Biomedical Research of Addiction, Imaging and Neuroscience (BRAIN) Lab

Dr. Kohno sits next to a computer screen showing rows of brain images with red coloring to indicate regions of activation.
Milky Kohno, Ph.D., is an associate professor of psychiatry at OHSU and a research scientist at the Portland VA Medical Center. She leads the OHSU BRAIN Lab.

Bridging basic science to treatment for addiction

At OHSU’s BRAIN Lab, led by Milky Kohno, Ph.D., we are improving treatment for methamphetamine use disorder and alcohol use disorder. 

Our research uses advanced neuroimaging to understand how drug and alcohol use affect brain function. We test how various treatments decrease inflammation, improve brain function and reduce drug use.

We work closely with other psychiatry labs at OHSU and the Portland VA Medical Center to understand substance use disorders by integrating neurobiology, immunology and endocrinology. 

On this page you can:  

Research projects

The BRAIN Lab studies the brain at the molecular and systems levels, using advanced neuroimaging. We test the effectiveness and mechanisms of medications for the treatment of addiction. Dr. Kohno is the principal investigator for two ongoing clinical trials.

ABSTAIN: Sex differences in trauma, inflammation and brain function

We are studying how trauma and inflammation may affect brain function in people with alcohol use disorder. We hope to find biological markers (biomarkers) that show how well Naltrexone works. Naltrexone is a medication commonly used to treat alcohol use disorder.

We also hope to find any differences in how well Naltrexone works between men and women. This could help care providers create more personalized treatment plans in the future.

Join the ABSTAIN study

Call 503-721-7964 to participate in our ABSTAIN study. You might be eligible if you are:

  • A U.S. veteran
  • Not using substances except for alcohol, nicotine or marijuana
  • Right-handed
  • 18-60 years old
  • Comfortable with a 1-hour MRI scan  

Clinical trial of IBUDILAST for methamphetamine use disorder

We are researching how neuroinflammation affects brain function in people with methamphetamine use disorder.

In this clinical trial, we use the medication Ibudiblast to reduce inflammation. We want to understand how a reduction in brain inflammation improves brain function in dopamine-related neural networks. This study may lead to a treatment that will reduce cravings and use of methamphetamines by improving neural network function.  

Join the IBUDILAST clinical trial

Learn how to participate in our IBUDILAST study. Participants are paid up to $500.

You might be eligible if you:

  • Are 18-60 years old
  • Regularly use methamphetamines (within the last four weeks)
  • Have no foreign metal objects in your body, except from medical procedures
  • Have not been part of an investigational drug study in the past three months

Publications

Find more publications by Dr. Milky Kohno on PubMed. 

Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment

Molecular Psychiatry 2022

Kohno M, Dennis L, McCready H, Hoffman W.

Probabilistic reversal learning deficits in patients with methamphetamine use disorder—A longitudinal pilot study

Frontiers in Psychiatry 2020

Pilhatsch M, Pooseh S, Junke A, Kohno M, Petzold J, Sauer C, Smolka M.

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

Pharmacology Biochemistry and Behavior 2019

Kohno M, Link J, Dennis L, McCready H, Huckans M, Hoffman W, Loftis J.

Effects of Naltrexone on Large-Scale Network Interactions in Methamphetamine Use Disorder

Frontiers in Psychiatry 2019

Kohno M, Morales A, Dennis L, McCready H, Hoffman W, Korthuis T.

The relationship between interleukin-6 and functional connectivity in methamphetamine users

Neuroscience Letters 2018

Kohno M, Loftis J, Huckans M, Dennis L, McCready H, Hoffman W.

Executive control and striatal resting-state network interact with risk factors to influence treatment outcomes in alcohol-use disorder

Frontiers in Psychiatry 2017

Kohno M, Dennis L, McCready H, Hoffman W.

Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users

Molecular Psychiatry 2016

Kohno M, Okita K, Morales A, Robertson C, Dean A, Ghahremani D, Sabb F, Rawson R, Mandelkern M, Bilder R, London E. 

People

The BRAIN Lab is led by Milky Kohno, Ph.D., a neuroscientist and expert on the molecular mechanisms behind brain dysfunction in addiction. Dr. Kohno has published extensively on neurological biomarkers to target in the treatment of substance use disorders. 

    • Appointments and titles

      • Associate Professor of Psychiatry, School of Medicine
      • Research Professor of Medical Physics Graduate Program, School of Medicine
    • Areas of interest

      • Addiction
      • Neuroimaging: fMRI, PET
      • Dopamine Dysregulation
      • Pharmacotherapy
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Effects of methamphetamine on cognition and decision-making

Laura Dennis, B.S., research coordinator and data analyst

A photo of Laura Dennis with a small dog in her lap.

Laura Dennis holds a B.S. in bioengineering from Oregon State University and works at several labs at OHSU and the Portland VA. She has worked in the BRAIN Lab for 10 years, using multi-modal neuroimaging techniques to study the effects of methamphetamine and alcohol use disorders on the brain. Outside the lab, she enjoys Timbers games, travel and cuddling with her mini dachshund.

Jazryn Nagum, B.A., senior research associate

Jazryn Nagum, B.A., senior research associate

Jazryn Nagum holds a B.A. in psychology with a minor in neuroscience from the University of Portland. Her research interests include substance use and the relationship between pain and cognitive function.

Juyoung (Gloria) Choi, B.S., research assistant

Gloria Choi

Juyoung (Gloria) Choi holds a B.S. nursing and is registered nurse. Her research interests include clinical improvement, neurocritical care and patient safety and quality care. She likes staying active, trying new experiences, reading and spending time with family and friends.

Matthew Cordova, B.A., research assistant

Matthew Cordova, B.A., student research assistant

Matthew Cordova is a student working on a B.A. in psychology and a B.S. in cell, molecular and biomedical sciences at the University of Portland. His research interests include environmental factors that affect mental health disorders and biological mechanisms like sleep and cognitive function. He enjoys spending time outdoors and running. Cordova is part of the University of Portland's cross-country team.

Richard Fuentes, B.A., research assistant

Richard Fuentez

Richard Fuentes holds a B.A. in interdisciplinary studies with an emphasis in biology, communications and psychology from San Diego State University. He works as a mental health counselor on a child & adolescent psychiatric unit, while serving on the board of directors for Students for Sensible Drug Policy. His research interests include harm reduction, altered states of consciousness, and emerging addiction treatments.

Kylie Koney, B.A., M.D. candidate

Kylie Koney

Kylie Koney holds a B.A. in biology and a minor in psychology from the University of Portland. She is currently a second-year medical student at OHSU and is interested in the fields of child & adolescent psychiatry as well as addiction medicine. Outside of school and the lab, Kylie enjoys reading, hiking, and going to concerts.

Wesley Ng, B.S., research assistant

Wesley Ng, B.S., student research assistant

Wesley Ng holds a B.S. in biology with a minor in neuroscience from the University of Portland. In the BRAIN Lab, he works on projects studying sex-based differences and neuroinflammation related to substance use. He is interested in clinical medicine and understanding addiction pathways and treatments. Outside the lab, Ng enjoys playing video games, hiking and trying new food spots.

Esteban Rigales, B.A., research assistant

Esteban Rigales, B.A., research assistant

Esteban Rigales holds a B.A. in psychology with a minor in neuroscience from the University of Portland. He is interested in the relationship between substance use and mental illness, and the neurobiology of personality disorders. Outside of the lab, Rigales enjoys fishing, camping and cooking.

Rén Rosz, M.D., research assistant

Rén Rosz

Rén Rosz currently holds their M.D. from UAG and is pursuing an M.P.H. at the OHSU-PSU School of Public Health. They are going into Emergency Medicine and are interested in research that works to link street to clinics and addresses the Social Determinants of Health. Rén is an avid foodie, who likes spending time on patios and porches, making art, and playing music.

Melissa Steinert, B.S., research assistant

Melissa Steinert, B.S., student research assistant

Melissa Steinert holds a B.S. in biology from the University of Portland. Her interests include neuroscience and nuclear medicine. Outside the lab, she enjoys drawing, catching crabs, and watching bad TV shows.

Maja Strusinska-Thayer, B.S., research assistant

Maja Strusinska-Thayer, B.S., volunteer

Maja Strusinska-Thayer holds a B.S. in biology with a minor in neuroscience from the University of Portland. She is a clinical research assistant for OHSU's Center for Policy and Research in Emergency Medicine, and a volunteer in the BRAIN Lab. 

Sophia Swain, B.S., B.A., research assistant

Sophia Swain, B.S., B.A., research assistant

Sophia Swain holds a B.A. in psychology and a B.S. in biology with a minor in neuroscience, both from the University of Portland. Her research interests include substance use and understanding its role in daily functioning. Outside of the lab, Swain loves exploring the Pacific Northwest and watching nature documentaries.

Nine members of the OHSU BRAIN Lab pose together in front of the Portland VA, building 1.
The OHSU BRAIN Lab is a close-knit team that includes experts in neuroscience; research assistants; and students.

Contact us

Volunteer for research

Join one of our studies:

  • ABSTAIN, a study of sex differences in alcohol use disorders 
  • IBUDILAST, a clinical trial for a treatment for meth use disorder 

Call 503-721-7964 to learn more.