Principle Investigator and Program Director
Jeanne-Marie Guise, MD, MPH
Jeanne-Marie Guise, M.D., M.P.H., is Professor of Obstetrics & Gynecology, Emergency Medicine, Medical Informatics & Clinical Epidemiology at OHSU and the OHSU-PSU School of Public Health. She is Director of the Scientific Resource Center for the AHRQ Evidence-based Practice Centers program and Associate Director of the US Cochrane. Dedicated to training and mentoring, she runs several research training programs, including a new program focused on patient-centered learning health systems in partnership with Dr. Lucy Savitz of Kaiser Permanente NW Center for Health Research. In 2018, she was appointed Director of the newly-created OHSU Physician-Scientist Program. She has been involved in the Oregon BIRCWH program since 2008 and has served as Principal Investigator/Program Director since 2012. Improving healthcare quality and patient safety is a critical focus of her research, clinical care, and leadership. She has almost 20 years of continuous federally funded research in women and children’s health, ranging from community-based research and epidemiological studies to evidence reviews and technology.
Basic Science Research Director
Les Myatt, PhD, FRCOG
Les Myatt, Ph.D., FRCOG, is the Bob and Charlee Moore endowed professor within the OHSU Bob and Charlee Moore Institute for Nutrition & Wellness. He is professor of Obstetrics and Gynecology in the OHSU School of Medicine as well as the Director of Perinatal Research in the Department of Obstetrics and Gynecology. Dr. Myatt also serves as Director of the Placental Origins of Disease Group within the OHSU Knight Cardiovascular Institute's Center for Developmental Health. His research applies basic science approaches to clinical problems in perinatology, including preeclampsia, preterm birth and gestational diabetes. His research interests include control of fetal placental vascular reactivity, the role of obesity, oxidative and nitrative stress in placental function and fetal programming and the regulation of prostaglandin synthesis and action in intrauterine tissues at parturition. His current work focuses on the role of maternal adiposity on epigenetic regulation of placental function and on the placental mitochondrial energetics.