Shoukhrat Mitalipov, PhD
Dr. Mitalipov earned his Ph.D. degree in 1994 in Developmental & Stem Cell Biology at the Research Center for Medical Genetics, Moscow, Russia. He came to Utah State University in 1995 to conduct postdoctoral research training and then moved to Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University. In 2014. Dr, Mitalipov became the director of the newly founded Center for Embryonic Cell and Gene Therapy. He is also a Senior Scientist in the Division of Reproductive & Developmental Sciences of ONPRC and Professor in Departments of Biomedical Engineering, Obstetrics, Gynecology & Pediatrics, and Molecular & Medical Genetics, School of Medicine, OHSU. He is the recipient of the 2010 Discovery Award from the Medical Research Foundation of Oregon.
Hong Ma, MD, PhD
I received my MD from Xi'An Medical University in China and PhD in Molecular Biology from Kyoto University in Japan where I studied the molecular mechanisms of the protease function and protease regulation by inhibitors in tissues and cells. I worked in at School of Dentistry in OHSU for 13 years before joining the Mitalipov lab in 2008. I am currently a Staff Scientist and responsible for management of the stem cell and molecular biology lab. My research project is focused on mitochondrial gene replacement and stem cell therapies for mitochondrial diseases.
I earned my bachelor's degree in biology and chemistry from Carroll College in Helena, MT. At the University of Washington, I was part of a research team that focused on lung disease and injury, while at the University of Virginia my research focus was on the blood-brain barrier and the role of respiratory depressants. In 2014, I joined Dr. Mitalipov's center as Clinical Research Coordinator and assumed additional administrative responsibilities as the Center Manager in 2016. I am responsible for clinical, administrative and research activities related to the management of patients and volunteers on clinical research studies and clinical trials, including assisting in ongoing regulatory efforts at the local and federal levels. I oversee patient recruitment, maintenance and submission of patient data; assist with experimental protocol activities; maintenance and preparation of all audits, management all regulatory submissions and committee documents including DSMC, IRB, and grant applications. I also continue to assist in the lab with cell culture, library preparation and cell isolation protocols.
Senior Research Associate
Nuria Marti-Gutierrez, PhD
I received my Master's degree in Clinical Biology and Reproduction from the University of Alicante and my PhD, under the direction of Dr. Mitalipov, from the University of Valencia. During my PhD studies I investigated somatic cell nuclear transfer (SCNT) in porcine and mitochondrial replacement in mouse and human. I joined Dr. Mitalipov's lab in February 2012. I'm currently a Senior Research Associate and the Embryology Manager of the Center for Embryonic Cell and Gene Therapy. My research projects are focused on germ line gene correction.
Dan Liang, PhD
I received my master's degree and PhD from Shanghai institute of Biochemistry and Cell Biology, Chinese Academy of Science in 2016. My doctoral thesis has been focused on the study of genetic and epigenetic regulations in pre-implantation embryos using micromanipulation techniques and construction of gene modification mice via CRISPR-Cas9. I joined Dr. Mitalipovs' lab in February 2017. My research here is focused on the stability of the mitochondrial DNA in mammalian gametes, embryos and stem cells.
I received my master’s degree in Bioengineering and Bioinformatics from Moscow State University, and my Ph.D. degree in Life Sciences from Skolkovo Institute of Science and Technology. As a visiting scholar from Skoltech, I conducted my graduate training at Brigham and Women’s Hospital, Harvard Medical School, working on induced pluripotent stem cells and comparative biology of aging. My research interests in stem cells and reproductive medicine, and desire to work closer to a clinical setting brought me to the OHSU Center for Embryonic Cell and Gene Therapy, which I joined as a postdoctoral research fellow in 2019. My projects here are focused on cell-based mitochondrial replacement therapies.
I received my B.S. in Biology and Ph.D. in Anatomy and Structural Biology from Mahidol University, Thailand. My doctoral thesis is a study of neuronal differentiation of stem cells derived from human dental pulp and interaction between them and brainstem slices. I was a visiting student in Dr. Mitalipov’s center to learn embryonic stem cells and gene therapy work. I joined the Center as a postdoctoral fellow in February 2019. My research focus is next generation assisted reproductive technology.
The indispensable crew
I received my B.S. degree in Micro/Molecular Biology from Portland State University and an A.A.S. degree from Portland Community College in Biotechnology. My passion is Developmental Biology. My senior year research thesis was in primitive hematopoiesis at OHSU. I joined the Mitalipov lab Embryonic Stem Cell group in 2012 and my research focus is in Somatic Mitochondrial DNA Mutations and Mitochondrial replacement therapy.
I joined the Mitalipov lab in 2016 bringing a background in genomics and molecular biology. I am the most recent addition to the research assistant team and provide support to mitochondrial genetic and stem cell research. I hold a Master of Science degree from the University of British Columbia and a Bachelor of Arts from Portland State.
I received my BS from Shanghai Medical University in China and obtained my MS from Duquesne University in Pittsburgh, PA. I worked as a research assistant at the Vollum Institute at OHSU for two years before I joined the Mitalipov lab as a research assistant in 2008.
Crystal Van Dyken
I received my B.S. in Biology from the University of Idaho in 2009. I previously worked as a research technician in the Pharmacology Department at Washington State University. I joined the Mitalipov lab as a Research Assistant in 2013. I assist with many projects and my primary focuses are on embryology and molecular biology as well as maintaining the lab's IACUC protocol.
Throughout my professional life, I’ve enjoyed building partnerships & solving problems, improving client experiences and helping others succeed, as well as helping to bring to fruition projects which enhance life for the community. Curiosity and passion for life took me around the world and to industries as diverse as the Fine Arts and the Financial Industry Regulatory environment. Driven by desire to be a part of something bigger and more important than “business as usual”, I am thrilled to join Dr. Mitalipov’s Center as an Administrative Coordinator and to provide backstage support to scientists. I hold a Bachelor of Science degree in Arts Administration from CUNY Baccalaureate Program, Baruch College in New York.