu, Paula Amato, Don P. Wolf, Joseph R. Ecker, and Shoukhrat Mitalipov Cell Stem Cell. online 2016 Nov 10. PMID: 27840020

Anti-Müllerian hormone is produced heterogeneously in the population of primate preantral follicles, and is a potential biomarker for follicle growth and oocyte maturation in vitro.
Xu J, Xu F, Letaw JH, Park BS, Searles RP, Ferguson BM.  Journal of Assisted Reproduction and Genetics. 2016 Sep 15. PMID: 27638727. 

Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer: A Horse in the Race?
Wolf DP, Morey R, Kang E, Ma H, Hayama T, Laurent LC, Mitalipov S. Stem Cells. 2016 Sep 10. Review. PMID: 27612640

Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates.
Xu J, Bishop CV, Lawson MS, Park BS, Xu F.  Human Reproduction. 2016 Jul 31. PMID: 27165618.

Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier. 
Ma H, Marti Gutierrez N, Morey R, Van Dyken C, Kang E, Hayama T, Lee Y, Li Y, Tippner-Hedges R, Wolf DP, Laurent LC, Mitalipov S. Cell Metab. 2016 Jul 13.  PMID: 27425585 

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. 
Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S.      Cell Stem Cell. 2016 May 5;18(5):625-36.  PMID: 27151456

Mitochondria in pluripotent stem cells: stemness regulators and disease targets. 
Folmes CD, Ma H, Mitalipov S, Terzic A. Curr Opin Genet Dev. 2016 Mar 5;38:1-7. PMID:26953561

Metabolic rescue in pluripotent cells from patients with mtDNA disease. 
Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L,Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C,Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP,Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Nature. 2015 Aug13;524(7564):234-8.  PMID: 261769  

Brains, Genes, and Primates
Izpisua Belmonte JC, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F. Neuron. 2015 May 6;86(3):617-31.  PMID: 25950631  

Mitochondrial replacement therapy in reproductive medicine.    
Wolf DP, Mitalipov N, Mitalipov S. Trends Mol Med. 2014 Dec 10.  PMID: 25573721 

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors. 
Johannesson B, Sagi I, Gore A, Paull D, Yamada M, Golan-Lev T, Li Z, LeDuc C, Shen Y, Stern S, Xu N, Ma H, Kang E, Mitalipov S, Sauer MV, Zhang K, Benvenisty N, Egli D. Cell Stem Cell. 2014 Nov 6;15(5):634-42.  PMID: 25517467

Abnormalities in human pluripotent cells due to reprogramming mechanisms. 
Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed1 R, Gutierrez  NM, Van Dyken1 C, Polat  A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent LC & Mitalipov S. Nature. 2014 Jul 10;511(7508):177-83. PMID:25008523

Mitochondrial Replacement Therapies Can Circumvent mtDNA-Based Disease Transmission.  
Wolf DP and Mitalipov SM. Cell Metabolism, 2014 Jul 1;20(1):6-8.  PMID:24988456

Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases.
Mitalipov S, Amato P, Parry S, Falk MJ. Cell Rep. 2014 May 22;7(4):935-7. PMID:24856294

Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos.   
Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Schöler HR, Mitalipov S.   Nature. 2014 May 1;509(7498):101-4.  PMID:24670652

The challenges of mitochondrial replacement.  
Chinnery PF, Craven L, Mitalipov S, Stewart JB, Herbert M, Turnbull DM. PLoS Genet. 2014 Apr 24;10(4):e1004315.   PMID: 24762741

Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features.  
Daughtry B, Mitalipov S. Stem Cells Transl Med. 2014 Mar;3(3):290-8.  PMID: 24443005

Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases.
Amato P, Tachibana M, Sparman M, Mitalipov S. Fertil Steril. 2014 Jan;101(1):31-5. Review. PMID: 24382342

Clinical and ethical implications of mitochondrial gene transfer. 
Mitalipov S, Wolf DP. Trends Endocrinol Metab. 2014 Jan;25(1):5-7. PMID: 24373414

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.
Janovick JA, Stewart MD, Jacob D, Martin LD, Deng JM, Stewart CA, Wang Y, Cornea A, Chavali L, Lopez S, Mitalipov S, Kang E, Lee HS, Manna PR, Stocco DM, Behringer RR, Conn PM. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21030-5. PMID: 24324164. PMCID: PMC3876212.

Cloning Primates.
Simerly C, Tachibana M, Mitalipov S. and Schatten G. In: Principles of Cloning. Second Edition. Edited by José Cibelli, John Gurdon, Ian Wilmut, Rudolf Jaenisch, Robert Lanza, Michael D. West and Keith H.S. Campbell. Academic Press, Elsevier. 2013. ISBN: 978-0-12-386541-0

Primate and Human Somatic Cell Nuclear Transfer.
Cervera RP, Mitalipov SM. In: Biology and Pathology of the Oocyte - Role in Fertility, Medicine and Nuclear Reprograming. 2nd Edition. Edited by Alan Trounson, Roger Gosden and Ursula Eichenlaub-Ritter. Cambridge University Press. 2013. ISBN: 9781107021907

Human embryonic stem cells derived by somatic cell nuclear transfer.
Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Cell. 2013 Jun 6;153(6):1228-38. PMID: 23683578. PMCID: PMC3772789.

Stem cell potency and the ability to contribute to chimeric organisms.
Polejaeva I, Mitalipov S. Reproduction. 2013 Mar 7;145(3):R81-8. doi: 10.1530/REP-12-0396. Print 2013 Mar 1. Review. PMID: 23221011. PMCID: PMC3678546

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm.
Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MC, Schatten GP, Mitalipov S, Orwig KE. Cell Stem Cell. 2012 Nov 2;11(5):715-26. PMID: 23122294

Towards germline gene therapy of inherited mitochondrial diseases.
Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Nature. 2012 Oct 24. [Epub ahead of print]. PMID: 23103867

X-chromosome inactivation in monkey embryos and pluripotent stem cells.
Tachibana M, Ma H, Sparman ML, Lee HS, Ramsey CM, Woodword JS, Sritanaudomchai H, Masterson KR, Wolff EE, Jia Y, Mitalipov SM. Dev Biol. 2012 Nov 15;371(2):146-55. doi: 10.1016/j.ydbio.2012.08.009. Epub 2012 Aug 23.

Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.
Lee HS, Ma H, Juanes RC, Tachibana M, Sparman M, Woodward J, Ramsey C, Xu J, Kang EJ, Amato P, Mair G, Steinborn R, and Mitalipov S.  Cell Reports, 03 May 2012

Chromosome transfer in mature oocytes.
Tachibana M, Sparman M, Mitalipov S. Fertil Steril. 2012 May;97(5):e16.

Generation of chimeric rhesus monkeys.
Tachibana M, Sparman M, Ramsey C, Ma H, Lee HS, Penedo MC, Mitalipov S. Cell. 2012 Jan 20;148(1-2):285-95.

Cloning of non-human primates: the road "less traveled by".
Sparman ML, Tachibana M, and Mitalipov SM. Int. J. Dev. Biol. 2010; 54: 1671-1678

Systems biology discoveries using non-human primate pluripotent stem and germ cells: novel gene and genomic imprinting interactions as well as unique expression patterns.
Ben-Yehudah A, Easley CA 4th, Hermann BP, Castro C, Simerly C, Orwig KE, Mitalipov S, Schatten G. Stem Cell Res Ther. 2010 Aug 5;1(3):24.

Chromosome transfer in mature oocytes.
Tachibana M, Sparman M, Mitalipov S. Nat Protoc. 2010;5(6):1138-47.

Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells.
Sritanaudomchai H, Ma H, Clepper L, Gokhale S, Bogan R, Hennebold J, Wolf D, Mitalipov S. Hum Reprod. 2010 Aug;25(8):1927-41.

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.
Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagège A, Desnos M, Renaud JF, Menasché P, Pucéat M. J Clin Invest. 2010 Apr 1;120(4):1125-39

DNA methylation programming and reprogramming in primate embryonic stem cells.
Cohen NM, Dighe V, Landan G, Reynisdóttir S, Palsson A, Mitalipov S, Tanay A. Genome Res. 2009 Dec;19(12):2193-201.

CDX2 in the formation of the trophectoderm lineage in primate embryos.
Sritanaudomchai H, Sparman M, Tachibana M, Clepper L, Woodward J, Gokhale S, Wolf D, Hennebold J, Hurlbut W, Grompe M, Mitalipov S. Dev Biol. 2009 Nov 1;335(1):179-87.

Mitochondrial gene replacement in primate offspring and embryonic stem cells.
Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S. Nature. 2009 Sep 17;461(7262):367-72.

Epigenetic reprogramming by somatic cell nuclear transfer in primates.
Sparman M, Dighe V, Sritanaudomchai H, Ma H, Ramsey C, Pedersen D, Clepper L, Nighot P, Wolf D, Hennebold J, Mitalipov S. Stem Cells. 2009 Jun;27(6):1255-64.

Developmental biology: Transgenic primate offspring.
Schatten G, Mitalipov S. Nature. 2009 May 28;459(7246):515-6.

Totipotency, pluripotency and nuclear reprogramming.
Mitalipov S, Wolf D. Adv Biochem Eng Biotechnol. 2009;114:185-99

Pluripotent stem cells: maintenance of genetic and epigenetic stability and prospects of cell technologies.
Gordeeva OF, Mitalipov SM. Ontogenez. 2008 Nov-Dec;39(6):405-19.

Methods in stem cell research.
Mitalipov S, Wolf DP. Methods. 2008 Jun;45(2):99-100.

Gene targeting in adult rhesus macaque fibroblasts.
Meehan DT, Zink MA, Mahlen M, Nelson M, Sanger WG, Mitalipov SM, Wolf DP, Ouellette MM, Norgren RB Jr. BMC Biotechnol. 2008 Mar 26;8:31

Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes.
Dighe V, Clepper L, Pedersen D, Byrne J, Ferguson B, Gokhale S, Penedo MC, Wolf D, Mitalipov S. Stem Cells. 2008 Mar;26(3):756-66. 

Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology.
In: Sourcebook of models for biomedical research. Wolf DP, Mitalipov SM, Byrne JA. Edited by P. Michael Conn. Springer-Verlag New York, LLC. January 2008. SBN-13:9781597452854. 397-404

Producing primate embryonic stem cells by somatic cell nuclear transfer.
Byrne JA, Pedersen DA, Clepper LL, Nelson M, Sanger WG, Gokhale S, Wolf DP, Mitalipov SM. Nature. 2007 Nov 22;450(7169):497-502.  

Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling.
Mitalipov SM, Zhou Q, Byrne JA, Ji WZ, Norgren RB, Wolf DP. Hum Reprod. 2007 Aug;22(8):2232-42.

Evaluation of the vervet (Clorocebus aethiops) as a model for the assisted reproductive technologies.
Sparman ML, Ramsey CM, Thomas CM, Mitalipov SM, Fanton JW, Maginnis GM, Stouffer RL, Wolf DP. Am J Primatol. 2007 Aug;69(8):917-29.

Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo.
Sritanaudomchai H, Pavasuthipaisit K, Kitiyanant Y, Kupradinun P, Mitalipov S, Kusamran T. Mol Reprod Dev. 2007 Oct;74(10):1295-302.

Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF. Stem Cells. 2007 Feb;25(2):490-9. 

Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells.
Mitalipov S, Clepper L, Sritanaudomchai H, Fujimoto A, Wolf D. Stem Cells. 2007 Mar;25(3):581-8. Epub 2006 Dec 1. 

Nuclear transfer in non-human primates. Mitalipov SM, Wolf DP. In: Nuclear transfer protocols: Cell reprogramming and transgenesis. Methods in Molecular Biology.
Human Press. Edited by Verma PJ and Trounson AO. June 2006. ISBN: 1-58829-280-0

Genomic imprinting in primate embryos and embryonic stem cells.
Mitalipov SM. Reprod Fertil Dev. 2006;18(8):817-21.

Nuclear transfer in nonhuman primates.
Mitalipov SM, Wolf DP. Methods Mol Biol. 2006;348:151-68.

Transcriptional profiling of rhesus monkey embryonic stem cells.
Byrne JA, Mitalipov SM, Clepper L, Wolf DP. Biol Reprod. 2006 Dec;75(6):908-15. Epub 2006 Aug 30.

A comparative approach to somatic cell nuclear transfer in the rhesus monkey.
Zhou Q, Yang SH, Ding CH, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP, Ji WZ. Hum Reprod. 2006 Oct;21(10):2564-71. Epub 2006 Jun 22.

Isolation and characterization of novel rhesus monkey embryonic stem cell lines.
Mitalipov S, Kuo HC, Byrne J, Clepper L, Meisner L, Johnson J, Zeier R, Wolf D. Stem Cells. 2006 Oct;24(10):2177-86.

Aberrant genomic imprinting in rhesus monkey embryonic stem cells.
Fujimoto A, Mitalipov SM, Kuo HC, Wolf DP. Stem Cells. 2006 Mar;24(3):595-603.

Cell cycle features of primate embryonic stem cells.
Fluckiger AC, Marcy G, Marchand M, Négre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C. Stem Cells. 2006 Mar;24(3):547-56.

Current progress with primate embryonic stem cells.
Byrne JA, Mitalipov SM, Wolf DP. Curr Stem Cell Res Ther. 2006 May;1(2):127-38

Low temperature storage of rhesus monkey spermatozoa and fertility evaluation by intracytoplasmic injection.
Yeoman RR, Mitalipov S, Gerami-Naini B, Nusser KD, Wolf DP. Theriogenology. 2005 Jun;63(9):2356-71.

Development of a monkey model for the study of primate genomic imprinting.
Fujimoto A, Mitalipov SM, Clepper LL, Wolf DP. Mol Hum Reprod. 2005 Jun;11(6):413-22

Use of assisted reproductive technologies in the propagation of rhesus macaque offspring.
Wolf DP, Thormahlen S, Ramsey C, Yeoman RR, Fanton J, Mitalipov S. Biol Reprod. 2004 Aug;71(2):486-93

Oct-4 expression in pluripotent cells of the rhesus monkey.
Mitalipov SM, Kuo HC, Hennebold JD, Wolf DP. Biol Reprod. 2003 Dec;69(6):1785-92. Epub 2003 Jul 30.

Differentiation of monkey embryonic stem cells into neural lineages.
Kuo HC, Pau KY, Yeoman RR, Mitalipov SM, Okano H, Wolf DP. Biol Reprod. 2003 May;68(5):1727-35.

The mammalian blastocysts as an experimental model.
Mitalipov SM, Kuo HC, Wolf DP. In: An atlas of human blastocysts. The Parthenon Publishing Group. New York, NY. Edited by Veeck LL and Zaninovic N. 2003. 231-250

Monozygotic twinning in rhesus monkeys by manipulation of in vitro-derived embryos.
Mitalipov SM, Yeoman RR, Kuo HC, Wolf DP. Biol Reprod. 2002 May;66(5):1449-55.

Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells.
Mitalipov SM, Yeoman RR, Nusser KD, Wolf DP. Biol Reprod. 2002 May;66(5):1367-73.

Cloning mammals.
Wolf DP, Mitalipov SM. In: Assisted Reproductive Technology. Accomplishments and New Horizons. Published by Cambridge University Press. Cambridge CB2 2RU. Edited by Christopher J. De Jonge and Christopher L.R. Barratt, 2002. 206-216

Nuclear transfer technology in mammalian cloning.
Wolf DP, Mitalipov S, Norgren RB Jr. Arch Med Res. 2001 Nov-Dec;32(6):609-13. Review.

Cryoloop vitrification yields superior survival of Rhesus monkey blastocysts.
Yeoman RR, Gerami-Naini B, Mitalipov S, Nusser KD, Widmann-Browning AA, Wolf DP. Hum Reprod. 2001 Sep;16(9):1965-9.

Parthenogenetic activation of rhesus monkey oocytes and reconstructed embryos.
Mitalipov SM, Nusser KD, Wolf DP. Biol Reprod. 2001 Jul;65(1):253-9.

Developmental competence of oocytes after ICSI in the rhesus monkey.
Nusser KD, Mitalipov S, Widmann A, Gerami-Naini B, Yeoman RR, Wolf DP. Hum Reprod. 2001 Jan;16(1):130-137.

Application of ARTs and nuclear transfer in exotic or endangered species.
White K L, Bunch T D, Mitalipov SM , Reed WA. In: Assisted fertilization and nuclear transfer in mammals. Series in Contemporary Endocrinology published by Humana Press. Edited by: D. Wolf and M. Zelinski-Wooten. 2001. 239-252

Mammalian cloning: possibilities and threats.
Mitalipov SM, Wolf DP. Ann Med. 2000 Oct;32(7):462-8