About us

The Sherman Lab aims to understand the transcriptional and epigenetic gene-regulatory networks that underlie tumor-stroma interactions in pancreatic cancer, and to target these networks for therapeutic benefit. Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function, and how these stromal mechanisms affect cell fate and function in the pancreatic epithelium with respect to gene expression, metabolism, and growth. 

Our laboratory uses a multidisciplinary approach to investigate the mechanistic underpinnings of the pancreatic tumor microenvironment, including mouse models of pancreatic cancer, three-dimensional cell culture systems such as patient-derived organoids, and diverse molecular- and cell-biological techniques focused on gene regulation.

Work in the Sherman Lab is generously funded by

  • American Cancer Society
  • DOD PRCRP
  • V Foundation
  • National Cancer Institute
  • Brenden-Colson Center for Pancreatic Care
  • Medical Research Foundation
  • Cancer Early Detection and Research Center
  • Hirshberg Foundation
  • Forbeck Foundation

Our lab is growing

Sherman lab is recruiting. See our Contact Us page for more details.