Publications

Selected publications

Fibroblasts as Modulators of Local and Systemic Cancer Metabolism.
Sanford-Crane H, Abrego J, Sherman MH.
Cancers (Basel). 2019 May 3;11(5). pii: E619. doi: 10.3390/cancers11050619. Review.
PMID: 31058816

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression.
Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH.
Cancer Discovery, in press.

Stellate Cells in Tissue Repair, Inflammation, and Cancer.
Sherman MH.
Annu Rev Cell Dev Biol. 2018 Jul 20. doi: 10.1146/annurev-cellbio-100617-062855.
PMID: 30028641.

Stromal cues regulate the pancreatic cancer epigenome and metabolome.
Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM.
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134. doi: 10.1073/pnas.1620164114.
PMID: 28096419.

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.
Nature. 2016 Aug 25;536(7617):479-83.
PMID: 27509858.

Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer.
Hah N, Sherman MH, Yu RT, Downes M, Evans RM.
Cold Spring Harb Symp Quant Biol. 2016 Jan 22. pii: 027185. [Epub ahead of print].
PMID: 26801159.

BRD4 is a novel therapeutic target for liver fibrosis.
Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM.
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15713-8. doi: 10.1073/pnas.1522163112. Epub 2015 Dec 7.
PMID: 26644586 .

Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer.
Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW.
Mol Cancer Res. 2015 Nov;13(11):1509-19. doi: 10.1158/1541-7786.MCR-15-0204. Epub 2015 Jul 29.
PMID: 26224368.

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.
Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM.
Cell. 2014 Sep 25;159(1):80-93. doi: 10.1016/j.cell.2014.08.007.
PMID: 25259922.

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response.
Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM.
Cell. 2013 Apr 25;153(3):601-13. doi: 10.1016/j.cell.2013.03.028.
PMID: 23622244.