Pioneering personalized medicine research in human gene correction, mitochondrial replacement therapy (MRT), human embryonic stem cells (hESC), induced pluripotent stem cells (iPS) & somatic cell nuclear transfer (SCNT) Support our Lab
In the News
Gene-Editing Technique in Human Embryos Draws Skepticism. The Wall Street Journal Critics challenge a study saying a disease-causing gene
mutation was repaired in human embryos
Profiles in precision medicine Advances in DNA testing and gene editing have given people choices that would have been impossible a few decades ago. Here, in their own words (including Dr. Paula Amato), are the stories of four people confronted with these dilemmas.
SCIENTISTS TAKE A HARDER LOOK AT GENETIC ENGINEERING OF HUMAN EMBRYOS. WIRED Genetic modification of human embryos is controversial for obvious reasons—and less obvious ones, like whether it really works.
Study verifies gene repair breakthrough. OHSU News. Research published in Nature confirms discovery of DNA repair mechanism
Science News editors have identified "CRISPR gene editing moves into humans, spurs debate" as their Number 2 story of 2017. OHSU scientists Shoukhrat Mitalipov and Paula Amato's CRISPR research was one of @ScienceNews' top stories of 2017! #SNTop10
Mitalipov successfully repairs genes in human embryos
A ground breaking discovery by Shoukhrat Mitalipov, Ph.D., was reported in Nature —the successful removal of a lethal genetic defect in human embryos. The breakthrough is the initial confirmation that a dangerous genetic defect can in theory be erased.
New research provides key insight about mitochondrial replacement therapy
A new discovery may unlock the answer to a vexing scientific question: How to conduct mitochondrial replacement therapy, a new gene-therapy technique, in such a way that safely prevents the transmission of harmful mitochondrial gene mutations from mothers to their children.
New Technique could increase success of infertility treatment
Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies.