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Tissue Remodeling and Postpartum Breast Cancer

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer.
Watch the video.
Goddard ET, Fischer J, Schedin P.
J Vis Exp. 2016 Dec 26;(118). doi: 10.3791/54903.
PMID: 28060292

The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis.
Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P.
Cancer Discov. 2016 Dec 14. doi: 10.1158/2159-8290.CD-16-0822. [Epub ahead of print]
PMID: 27974414

COX-2 modulates mammary tumor progression in response to collagen density.
Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P.
Breast Cancer Res. 2016 Mar 22;18(1):35. doi: 10.1186/s13058-016-0695-3.
PMID: 27000374

Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.
Fornetti J, Flanders KC, Henson PM, Tan AC, Borges VF, Schedin P.
Cell Death Differ. 2016 Feb;23(2):185-96. doi: 10.1038/cdd.2015.82.
PMID: 26113040

Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women.
Collins LC, Gelber S, Marotti JD, White S, Ruddy K, Brachtel EF, Schapira L, Come SE, Borges VF, Schedin P, Warner E, Wensley T, Tamimi RM, Winer EP, Partridge AH.
Oncologist. 2015 Jul;20(7):713-8. doi: 10.1634/theoncologist.2014-0412.
PMID: 26025931 

Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression.
Martinson HA, Jindal S, Durand-Rougely C, Borges VF, Schedin P.
Int J Cancer. 2015 Apr 15;136(8):1803-13. doi: 10.1002/ijc.29181.
PMID: 25187059

Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium.
Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB.
J Natl Cancer Inst. 2014 Sep 15;106(10). pii: dju237. doi: 10.1093/jnci/dju237.
PMID: 25224496

Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer.
Lyons TR, Borges VF, Betts CB, Guo Q, Kapoor P, Martinson HA, Jindal S, Schedin P.
J Clin Invest. 2014 Sep;124(9):3901-12. doi: 10.1172/JCI73777.
PMID: 25133426

Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling.
Jindal S, Gao D, Bell P, Albrektsen G, Edgerton SM, Ambrosone CB, Thor AD, Borges VF, Schedin P.
Breast Cancer Res. 2014 Mar 28;16(2):R31. doi: 10.1186/bcr3633.
PMID: 24678808 

Collagen architecture in pregnancy-induced protection from breast cancer.
Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P.
J Cell Sci. 2013 Sep 15;126(Pt 18):4108-10. doi: 10.1242/jcs.121590.
PMID: 23843613

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.
O'Brien J, Martinson H, Durand-Rougely C, Schedin P.
Development. 2012 Jan;139(2):269-75. doi: 10.1242/dev.071696.
PMID: 22129827 

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland.
O'Brien J, Hansen K, Barkan D, Green J, Schedin P, O'Brien J, Hansen K, Barkan D, Green J, Schedin P.
Int J Dev Biol. 2011;55(7-9):745-55. doi: 10.1387/ijdb.113379jo.
PMID: 22161831

Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species.
O'Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Man YG, Borges V, Schedin P.
Am J Pathol. 2010 Mar;176(3):1241-55. doi: 10.2353/ajpath.2010.090735.
PMID: 20110414

Advances in ECM Proteomics & ECM Biology

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.
Bruno RD, Fleming JM, George AL, Boulanger CA, Schedin P, Smith GH.
Sci Rep. 2017 Jan 10;7:40196. doi: 10.1038/srep40196.
PMID: 28071703

Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments.
Goddard ET, Hill RC, Barrett A, Betts C, Guo Q, Maller O, Borges VF, Hansen KC, Schedin P.
Int J Biochem Cell Biol. 2016 Dec;81(Pt A):223-232. doi: 10.1016/j.biocel.2016.10.014.
PMID: 27771439

Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis.
O'Brien JH, Vanderlinden LA, Schedin PJ, Hansen KC.
J Proteome Res. 2012 Oct 5;11(10):4894-905. doi: 10.1021/pr3003744.
PMID: 22897585

Extracellular matrix composition reveals complex and dynamic stromal-epithelial interactions in the mammary gland.
Maller O, Martinson H, Schedin P.
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):301-18. doi: 10.1007/s10911-010-9189-6. Review.
PMID: 20811805

Isolation of mammary-specific extracellular matrix to assess acute cell-ECM interactions in 3D culture.
O'Brien J, Fornetti J, Schedin P.
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):353-64. doi: 10.1007/s10911-010-9185-x.
PMID: 20680416

DCIS Progression

Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype.
Wang Y, Jindal S, Martel M, Wu Y, Schedin P, Troxell M.
Hum Pathol. 2016 Sep;55:126-34. doi: 10.1016/j.humpath.2016.05.003.
PMID: 27195907

Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses.
Ruszczyk M, Zirpoli G, Kumar S, Bandera EV, Bovbjerg DH, Jandorf L, Khoury T, Hwang H, Ciupak G, Pawlish K, Schedin P, Masso-Welch P, Ambrosone CB, Hong CC.
Cancer Causes Control. 2016 Feb;27(2):183-98. doi: 10.1007/s10552-015-0696-z.
PMID: 26621543

Physiological COX-2 expression in breast epithelium associates with COX-2 levels in ductal carcinoma in situ and invasive breast cancer in young women.
Fornetti J, Jindal S, Middleton KA, Borges VF, Schedin P.
Am J Pathol. 2014 Apr;184(4):1219-29. doi: 10.1016/j.ajpath.2013.12.026.
PMID: 24518566

Obesity and Breast Cancer

Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer.
Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS.
Cancer Res. 2012 Dec 15;72(24):6490-501. doi: 10.1158/0008-5472.CAN-12-1653.
PMID: 23222299

Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats.
Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS.
Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1634-42. doi: 10.1152/ajpregu.00219.2010.
PMID: 20926768



Commentaries and Reviews

Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox.
Guo Q, Betts C, Pennock N, Mitchell E, Schedin P.
J Clin Med. 2017 Jan 13;6(1). pii: E10. doi: 10.3390/jcm6010010. Review.
PMID: 28098775

Tumor mechanics and metabolic dysfunction.
Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM.
Free Radic Biol Med. 2015 Feb;79:269-80. doi: 10.1016/j.freeradbiomed.2014.11.020. Review.
PMID: 25532934 

Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.
Fornetti J, Martinson HA, Betts CB, Lyons TR, Jindal S, Guo Q, Coussens LM, Borges VF, Schedin P.
J Mammary Gland Biol Neoplasia. 2014 Jul;19(2):213-28. doi: 10.1007/s10911-014-9322-z. Review.
PMID: 24952477

Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention.
Martinson HA, Lyons TR, Giles ED, Borges VF, Schedin P.
Exp Cell Res. 2013 Jul 1;319(11):1671-8. doi: 10.1016/j.yexcr.2013.04.018. Review.
PMID: 23664839

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.
Callihan EB, Gao D, Jindal S, Lyons TR, Manthey E, Edgerton S, Urquhart A, Schedin P, Borges VF.
Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x.
PMID: 23430224

Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.
Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME.
J Natl Cancer Inst. 2013 Feb 6;105(3):166-74. doi: 10.1093/jnci/djs505. Review.
PMID: 23264680 

Pregnancy-associated breast cancer: an entity needing refinement of the definition.
Borges VF, Schedin PJ.
Cancer. 2012 Jul 1;118(13):3226-8. doi: 10.1002/cncr.26643. No abstract available.
PMID: 22086839 

Emerging targets for the prevention of pregnancy-associated breast cancer.
Fornetti J, Martinson H, Borges V, Schedin P.
Cell Cycle. 2012 Feb 15;11(4):639-40. doi: 10.4161/cc.11.4.19358. No abstract available.
PMID: 22374663

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.
Schedin P, Keely PJ.
Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a003228. doi: 10.1101/cshperspect.a003228. Review.
PMID: 20980442