Publications
Selected publications
Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system
Roberts CG, Franklin TG, Pruneda JN. Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system. EMBO J. 2023 Aug 9:e114318. doi: 10.15252/embj.2023114318. Epub ahead of print. PMID: 37555693.
Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing
Szczesna M, Huang Y, Lacoursiere R, Bonini F, Pol V, Koc F, Ward B, Geurink P, Pruneda J, Thurston T. Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-2986327. doi: 10.21203/rs.3.rs-2986327/v1. PMID: 37503018; PMCID: PMC10371091.
Bacterial mimicry of eukaryotic HECT ubiquitin ligation
Franklin TG, Brzovic PS, Pruneda JN. Bacterial mimicry of eukaryotic HECT ubiquitin ligation. bioRxiv [Preprint]. 2023 Jun 5:2023.06.05.543783. doi: 10.1101/2023.06.05.543783. PMID: 37333152; PMCID: PMC10274628.
Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays
Pan X, Alvarez AN, Ma M, Lu S, Crawford MW, Briere LC, Kanca O, Yamamoto S, Sweetser DA, Wilson JL, Napier RJ, Pruneda JN, Bellen HJ. Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. medRxiv [Preprint]. 2023 Jul 23:2023.07.17.23292782. doi: 10.1101/2023.07.17.23292782. PMID: 37502976; PMCID: PMC10371176.
Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA
Warren GD, Kitao T, Franklin TG, Nguyen JV, Geurink PP, Kubori T, Nagai H, Pruneda JN. Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA. Mol Cell. 2023 Jan 5;83(1):105-120.e5. doi: 10.1016/j.molcel.2022.11.022. Epub 2022 Dec 19. PMID: 36538933; PMCID: PMC9825671.
A High-Throughput Assay for Monitoring Ubiquitination in Real Time
Franklin TG, Pruneda JN. A High-Throughput Assay for Monitoring Ubiquitination in Real Time. Front Chem. 2019 Dec 4;7:816. doi: 10.3389/fchem.2019.00816. PMID: 31867306; PMCID: PMC6904270.