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Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis.
Bartlett AQ, Pennock ND, Klug A, Schedin P: Cancers (Basel) 2021, 13.

The definition of pregnancy-associated breast cancer is outdated and should no longer be used.
Amant F, Lefrere H, Borges VF, Cardonick E, Lambertini M, Loibl S, Peccatori F, Partridge A, Schedin P: Lancet Oncol 2021, 22:753-4.

Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer.
Bernhardt SM, Borges VF, Schedin P: Cancer Prev Res (Phila) 2021, 14:825-38.

Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes.
Jindal S, Pennock ND, Sun D, Horton W, Ozaki MK, Narasimhan J, Bartlett AQ, Weinmann S, Goss PE, Borges VF, Xia Z, Schedin P: Nat Commun 2021, 12:6341.
*Altmetric Score of 32, top 93% of all research outputs

Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data.
Sun D, Guan X, Moran AE, Wu LY, Qian DZ, Schedin P, Dai MS, Danilov AV, Alumkal JJ, Adey AC, Spellman PT, Xia Z: Nat Biotechnol 2021. 

*Altmetric Score of 75, top 96% of all research output.

Molecular and clinical characterization of postpartum-associated breast cancer in the Carolina Breast Cancer Study Phase I-III, 1993-2013.
Vohra SN, Walens A, Hamilton AM, Sherman ME, Schedin P, Nichols HB, Reeder-Hayes KE, Olshan AF, Love MI, Troester MA: Cancer Epidemiol Biomarkers Prev 2021.

Pregnancy and weaning regulate human maternal liver size and function.
Bartlett, AQ, Vesco KK, Purnell JQ, Francisco M, Goddard E, Guan X, DeBarber A, Leo MC, Baetscher E, Rooney W, Naugler W, Guimaraes AR, Catalano P, Xia Z, Schedin P: Proc Natl Acad Sci U S A 2021, 118.

Mammary collagen is under reproductive control with implications for breast cancer.
Guo Q, Sun D, Barrett AS, Jindal S, Pennock ND, Conklin MW, Xia Z, Mitchell E, Samatham R, Mirza N, Jacques S, Weinmann S, Borges VF, Hansen KC, Schedin PJ: Matrix Biol 2021.

NHERF1 is required for localization of PMCA2 and suppression of early involution in the female lactating mammary gland.
Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ.
Endocrinology. 2019 May 14. pii: en.2019-00230. doi: 10.1210/en.2019-00230. [Epub ahead of print]
PMID: 31087002

Association between postpartum breast cancer diagnosis and metastasis and the clinical features underlying risk.
Goddard ET, Bassale S, Schedin T, Jindal S, Johnston J, Cabral E, Latour E, Lyons TR, Mori M, Schedin PJ, Borges VF.
JAMA Netw Open. 2019 Jan 4;2(1):e186997. doi: 10.1001/jamanetworkopen.2018.6997.
PMID: 30646210

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
Pennock ND, Martinson HA, Guo Q, Betts CB, Jindal S, Tsujikawa T, Coussens LM, Borges VF, Schedin P.
J Immunother Cancer. 2018 Oct 1;6(1):98. doi: 10.1186/s40425-018-0406-y.
PMID: 30285905

Semaphorin 7A promotes macrophage-mediated lymphatic remodeling during postpartum mammary gland involution and in breast cancer.
Elder AM, Tamburini BAJ, Crump LS, Black SA, Wessells VM, Schedin PJ, Borges VF, Lyons TR.
Cancer Res. 2018 Nov 15;78(22):6473-6485. doi: 10.1158/0008-5472.CAN-18-1642. Epub 2018 Sep 25.
PMID: 30254150

Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.
Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P.
Breast Cancer Res. 2018 Jun 14;20(1):50. doi: 10.1186/s13058-018-0974-2.
PMID: 29898754

Mucosal immunity in the female murine mammary gland.
Betts CB, Pennock ND, Caruso BP, Ruffell B, Borges VF, Schedin P.
J Immunol. 2018 Jul 15;201(2):734-746. doi: 10.4049/jimmunol.1800023. Epub 2018 Jun 8.
PMID: 29884705

Physiologically activated mammary fibroblasts promote postpartum mammary cancer.
Guo Q, Minnier J, Burchard J, Chiotti K, Spellman P, Schedin P.
JCI Insight. 2017 Mar 23;2(6):e89206. doi: 10.1172/jci.insight.89206.
PMID: 28352652

Metformin accumulation correlates with organic cation transporter 2 protein expression and predicts mammary tumor regression in vivo.
Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS.
Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. doi: 10.1158/1940-6207.CAPR-16-0211-T. Epub 2017 Feb 2.
PMID: 28154203

A portal vein injection model to study liver metastasis of breast cancer.
See a video presentation of this project, featuring Schedin Lab researchers.
Goddard ET, Fischer J, Schedin P.
J Vis Exp. 2016 Dec 26;(118). doi: 10.3791/54903.
PMID: 28060292

The rodent liver undergoes weaning-induced involution and supports breast cancer metastasis.
Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P.
Cancer Discov. 2016 Dec 14. doi: 10.1158/2159-8290.CD-16-0822. [Epub ahead of print]
PMID: 27974414

COX-2 modulates mammary tumor progression in response to collagen density.
Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P.
Breast Cancer Res. 2016 Mar 22;18(1):35. doi: 10.1186/s13058-016-0695-3.
PMID: 27000374

Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.
Fornetti J, Flanders KC, Henson PM, Tan AC, Borges VF, Schedin P.
Cell Death Differ. 2016 Feb;23(2):185-96. doi: 10.1038/cdd.2015.82.
PMID: 26113040

Molecular phenotype of breast cancer according to time since last pregnancy in a large cohort of young women.
Collins LC, Gelber S, Marotti JD, White S, Ruddy K, Brachtel EF, Schapira L, Come SE, Borges VF, Schedin P, Warner E, Wensley T, Tamimi RM, Winer EP, Partridge AH.
Oncologist. 2015 Jul;20(7):713-8. doi: 10.1634/theoncologist.2014-0412.
PMID: 26025931 

Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression.
Martinson HA, Jindal S, Durand-Rougely C, Borges VF, Schedin P.
Int J Cancer. 2015 Apr 15;136(8):1803-13. doi: 10.1002/ijc.29181.
PMID: 25187059

Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium.
Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB.
J Natl Cancer Inst. 2014 Sep 15;106(10). pii: dju237. doi: 10.1093/jnci/dju237.
PMID: 25224496

Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer.
Lyons TR, Borges VF, Betts CB, Guo Q, Kapoor P, Martinson HA, Jindal S, Schedin P.
J Clin Invest. 2014 Sep;124(9):3901-12. doi: 10.1172/JCI73777.
PMID: 25133426

Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling.
Jindal S, Gao D, Bell P, Albrektsen G, Edgerton SM, Ambrosone CB, Thor AD, Borges VF, Schedin P.
Breast Cancer Res. 2014 Mar 28;16(2):R31. doi: 10.1186/bcr3633.
PMID: 24678808 

Collagen architecture in pregnancy-induced protection from breast cancer.
Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P.
J Cell Sci. 2013 Sep 15;126(Pt 18):4108-10. doi: 10.1242/jcs.121590.
PMID: 23843613

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.
O'Brien J, Martinson H, Durand-Rougely C, Schedin P.
Development. 2012 Jan;139(2):269-75. doi: 10.1242/dev.071696.
PMID: 22129827 

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
Lyons TR, O'Brien J, Borges VF, Conklin MW, Keely PJ, Eliceiri KW, Marusyk A, Tan AC, Schedin P.
Nat Med. 2011 Aug 7;17(9):1109-15. doi: 10.1038/nm.2416.
PMID: 21822285 

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland.
O'Brien J, Hansen K, Barkan D, Green J, Schedin P, O'Brien J, Hansen K, Barkan D, Green J, Schedin P.
Int J Dev Biol. 2011;55(7-9):745-55. doi: 10.1387/ijdb.113379jo.
PMID: 22161831

Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species.
O'Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Man YG, Borges V, Schedin P.
Am J Pathol. 2010 Mar;176(3):1241-55. doi: 10.2353/ajpath.2010.090735.
PMID: 20110414

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.
Bruno RD, Fleming JM, George AL, Boulanger CA, Schedin P, Smith GH.
Sci Rep. 2017 Jan 10;7:40196. doi: 10.1038/srep40196.
PMID: 28071703

Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments.
Goddard ET, Hill RC, Barrett A, Betts C, Guo Q, Maller O, Borges VF, Hansen KC, Schedin P.
Int J Biochem Cell Biol. 2016 Dec;81(Pt A):223-232. doi: 10.1016/j.biocel.2016.10.014.
PMID: 27771439

Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis.
O'Brien JH, Vanderlinden LA, Schedin PJ, Hansen KC.
J Proteome Res. 2012 Oct 5;11(10):4894-905. doi: 10.1021/pr3003744.
PMID: 22897585

Extracellular matrix composition reveals complex and dynamic stromal-epithelial interactions in the mammary gland.
Maller O, Martinson H, Schedin P.
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):301-18. doi: 10.1007/s10911-010-9189-6. Review.
PMID: 20811805

Isolation of mammary-specific extracellular matrix to assess acute cell-ECM interactions in 3D culture.
O'Brien J, Fornetti J, Schedin P.
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):353-64. doi: 10.1007/s10911-010-9185-x.
PMID: 20680416

A method for quantification of calponin expression in myoepithelial cells in immunohistochemical images of ductal carcinoma in situ.
Gray E, Mitchell E, Jindal S, Schedin P, Chang YH.
Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:796-799. doi: 10.1109/ISBI.2018.8363692. Epub 2018 May 24.
PMID: 30364524

Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype.
Wang Y, Jindal S, Martel M, Wu Y, Schedin P, Troxell M.
Hum Pathol. 2016 Sep;55:126-34. doi: 10.1016/j.humpath.2016.05.003.
PMID: 27195907

Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses.
Ruszczyk M, Zirpoli G, Kumar S, Bandera EV, Bovbjerg DH, Jandorf L, Khoury T, Hwang H, Ciupak G, Pawlish K, Schedin P, Masso-Welch P, Ambrosone CB, Hong CC.
Cancer Causes Control. 2016 Feb;27(2):183-98. doi: 10.1007/s10552-015-0696-z.
PMID: 26621543

Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.
Russell TD, Jindal S, Agunbiade S, Gao D, Troxell M, Borges VF, Schedin P.
Am J Pathol. 2015 Nov;185(11):3076-89. doi: 10.1016/j.ajpath.2015.07.004.
PMID: 26343330

Physiological COX-2 expression in breast epithelium associates with COX-2 levels in ductal carcinoma in situ and invasive breast cancer in young women.
Fornetti J, Jindal S, Middleton KA, Borges VF, Schedin P.
Am J Pathol. 2014 Apr;184(4):1219-29. doi: 10.1016/j.ajpath.2013.12.026.
PMID: 24518566

The androgen receptor supports tumor progression after the loss of ovarian function in a preclinical model of obesity and breast cancer.
Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM.
Horm Cancer. 2017 Dec;8(5-6):269-285. doi: 10.1007/s12672-017-0302-9. Epub 2017 Jul 24.
PMID: 28741260

Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer.
Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS.
Cancer Res. 2012 Dec 15;72(24):6490-501. doi: 10.1158/0008-5472.CAN-12-1653.
PMID: 23222299

Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats.
Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS.
Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1634-42. doi: 10.1152/ajpregu.00219.2010.
PMID: 20926768

A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats.
MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman MR, Shroyer KR, Schedin PJ.
Obesity (Silver Spring). 2010 Apr;18(4):696-703. doi: 10.1038/oby.2009.307.
PMID: 19798068 

Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox.
Guo Q, Betts C, Pennock N, Mitchell E, Schedin P.
J Clin Med. 2017 Jan 13;6(1). pii: E10. doi: 10.3390/jcm6010010. Review.
PMID: 28098775

Tumor mechanics and metabolic dysfunction.
Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM.
Free Radic Biol Med. 2015 Feb;79:269-80. doi: 10.1016/j.freeradbiomed.2014.11.020. Review.
PMID: 25532934 

Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.
Fornetti J, Martinson HA, Betts CB, Lyons TR, Jindal S, Guo Q, Coussens LM, Borges VF, Schedin P.
J Mammary Gland Biol Neoplasia. 2014 Jul;19(2):213-28. doi: 10.1007/s10911-014-9322-z. Review.
PMID: 24952477

Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention.
Martinson HA, Lyons TR, Giles ED, Borges VF, Schedin P.
Exp Cell Res. 2013 Jul 1;319(11):1671-8. doi: 10.1016/j.yexcr.2013.04.018. Review.
PMID: 23664839

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.
Callihan EB, Gao D, Jindal S, Lyons TR, Manthey E, Edgerton S, Urquhart A, Schedin P, Borges VF.
Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x.
PMID: 23430224

Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.
Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME.
J Natl Cancer Inst. 2013 Feb 6;105(3):166-74. doi: 10.1093/jnci/djs505. Review.
PMID: 23264680 

Pregnancy-associated breast cancer: an entity needing refinement of the definition.
Borges VF, Schedin PJ.
Cancer. 2012 Jul 1;118(13):3226-8. doi: 10.1002/cncr.26643. No abstract available.
PMID: 22086839 

Emerging targets for the prevention of pregnancy-associated breast cancer.
Fornetti J, Martinson H, Borges V, Schedin P.
Cell Cycle. 2012 Feb 15;11(4):639-40. doi: 10.4161/cc.11.4.19358. No abstract available.
PMID: 22374663

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.
Schedin P, Keely PJ.
Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a003228. doi: 10.1101/cshperspect.a003228. Review.
PMID: 20980442