Principal Investigator

Mitalipov 2

Shoukhrat Mitalipov, PhD

Dr. Mitalipov earned his Ph.D. degree in 1994 in Developmental & Stem Cell Biology at the Research Center for Medical Genetics, Moscow, Russia. He came to Utah State University in 1995 to conduct postdoctoral research training and then moved to Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University. In 2014. Dr, Mitalipov became the director of the newly founded Center for Embryonic Cell and Gene Therapy. He is also a Senior Scientist in the Division of Reproductive & Developmental Sciences of ONPRC and Professor in Departments of Biomedical Engineering, Obstetrics, Gynecology & Pediatrics, and Molecular & Medical Genetics, School of Medicine, OHSU. He is the recipient of the 2010 Discovery Award from the Medical Research Foundation of Oregon.

Staff Scientist


Hong Ma, MD, PhD

I received my MD from Xi'An Medical University in China and PhD in Molecular Biology from Kyoto University in Japan where I studied the molecular mechanisms of the protease function and protease regulation by inhibitors in tissues and cells. I worked in at School of Dentistry in OHSU for 13 years before joining the Mitalipov lab in 2008. I am currently a Staff Scientist and responsible for management of the stem cell and molecular biology lab. My research project is focused on mitochondrial gene replacement and stem cell therapies for mitochondrial diseases.

Center Manager


Amy Koski

I earned my bachelor's degree in biology and chemistry from Carroll College in Helena, MT. At the University of Washington, I was part of a research team that focused on lung disease and injury, while at the University of Virginia my research focus was on the blood-brain barrier and the role of respiratory depressants. In 2014, I joined Dr. Mitalipov's center as Clinical Research Coordinator and assumed additional administrative responsibilities as the Center Manager in 2016. I am responsible for clinical, administrative and research activities related to the management of patients and volunteers on clinical research studies and clinical trials, including assisting in ongoing regulatory efforts at the local and federal levels. I oversee patient recruitment, maintenance and submission of patient data; assist with experimental protocol activities; maintenance and preparation of all audits, management all regulatory submissions and committee documents including DSMC, IRB, and grant applications. I also continue to assist in the lab with cell culture, library preparation, and cell isolation protocols.

Finance and Administrative Manager

Hoa Vu

Hoa Vu, CPA

I received my Bachelor of Science in Accounting from Portland State University and was licensed as a Certified Public Accountant in 2017. I came to OHSU in 2004 as a Finance Administrator for Department of Emergency Medicine and joined Dr. Mitalipov's Lab in January 2018. I support the Lab on all financial and administrative matters and am very happy to be part of the team.

Senior Research Associate


Nuria Marti-Gutierrez, PhD

I received my Master's degree in Clinical Biology and Reproduction from the University of Alicante and my PhD, under the direction of Dr. Mitalipov, from the University of Valencia. During my PhD studies I investigated somatic cell nuclear transfer (SCNT) in porcine and mitochondrial replacement in mouse and human. I joined Dr. Mitalipov's lab in February 2012. I'm currently a Senior Research Associate and the Embryology Manager of the Center for Embryonic Cell and Gene Therapy. My research projects are focused on germ line gene correction.

Postdoctoral Fellow


Tomonari Hayama, MD, PhD

I received my MD from Yokohama City University in 2003 and PhD from Center for Stem Cell Biology and Regenerative Medicine, Tokyo University in 2014. During my PhD studies, I investigated the mechanisms of germ cell development from reprogramed pluripotent stem cells in mouse and rat models. I joined Dr. Mitalipov as a postdoctoral fellow in May of 2014. I am interested in germ cell, embryo, developmental biology and mitochondrial genetics. My research here is focused on mitochondrial genetics in mitochondrial disease.

Dan Liang

Dan Liang, PhD

I received my master's degree and PhD from Shanghai institute of Biochemistry and Cell Biology, Chinese Academy of Science in 2016. My doctoral thesis has been focused on the study of genetic and epigenetic regulations in pre-implantation embryos using micromanipulation techniques and construction of gene modification mice via CRISPR-Cas9. I joined Dr. Mitalipovs' lab in February 2017. My research here is focused on the stability of the mitochondrial DNA in mammalian gametes, embryos and stem cells.

The Indispensable Crew


Riffat Ahmed

I received my B.S. degree in Micro/Molecular Biology from Portland State University and an A.A.S. degree from Portland Community College in Biotechnology. My passion is Developmental Biology. My senior year research thesis was in primitive hematopoiesis at OHSU. I joined the Mitalipov lab Embryonic Stem Cell group in 2012 and my research focus is in Somatic Mitochondrial DNA Mutations and Mitochondrial replacement therapy.


Ying Li

I received my BS from Shanghai Medical University in China and obtained my MS from Duquesne University in Pittsburgh, PA. I worked as a research assistant at the Vollum Institute at OHSU for two years before I joined the Mitalipov lab as a research assistant in 2008.


Crystal Van Dyken

I received my B.S. in Biology from the University of Idaho in 2009. I previously worked as a research technician in the Pharmacology Department at Washington State University. I joined the Mitalipov lab as a Research Assistant in 2013. I assist with many projects and my primary focuses are on embryology and molecular biology as well as maintaining the lab's IACUC protocol.

Hayley Darby photo

Hayley Darby

I joined the Mitalipov lab in 2016 bringing a background in genomics and molecular biology. I am the most recent addition to the research assistant team and provide support to mitochondrial genetic and stem cell research. I hold a Master of Science degree from the University of British Columbia and a Bachelor of Arts from Portland State.