Biomedical Research of Addiction, Imaging and Neuroscience (BRAIN) Lab
Bridging basic science to treatment for addiction
At OHSU’s BRAIN Lab, led by Milky Kohno, Ph.D., we are improving treatment for methamphetamine use disorder and alcohol use disorder.
Our research uses advanced neuroimaging to understand how drug and alcohol use affect brain function. We test how various treatments decrease inflammation, improve brain function and reduce drug use.
We work closely with other psychiatry labs at OHSU and the Portland VA Medical Center to understand substance use disorders by integrating neurobiology, immunology and endocrinology.
On this page you can:
Research projects
The BRAIN Lab studies the brain at the molecular and systems levels, using advanced neuroimaging. We test the effectiveness and mechanisms of medications for the treatment of addiction. Dr. Kohno is the principal investigator for two ongoing clinical trials.
ABSTAIN: Sex differences in trauma, inflammation and brain function
We are studying how trauma and inflammation may affect brain function in people with alcohol use disorder. We hope to find biological markers (biomarkers) that show how well Naltrexone works. Naltrexone is a medication commonly used to treat alcohol use disorder.
We also hope to find any differences in how well Naltrexone works between men and women. This could help care providers create more personalized treatment plans in the future.
Join the ABSTAIN study
Call 503-721-7964 to participate in our ABSTAIN study. You might be eligible if you are:
- A U.S. veteran
- Not using substances except for alcohol, nicotine or marijuana
- Right-handed
- 18-60 years old
- Comfortable with a 1-hour MRI scan
Clinical trial of IBUDILAST for methamphetamine use disorder
We are researching how neuroinflammation affects brain function in people with methamphetamine use disorder.
In this clinical trial, we use the medication Ibudiblast to reduce inflammation. We want to understand how a reduction in brain inflammation improves brain function in dopamine-related neural networks. This study may lead to a treatment that will reduce cravings and use of methamphetamines by improving neural network function.
Join the IBUDILAST clinical trial
Learn how to participate in our IBUDILAST study. Participants are paid up to $500.
You might be eligible if you:
- Are 18-60 years old
- Regularly use methamphetamines (within the last four weeks)
- Have no foreign metal objects in your body, except from medical procedures
- Have not been part of an investigational drug study in the past three months
Publications
Find more publications by Dr. Milky Kohno on PubMed.
Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment
Molecular Psychiatry 2022
Kohno M, Dennis L, McCready H, Hoffman W.
Probabilistic reversal learning deficits in patients with methamphetamine use disorder—A longitudinal pilot study
Frontiers in Psychiatry 2020
Pilhatsch M, Pooseh S, Junke A, Kohno M, Petzold J, Sauer C, Smolka M.
Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
Pharmacology Biochemistry and Behavior 2019
Kohno M, Link J, Dennis L, McCready H, Huckans M, Hoffman W, Loftis J.
Effects of Naltrexone on Large-Scale Network Interactions in Methamphetamine Use Disorder
Frontiers in Psychiatry 2019
Kohno M, Morales A, Dennis L, McCready H, Hoffman W, Korthuis T.
The relationship between interleukin-6 and functional connectivity in methamphetamine users
Neuroscience Letters 2018
Kohno M, Loftis J, Huckans M, Dennis L, McCready H, Hoffman W.
Executive control and striatal resting-state network interact with risk factors to influence treatment outcomes in alcohol-use disorder
Frontiers in Psychiatry 2017
Kohno M, Dennis L, McCready H, Hoffman W.
Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users
Molecular Psychiatry 2016
Kohno M, Okita K, Morales A, Robertson C, Dean A, Ghahremani D, Sabb F, Rawson R, Mandelkern M, Bilder R, London E.
People
The BRAIN Lab is led by Milky Kohno, Ph.D., a neuroscientist and expert on the molecular mechanisms behind brain dysfunction in addiction. Dr. Kohno has published extensively on neurological biomarkers to target in the treatment of substance use disorders.
-
-
Appointments and titles
- Associate Professor of Psychiatry, School of Medicine
- Research Professor of Medical Physics Graduate Program, School of Medicine
-
Areas of interest
- Addiction
- Neuroimaging: fMRI, PET
- Dopamine Dysregulation
- Pharmacotherapy
-
-
-
Appointments and titles
- Professor of Behavioral Neuroscience, School of Medicine
-
Areas of interest
- Effects of methamphetamine on cognition and decision-making
-
Laura Dennis, B.S., research coordinator and data analyst
Laura Dennis holds a B.S. in bioengineering from Oregon State University and works at several labs at OHSU and the Portland VA. She has worked in the BRAIN Lab for 10 years, using multi-modal neuroimaging techniques to study the effects of methamphetamine and alcohol use disorders on the brain. Outside the lab, she enjoys Timbers games, travel and cuddling with her mini dachshund.
Jazryn Nagum, B.A., senior research associate
Jazryn Nagum holds a B.A. in psychology with a minor in neuroscience from the University of Portland. Her research interests include substance use and the relationship between pain and cognitive function.
Juyoung (Gloria) Choi, B.S., research assistant
Juyoung (Gloria) Choi holds a B.S. nursing and is registered nurse. Her research interests include clinical improvement, neurocritical care and patient safety and quality care. She likes staying active, trying new experiences, reading and spending time with family and friends.
Matthew Cordova, B.A., research assistant
Matthew Cordova is a student working on a B.A. in psychology and a B.S. in cell, molecular and biomedical sciences at the University of Portland. His research interests include environmental factors that affect mental health disorders and biological mechanisms like sleep and cognitive function. He enjoys spending time outdoors and running. Cordova is part of the University of Portland's cross-country team.
Richard Fuentes, B.A., research assistant
Richard Fuentes holds a B.A. in interdisciplinary studies with an emphasis in biology, communications and psychology from San Diego State University. He works as a mental health counselor on a child & adolescent psychiatric unit, while serving on the board of directors for Students for Sensible Drug Policy. His research interests include harm reduction, altered states of consciousness, and emerging addiction treatments.
Kylie Koney, B.A., M.D. candidate
Kylie Koney holds a B.A. in biology and a minor in psychology from the University of Portland. She is currently a second-year medical student at OHSU and is interested in the fields of child & adolescent psychiatry as well as addiction medicine. Outside of school and the lab, Kylie enjoys reading, hiking, and going to concerts.
Wesley Ng, B.S., research assistant
Wesley Ng holds a B.S. in biology with a minor in neuroscience from the University of Portland. In the BRAIN Lab, he works on projects studying sex-based differences and neuroinflammation related to substance use. He is interested in clinical medicine and understanding addiction pathways and treatments. Outside the lab, Ng enjoys playing video games, hiking and trying new food spots.
Esteban Rigales, B.A., research assistant
Esteban Rigales holds a B.A. in psychology with a minor in neuroscience from the University of Portland. He is interested in the relationship between substance use and mental illness, and the neurobiology of personality disorders. Outside of the lab, Rigales enjoys fishing, camping and cooking.
Rén Rosz, M.D., research assistant
Rén Rosz currently holds their M.D. from UAG and is pursuing an M.P.H. at the OHSU-PSU School of Public Health. They are going into Emergency Medicine and are interested in research that works to link street to clinics and addresses the Social Determinants of Health. Rén is an avid foodie, who likes spending time on patios and porches, making art, and playing music.
Melissa Steinert, B.S., research assistant
Melissa Steinert holds a B.S. in biology from the University of Portland. Her interests include neuroscience and nuclear medicine. Outside the lab, she enjoys drawing, catching crabs, and watching bad TV shows.
Maja Strusinska-Thayer, B.S., research assistant
Maja Strusinska-Thayer holds a B.S. in biology with a minor in neuroscience from the University of Portland. She is a clinical research assistant for OHSU's Center for Policy and Research in Emergency Medicine, and a volunteer in the BRAIN Lab.
Sophia Swain, B.S., B.A., research assistant
Sophia Swain holds a B.A. in psychology and a B.S. in biology with a minor in neuroscience, both from the University of Portland. Her research interests include substance use and understanding its role in daily functioning. Outside of the lab, Swain loves exploring the Pacific Northwest and watching nature documentaries.
Contact us
Volunteer for research
Join one of our studies:
- ABSTAIN, a study of sex differences in alcohol use disorders
- IBUDILAST, a clinical trial for a treatment for meth use disorder
Call 503-721-7964 to learn more.