The core provides access to a TECAN Spark Multi-mode plate reader and a SpectraMax M Series multi-Mode microplate reader. The TECAN Spark Multi-mode plate reader is capable of

• Absorbance – incl. UV/VIS spectra
• Fluorescence top & bottom - incl. spectra
• Time resolved fluorescence (TRF) – incl. spectra
• FRET
• TR-FRET
• Fluorescence Polarization (FP)
• Luminescence – glow, flash, multicolor, spectra
• Automatic injections

 In addition the Core has a CARY Eclipse fluorescence spectrophotometer equipped with capacity for temperature and time spectrum acquisition in 4 cuvettes at multiple wavelengths. The Cary fluorimeter provides the user with superior sensitive data collection, with enhanced sampling capabilities and excellent reliability. Together these instruments offer users:

• A unique uncompromised combination of filters to provide sensitivity and a monochromator for wavelength flexibility,
• The ability to get rapid absorbance readouts with a high speed monochromator.
• The option of precise temperature control during assay development by using a unique thermoelectric cooling module.
• High sensitivity, uniformity and linearity for assays with unique temperature sensing and correction, plus pre-set filter settings for specific experiments such as measuring the thermodynamics and kinetics of binding, analyzing enzyme activity kinetics, ELISA, Cell-based fluorescence studies and thermo-stability of biologics
• The ability to obtain rapid kinetics using a temperature controlled, with a pneumatic driven RX2000 stopped flow attachment with a dead-time of only 8 ms.  The flow cells has dual path lengths of 2 and 10 mm, with per-shot volume of 120 ml.