Publications

Selected publications

Dr. Jacobs has authored a book chapter as well as many journal articles and conference publications. View Peter Jacobs on Google Scholar or visit his ResearchGate profile, where you can download many of his publications.

2021

Nguyen TP, Jacobs PG, Castle JR, Wilson LM, Branigan D, Gabo V, Senf B, Guillot FH, El Youssef J, “Separating Insulin-Mediated and Non-Insulin-Mediated Glucose Uptake during Aerobic Exercise in People with Type 1 Diabetes”, American Journal of Physiology – Endocrinology and Metabolism, 320(3),  e425-e437, 2021. Doi: https//10.1152/ajpendo.00534.2021

Mosquera-Lopez C, Wan E, Shastry M, Folsom J, Leitschuh J, Condon J, Rajhbeharrysingh U, Hildebrand A, Cameron MH, Jacobs PG. Automated Detection of Real-World Falls: Modeled from People with Multiple Sclerosis, IEEE J of Biom Health Informatics, 1-10, in press 2021, https://10.1109/JBHI.2020.3041035.

2020

M Riddell, Z Li, RW Beck, R Gal, PG Jacobs, JR Castle, M Gillingham, Clements M, Patton SR, Dassau E, Doyle FJ, Martin CK, Calhoun P, Rickels MR. More time in glucose range during exercise days than sedentary days in adults living with type 1 diabetes, Diabetes Technology & Therapeutics, 23(5), 376-383 2020

Gillingham MB, Li Z, Beck RW, Calhoun P, Castle J, Clements M, Dassau E, Doyle III FJ, Gal RL, Jacobs PG, Patton SR, Rickels MR, Riddell M, Martin CK. Assessing Mealtime Macronutrient Content: Patient Perceptions versus Expert Analyses via a Novel Phone App, Diabetes Technology and Therapeutics, in press 2020.

Wilson LM, Jacobs PG, Ramsey KL, Resalat N, Reddy R, Branigan D, Leitschuh J, Gabo V, Guillot F, Senf B, El Youssef JE, Steineck IIK, Tyler NS, Castle JR. Dual-Hormone Closed-Loop System Using a Liquid Stable Glucagon Formulation Versus Insulin-Only Closed-Loop System Compared With a Predictive Low Glucose Suspend System: An Open-Label, Outpatient, Single-Center, Crossover, Randomized Controlled Trial, Diabetes Care in press 2020, https://doi.org/10.2337/dc19-2267.

Haidar A, Legault L, Raffray M, Gouchie-Provencher N, Jacobs PG, El Fathi A, Rutkowski J, Messier V, Rabassa-Lhoret R. Comparison between closed-loop insulin delivery system (the artificial pancreas) and sensor-augmented pump therapy: a randomised controlled crossover trial, Diabetes Technology and Therapeutics, in press 2020. https://doi.org/10.1089/dia.2020.0365.

Moser M, Riddell MC, Eckstein ML, Adolfsson P, Rabasa-Lhoret R, van den Boom L, Gillard P, Norgaard K, Oliver NS, Zaharieva DP, Battelino T, de Beaufort C, Bergenstal RM, Buckingham B, Cengiz E, Deep A, Heise T, Heller S, Kowalski AJ, Leelarathna L, Mathiew C, Stettler C, Tauschmann M, Thabit H, Wilmot EG, Sourij H, Smart CE, Jacobs PG, Bracken M, Mader JK. Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA), Pediatric Diabetes, 2020 in press. https://doi.org/10.1111/pedi.13105.

Moser M, Riddell MC, Eckstein ML, Adolfsson P, Rabasa-Lhoret R, van den Boom L, Gillard P, Norgaard K, Oliver NS, Zaharieva DP, Battelino T, de Beaufort C, Bergenstal RM, Buckingham B, Cengiz E, Deep A, Heise T, Heller S, Kowalski AJ, Leelarathna L, Mathiew C, Stettler C, Tauschmann M, Thabit H, Wilmot EG, Sourij H, Smart CE, Jacobs PG, Bracken M, Mader JK. Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA), Diabetologia, 2020 in press. https://doi.org/10.1007/s00125-020-05263-9

Guillot FH, Jacobs PG, Wilson LM, El Youssef JE, Gabo VB, Branigan DL, Tyler NS, Ramsey K, Riddell MC, Castle JR. Accuracy of the Dexcom G6 Glucose Sensor during Aerobic, Resistance, and Interval Exercise in Adults with Type 1 Diabetes, Biosensors 10(10), 138, 1-12. https://doi.org/10.3390/bios10100138.

Tyler N, Mosquera-Lopez CM, Wilson LM, Dodier RH, Branigan DL, Gabo VB, Guillot FH, Hilts WW, El Youssef JE, Castle JR, Jacobs PG. An artificial intelligence decision support system for the management of type 1 diabetes. Nature Metabolism, 2020 accepted and in press.

Jacobs PG, Tyler N, Vanderwerf, SM, Mosquera-Lopez C, Seidl T, Cargill R, Branigan D, Ramsey K, Morris K, Benware S, Ward WK, Castle J. Measuring glucose at the site of insulin delivery with a redox-mediated sensor, Biosensors and Bioelectronics, 2020 accepted and in press.

Mosquera-Lopez C, Dodier R, Tyler N, Wilson L, El Youssef J, Castle JR, Jacobs PG. Predicting and preventing nocturnal hypoglycemia in type 1 diabetes using big data analytics and decision theoretic analysis, Diabetes Technology and Therapeutics, accepted in press 2020. https://doi.org/10.1089/dia.2019.0458.

Khan T, Jacobs PG. Prediction of mild cognitive impairment using movement complexity. IEEE Journal of Biomedical Health Informatics, 2020 in press.

Palisaitis E, El Fathi A, Von Oettingen JE, Krishnamoorthy P, Kearney R, Jacobs PG, Rutkowski J, Legault L, Haidar A. The Efficacy of Basal Rate and Carbohydrate Ratio Learning Algorithm for Closed-Loop Insulin Delivery (Artificial Pancreas) in Youth with Type 1 Diabetes in a Diabetes Camp., Diabetes Technology & Therapeutics 22 (3), 185-194.

Jacobs PG, Reddy R, “Exercise, sleep, and type 1 diabetes”, In “Neurological Modulation of Sleep”, by Ronald Watson, March 2020 in press, Elsevier.

Tyler N, Jacobs PG. Artificial intelligence in decision support systems for type 1 diabetes. Sensors, 20(11), 1-26, 10.3390/s20113214. 

2019

Resalat N, Hilts W, El Youssef J, Tyler N, Castle JR, Jacobs PG. Adaptive control of an artificial pancreas using model identification, adaptive postprandial insulin delivery and heart rate and accelerometry as control inputs, Journal of Diabetes Science and Technology, in press 2019. doi.org/10.1177/1932296819870231

Reddy R, Resalat N, Wilson LM, Castle JR, El Youssef J, Jacobs PG, Prediction of hypoglycemia during aerobic exercise in adults with type 1 diabetes, Journal of Diabetes Science and Technology, in press, 2019. doi.org/10.1177/1932296818823792.

Resalat N, El Youssef J, Reddy R, Castle J, Jacobs PG, Adaptive tuning of basal and bolus insulin to reduce postprandial hypoglycemia in a hybrid artificial pancreas, Journal of Process Control, 2019 Aug 247-254, doi.org/10.1016/j.jprocont.2019.05.018

Resalat N, El Youssef J, Tyler N, Castle J, Jacobs PG, A statistical virtual patient population for the glucoregulatory system in type 1 diabetes with integrated exercise model, PLoS One, 2019 Jul; 14(7), 1-17. doi.org/10.1371/journal.pone.0217301.  

Wilson LM, Tyler N, Jacobs PG, Gabo V, Senf B, Reddy R, Castle JR, Patient input for design of a decision support smartphone application for type 1 diabetes. Journal of Diabetes Science and Technology, in press 2019. 

Mosquera-Lopez C, Leitschuh J, Condon J, Hagen CC, Rajhbeharrysingh U, Hanks C, Jacobs PG, Design and evaluation of a non-contact bed-mounted sensing device for automated in-home detection of obstructive sleep apnea: a pilot study, Biosensors, 2019 9(3) 1-14. doi.org/10.3390/bios9030090.

Wilson LM, Jacobs PG, Castle JR. Role of glucagon in automated insulin delivery.  Endocrinol. Metab. Clin. North Am, 49(1), 179-202, March 2020.

2018

Reddy R, Wittenberg A, Castle JR, El Youssef J, Winter-Stone K, Gillingham M, Jacobs PG, Effect of aerobic exercise on glycemic control in adults with type 1 diabetes. Canadian Journal of Diabetes, in press 2018. DOI: doi.org/10.1016/j.jcjd.2018.08.193

Jacobs PG, Hanaway P, Leitschuh J, Condon J, Rajhbeharrysingh U, Guidarelli C, Winters-Stone K, Design and evaluation of a portable smart-phone based peripheral neuropathy test platform. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018 in press.

Mosquera-Lopez C, Leitschuh J, Condon J, Hagen CC, Hanks C, Jacobs PG. In-home sleep apnea severity classification using contact-free load cells and an AdaBoosted decision tree algorithm. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, in press 2018.

Castle, JR, El Youssef J, Wilson L, Reddy R, Resalat N, Branigan D, Ramsey K, Leitschuh J, Rajhbeharrysingh U, Senf B, Sugerman S, Gabo V, Jacobs PG, Randomized outpatient trial of single and dual-hormone closed-loop systems that adapt to exercise using wearable sensors. Diabetes Care, 2018 in press Impact factor: 13.397

Reddy R, Pooni R, Zaharieva D, Sens B, El Youssef J, Dassau E, Doyle FJ, Clements MA, Rickels MR, Patton SR, Castle JE, Riddell MC, Jacobs PG, Accuracy of wrist-worn activity monitors during common daily physical activities and types of structured exercise. Journal of Medical Internet Research, in press 2018. Impact factor 4.671

    2017

    Brungart D, Schurman J, Konrad-Martin D, Watts K, Buckey J, Clavier O, Jacobs PG, Gordon S, Dille MF. Using tablet-based technology to deliver time-efficient ototoxicity monitoring", Int J of Audiology, 2017 Sep 12:1-9. DOI: dx.doi.org/10.1080/14992027.2017.1370138

    Winters-Stone KM, Horak F, Jacobs PG, Trubowitz P, Dieckmann NF, Stoyles S, Faithfull S, "Falls, functioning and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy", Journal of Clinical Oncology, 2017 in press, Impact factor 24.0.

    Reddy R, El Youssef J, Winters-Stone K, Branigan D, Leitschuh J, Castle J, Jacobs P, "The impact of exercise on sleep in adults with type 1 diabetes", Diabetes Obesity and Metabolism, in press 2017, Impact factor 6.7.
    Resalat R, El Youssef J, Reddy R, Jacobs PG, "Evaluation of model complexity in model predictive control within an exercise-enabled artificial pancreas" IFAC, 2017 in press.

      2016

      Jacobs PG, El Youssef J, Reddy R, Resalat N, Branigan D, Condon J, Preiser N, Ramsey K, Jones M, Edwards C, Kuehl K, Leitschuh J, Rajhbeharrysingh U, Castle J. Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy. Diabetes Obes Metab. 2016 Jun 23. doi: 10.1111/dom.12707. [Epub ahead of print] PubMed PMID: 27333970.

      Castle JR, Jacobs PG. Nonadjunctive Use of Continuous Glucose Monitoring for Diabetes Treatment Decisions. J Diabetes Sci Technol. 2016 Feb 15. pii: 1932296816631569. [Epub ahead of print] Review. PubMed PMID: 26880390.

      Austin J, Dodge, HH, Riley R, Jacobs PG, Thielke S, Kaye J, A smart-home system to unobtrusively and continuously assess loneliness in older adults, IEEE Journal of Translational Engineering in Health and Medicine. 2016 June 21, doi: 10.1109/JTEHM.2016.2579638, vol.

      Petersen J, Kaye J, Jacobs PG, Quinones A, Dodge H, Arnold A, Thielke S. Longitudinal Relationship Between Loneliness and Social Isolation in Older Adults: Results From the Cardiovascular Health Study. J Aging Health. 2016 Aug;28(5):775-95. doi: 10.1177/0898264315611664. Epub 2015 Oct 21. PubMed PMID: 26491043;PubMed Central PMCID: PMC4840102.

      Shastry, S.C., Asgari, M., Wan, E.A., Leitschuh, J., Preiser, N., Folsom, J., Condon, J., Cameron, M., Jacobs, P.G. 38th "Conext-aware fall detection using inertial sensors and time-of-flight transceivers", Annual International Conference of the IEEE Engineering in Medicine and Biology Society in Orlando, 2016.
      Resalat, N., El Youssef, J.E., Reddy, R., Jacobs, PG. "Design of a dual-hormone model predictive control for artificial pancreas with exercise model", Annual International Conference of the IEEE Engineering in Medicine and Biology Society in Orlando, 2016, in press.

        2015

        Jacobs PG, Resalat N, El Youssef J, Reddy R, Branigan D, Preiser N, Condon J, Castle J, Incorporating an exercise detection, grading, and hormone dosing algorithm into the artificial pancreas using accelerometry and heart rate, Journal of Diabetes Science and Technology, 2015 Oct 5;9(6):1175-84. doi: 10.1177/1932296815609371. PubMed PMID: 26438720; PubMed Central PMCID: PMC4667295.

        Castle JR, El Youssef J, Bakhtiani PA, Cai Y, Stobbe JM, Branigan D, Ramsey K, Jacobs P, Reddy R, Woods M, Ward, KM. Effect of Repeated Glucagon Doses on Hepatic Glycogen in Type 1 Diabetes: Implications for a Bi-Hormonal Closed-loop System. Diabetes Care. 2015 Nov;38(11):2115-9. doi: 10.2337/dc15-0754. Epub 2015 Sep 4. PubMed PMID: 26341131; PubMed Central PMCID: PMC4613914.

        Du X, Durgan CJ, Matthews DJ, Motley JR, Tan X, Pholsena K, Armadottier L, Castle JR, Jacobs PG, Cargill RS, Ward WK, Conley JF, Herman GS. Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes. ECS J. Solid State Sci. Technol.. 2015;4(4):3069-3074

        Bakhtiani, P., El Youssef, J., Jacobs P.G., Branigan, D., Castle, J., Ward, K., Factors affecting the success of glucagon delivered during an automated closed-loop system in type 1 diabetes, Journal of Diabetes and its Complications, 2015, 29(1), 93-98. PMID: 25264232

        Jacobs, P.G, Kaye, J.A., "Ubiquitous real-world sensing and audiology-based health informatics", Journal of the American Academy of Audiology, 2015 Oct;26(9):777-83. doi: 10.3766/jaaa.15010. PubMed PMID: 26415971.

        Dille, M.F., McMillan, G. P., Helt, W.J., Jacobs, P.G. "A store-and-forward teleaudiology solution for remote ototoxicity screenings: self-test vs. audiologist testing", Journal of the American Academy of Audiology, 2015 Oct;26(9):750-60. doi: 10.3766/jaaa.15028. PubMed PMID: 26415968; PubMed Central PMCID: PMC4632849.

        Schafermeyer E, Wan EA, Samin S, Zentzis N, Preiser N, Condon J, Folsom J, Jacobs PG. Multi-Resident Identification using Device-free IR and RF Fingerprinting. Annual International Conference of the IEEE Engineering in Medicine and Biology Society in MiCo. 5481-5484, 2015.

        Beattie Z, Jacobs PG, Riley T, Hagen C. A Time-Frequency Respiration Tracking System using Non-Contact Bed Sensors with Harmonic Artifact Rejection. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in MiCo, 8111-8184, 2015. 

          2014

          Bakhtiani, P., El Youssef, J., Jacobs P.G., Branigan, D., Castle, J., Ward, K., Factors affecting the success of glucagon delivered during an automated closed-loop system in type 1 diabetes, Journal of Diabetes and its Complications, 2014. doi:10.1016/j.jdiacomp.2014.09.001

          Jacobs, PG, Saunders, GH, New opportunities and challenges for teleaudiology within Department of Veterans Affairs, J. Rehabil Res. Dev., 51(5):vii–xii. 2014. doi:10.1682/JRRD.2014.04.0093View PDF.

          Jacobs, P.G., Wan, E.A., Schafermeyer, E., Adenwala, F., Paul, A.S., Kaye, J. Measuring in-home walking speed using wall-mounted RF transceiver arrays, IEEE Engineering in Medicine and Biology Conference, 2014. doi:10.1145/2632048.2632097

          Paul, A.S., Wan, E.A., Schafermeyer,E., Adenwala, F., Preiser, N., Kaye, J., Jacobs, P.G., MobileRF: A robust device-free tracking system based on a hybrid neural network HMM classifier, Ubicomp, 2014. doi:/10.1145/2632048.2632097

          Jacobs, P.G., El Youssef, J., Castle, J., Bakhtiani, P., Branigan, D., Breen, M., Bauer, D., Preiser, N., Leonard, G., Stonex, T., Ward, W.K. Automated control of an adaptive bi-hormonal, dual-sensor artificial pancreas and evaluation during inpatient studies. IEEE Transactions on Biomedical Engineering, 2014. PubMedView PDF.

          Ward, W.K., Castle, J.R., Jacobs, P.G., Cargill, R.S., Can glucose be monitored accurately at the site of subcutaneous insulin delivery? Journal of Diabetes Science and Technology, 2014. doi:10.1177/1932296814522805

            2013

            Brummer, N.B., Rawson, J.A., Grimm, M.W., Tupper, P., Miller, A.J.L., Billings, C.J., Jacobs, P.G., Electrode selection and other design considerations for a modular portable single-channel EEG-augmented hearing aid, 6th International IEEEdoi:10.1109/NER.2013.6695964

            Dille, M.F., Jacobs, P.G., Gordon, S.Y., Helt, W.J., McMillan G.P. OtoID: a new extended frequency portable audiometer for ototoxicity monitoring, Journal of Rehabilitation Research & Development, 2013;50(7):997-1006. EMBS Conference on Neural Engineering, San Diego, Nov. 2013. pp. 431-434. View Online
            Jacobs, P.G. Remote assessment of health in older and frail adults living independently through mobility assessment. In Telehealthcare Computing and Engineering: Principles and Design, by Fei Hu, Science Publishers, 2013, pp. 61-84. doi:10.1201/b14770-5

            2012

            Jacobs PG, Silaski G, Wilmington D, Gordon S, Helt W, McMillan G, Fausti SA, Dille M. Development and evaluation of a portable audiometer for high-frequency screening of hearing loss from ototoxicity in homes/clinics. IEEE Transactions on Biomedical Engineering. 2012;59(11):3097-103. PubMed

            Jacobs PG, Konrad-Martin D, McMillan GP, McDermott D, Fausti SA, Kagen D, Wan EA. Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex. The Journal of the Acoustical Society of America. 2012;131(2):1296-306. doi:10.1121/1.3676609

            Wan, E.A., Paul, A.S., Jacobs, P.G., Tag-free RSSI Based Indoor Localization, Proceedings of the 2012 International Technical Meeting of The Institute of Navigation, Newport Beach, CA, January 2012, pp. 940-944. View Online

            2011

            El Youssef J, Castle JR, Branigan DL, Massoud RG, Breen ME, Jacobs PG, Bequette BW, Ward WK. A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes. Journal of Diabetes Science and Technology. 2011; 5(6):1312-26. PMCID: 3262697. PubMedView PDF

            Jacobs PG, El Youssef J, Castle JR, Engle JM, Branigan DL, Johnson P, Massoud R, Kamath A, Ward WK. Development of a fully automated closed loop artificial pancreas control system with dual pump delivery of insulin and glucagon. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:397-400. PubMeddoi:10.1109/IEMBS.2011.6090127

            Paul, A. Wan E.A., Jacobs, P.G. Sigma-point Kalman Smoothing for Indoor Tracking and Auto-calibration Using Time-of-flight Ranging. Proceedings of the 24th International Technical Meeting of The Satellite Division of the Institute of Navigation (ION GNSS 2011), Portland, OR, September 2011, pp. 3461-3469. View Online

            Jacobs, P.G., Paul, A. Wan E.A. EmbedRF Position Tracking and Mobility Assessment System: A Low-power and Low-cost System for Passive Assessment of Patient Health in a Home Health-care Setting. Proceedings of the 24th International Technical Meeting of The Satellite Division of the Institute of Navigation (ION GNSS 2011), Portland, OR, September 2011, pp. 1499-1506. View Online

            2010 and earlier

            Dille MF, McMillan GP, Reavis KM, Jacobs P, Fausti SA, Konrad-Martin D. Ototoxicity risk assessment combining distortion product otoacoustic emissions with a cisplatin dose model. The Journal of the Acoustical Society of America. 2010; 128(3):1163-74. PubMeddoi:10.1121/1.3473693

            Jacobs PG, Wan EA, Konrad-Martin D. On correlating otoacoustic emissions with blood glucose levels. Conf Proc IEEE Eng Med Biol Soc.2008; 2008:4704-7. PubMeddoi:10.1109/IEMBS.2008.4650263

            Saunders G, Forsline A, Jacobs PG. The Attitudes towards Loss of Hearing Questionnaire (ALHQ): A comparison of paper and electronic formats. Journal of the American Academy of Audiology. 2007; 18(1):66-77. PubMeddoi:10.3766/jaaa.18.1.6

            Gilligan BC, Shults M, Rhodes RK, Jacobs PG, Brauker JH, Pintar TJ, Updike SJ. Feasibility of continuous long-term glucose monitoring from a subcutaneous glucose sensor in humans. Diabetes Technology & Therapeutics. 2004; 6(3):378-86. PubMedView PDF

            Patents

            2013

            U.S. Patent Pending (Application number: 61/624,097): Systems and methods for hearing loss screening and monitoring

              2012

              U.S. Patent #8,317,700: Method and Device for Non-Invasive Analyte Measurement

                2011

                U.S. Patent #7,976,466: Use of Multiple Data Points and Filtering in an Analyte Sensor
                U.S. Patent #8,810,388: Position tracking and mobility assessment system
                U.S. Patent Pending (Application number: 61/570382): A dual-use subcutaneous catheter for amperometric glucose sensing and hormone delivery

                2003

                U.S. Patent #6,558,321: Systems and methods for remote monitoring and modulation of medical devices