Shoukhrat Mitalipov, PhD
Dr. Mitalipov earned his Ph.D. degree in 1994 in Developmental & Stem Cell Biology at the Research Center for Medical Genetics, Moscow, Russia. He came to Utah State University in 1995 to conduct postdoctoral research training and then moved to Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University. In 2014. Dr, Mitalipov became the director of the newly founded Center for Embryonic Cell and Gene Therapy. He is also a Senior Scientist in the Division of Reproductive & Developmental Sciences of ONPRC and Professor in Departments of Biomedical Engineering, Obstetrics, Gynecology & Pediatrics, and Molecular & Medical Genetics, School of Medicine, OHSU. He is the recipient of the 2010 Discovery Award from the Medical Research Foundation of Oregon.
Hong Ma, MD, PhD
I received my MD from Xi'An Medical University in China and PhD in Molecular Biology from Kyoto University in Japan where I studied the molecular mechanisms of the protease function and protease regulation by inhibitors in tissues and cells. I worked in at School of Dentistry in OHSU for 13 years before joining the Mitalipov lab in 2008. I am currently a Staff Scientist and responsible for management of the stem cell and molecular biology lab. My research project is focused on mitochondrial gene replacement and stem cell therapies for mitochondrial diseases.
I earned my bachelor's degree in biology and chemistry from Carroll College in Helena, MT. At the University of Washington, I was part of a research team that focused on lung disease and injury, while at the University of Virginia my research focus was on the blood-brain barrier and the role of respiratory depressants. In 2014, I joined Dr. Mitalipov's center as Clinical Research Coordinator and assumed additional administrative responsibilities as the Center Manager in 2016. I am responsible for clinical, administrative and research activities related to the management of patients and volunteers on clinical research studies and clinical trials, including assisting in ongoing regulatory efforts at the local and federal levels. I oversee patient recruitment, maintenance and submission of patient data; assist with experimental protocol activities; maintenance and preparation of all audits, management all regulatory submissions and committee documents including DSMC, IRB, and grant applications. I also continue to assist in the lab with cell culture, library preparation and cell isolation protocols.
Senior Research Associate
Nuria Marti-Gutierrez, PhD
I received my Master's degree in Clinical Biology and Reproduction from the University of Alicante and my PhD, under the direction of Dr. Mitalipov, from the University of Valencia. During my PhD studies I investigated somatic cell nuclear transfer (SCNT) in porcine and mitochondrial replacement in mouse and human. I joined Dr. Mitalipov's lab in February 2012. I'm currently a Senior Research Associate and the Embryology Manager of the Center for Embryonic Cell and Gene Therapy. My research projects are focused on germ line gene correction.
Dan Liang, PhD
I received my master's degree and PhD from Shanghai institute of Biochemistry and Cell Biology, Chinese Academy of Science in 2016. My doctoral thesis has been focused on the study of genetic and epigenetic regulations in pre-implantation embryos using micromanipulation techniques and construction of gene modification mice via CRISPR-Cas9. I joined Dr. Mitalipovs' lab in February 2017. My research here is focused on the stability of the mitochondrial DNA in mammalian gametes, embryos and stem cells.
Aleksei Mikhalchenko, PhD
I received my master’s degree in Bioengineering and Bioinformatics from Moscow State University, and my Ph.D. degree in Life Sciences from Skolkovo Institute of Science and Technology. As a visiting scholar from Skoltech, I conducted my graduate training at Brigham and Women’s Hospital, Harvard Medical School, working on induced pluripotent stem cells and comparative biology of aging. My research interests in stem cells and reproductive medicine, and desire to work closer to a clinical setting brought me to the OHSU Center for Embryonic Cell and Gene Therapy, which I joined as a postdoctoral research fellow in 2019. My projects here are focused on cell-based mitochondrial replacement therapies.
The indispensable crew
I joined the Mitalipov lab in 2016 bringing a background in genomics and molecular biology. I am the most recent addition to the research assistant team and provide support to mitochondrial genetic and stem cell research. I hold a Master of Science degree from the University of British Columbia and a Bachelor of Arts from Portland State.
I received my BS from Shanghai Medical University in China and obtained my MS from Duquesne University in Pittsburgh, PA. I worked as a research assistant at the Vollum Institute at OHSU for two years before I joined the Mitalipov lab as a research assistant in 2008.
Crystal Van Dyken
I received my B.S. in Biology from the University of Idaho in 2009. I previously worked as a research technician in the Pharmacology Department at Washington State University. I joined the Mitalipov lab as a Research Assistant in 2013. I assist with many projects and my primary focuses are on embryology and molecular biology as well as maintaining the lab's IACUC protocol.
I started my career in academic research in 1998 while completing my Bachelor’s degree at Oregon State University in a plant pathology lab. I then went on to complete a professional Masters in Biotechnology from the Cell and Molecular Biology Department of OSU in 2007 and work for the Oregon Department of Agriculture, the University of Oregon monoclonal antibody facility, and then entered a few biotech positions. I first started in the Mitalipov lab in 2011, left between 2016 and 2019, and have recently returned, specializing in stem cell culture.