1:00 - 4:00 p.m., June 17, 2025

Location: Richard T. Jones Hall 4320

Recording available to OHSU attendees

Featured speakers:

• Stuart A. Lipton, M.D., Ph.D.
  
  Professor and Founding Director, Neurodegeneration New medicine Center
  
  The Scripps Research Institute
  
  "'Dark' Pathways of Protein Transnitrosylation Injure Synapses in Alzheimer’s Disease: Mechanism and Potential Treatment"
• Alice S. Chen-Plotkin, M.D.
  
  Professor of Neurology
  
  University of Pennsylvania
  
  "From Screens to Mechanisms in Parkinsons Disease"
• Lorraine Kalia, M.D., Ph.D.
  
  Associate Professor of Neurology
  
  University of Toronto
  
  "Interaction between alpha-synuclein and ESCRT: a potential therapeutic target for Parkinson's disease”
• Tony Wyss-Coray, Ph.D.
  
  Professor of Neurology
  
  Stanford University
  
  "Impaired synaptic protein turnover with aging and neurodegeneration"

Past Jungers Symposia

2024 Proteinopathies in Neurodegenerative Disease

Featured speakers:

• Virginia Lee, Ph.D.
  
  University of Pennsylvania
  
  Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression
• Susanne van Veluw, PhD.
  
  Harvard Medical School
  
  Mechanisms of microvascular injury in cerebral amyloid angiopathy
• Vikram Khurana, M.D., Ph.D.
  
  Brigham and Women’s Hospital and Harvard Medical School
  
  The Systems Cell Biology of Alpha-Synuclein: From New Functions to Targeted Therapeutics
• Michelle Gray, Ph.D.
  
  University of Alabama at Birmingham
  
  Astrocyte-interneuron interaction in Huntington’s disease

2023 Neurodegeneration & Repair Mechanisms

Recording available to OHSU attendees 

Featured speakers:

• Martha Bhattacharya, Ph.D.
  
  Brigham and Women’s Hospital and Harvard Medical School
  
  Genetic Analysis of Parkonism
• Kelvin Luk, Ph.D.
  
  University of Pennsylvania
  
  Can alpha-synuclein propagation patterns predict disease trajectory?
• Trent Watkins, Ph.D.
  
  University of California at San Francisco
  
  Harnessing Cellular Stress Signaling for Neuroprotection and Repair
• Mel Feany, M.D., Ph.D.
  
  Brigham and Women’s Hospital and Harvard Medical School
  
  Genetic Analysis of Parkonism

2022 Neurovascular Interactions

Recording available to OHSU attendees 

Featured speakers:

• Richard Daneman, Ph.D.
  
  University of California, San Diego
  
  Regulation of the Blood-Brain Barrier in Health and Disease
• Cam Ha Tran, Ph.D.
  
  University of Nevada, Reno
  
  The Role of Neuromodulatory Signaling in Neurovascular Coupling
• Harald Sontheimer, Ph.D.
  
  University of Virginia
  
  Glial, Neuronal, Vascular Interactions in Neurological Disease

2021  Wrapping the axons: The mysteries of myelination

Recording available to OHSU attendees

Featured speakers:

• Mikael Simmons, M.D.
  
  Institute of Neuronal Cell Biology, Technical University of Munich
  
  Mechanisms of remyelination and neuroprotection
• Wendy Macklin, Ph.D.
  
  Anschutz Medical Campus, University of Colorado
  
  A clinically relevant demyelination/remyelination model: Role of microglia
• Michelle Monje, M.D., Ph.D.
  
  Stanford University
  
  Neuron-glia interactions in health and disease: From cognition to cancer
• Stephen Hauser, M.D.
  
  Weill Institute for Neurosciences, University of California, San Francisco
  
  Multiple sclerosis: Past, present and future

2019  Glial-Neuronal Interactions in Health & Disease

Featured speakers:

• Aakanksha Singhvi, Ph.D.
  
  Fred Hutchinson Cancer Research Center
  
  Molecular mechanisms of glia-neuron interactions in C. elegans
• James Salzer, M.D., Ph.D.
  
  New York University
  
  Axo-glial interactions & the assembly of myelinated fibers
• Sarah Kucenas, Ph.D.
  
  ​University of Virginia
  
  Migratory neural crest cells phagocytose cellular debris in the developing nervous system
• Beth Stevens, Ph.D.
  
  Harvard University
  
  Microglia function & dysfunction in Alzheimer's Disease

2016 RNA Granules: From Synaptic Plasticity to Neurodegeneration

Featured speakers:

• Kelsey Martin, M.D., Ph.D.
  
  Professor of Biological Chemistry, Psychiatry and Biobehavioral Sciences Exec Vice Dean and Assoc Vice Chancellor, David Geffen School of Medicine, UCLA 
  
  Spatial regulation of gene expression during synaptic plasticity
• Jennifer Darnell, Ph.D.
  
  Research Associate Professor
  
  Laboratory of Molecular Neuro-oncology
  
  Rockefeller University
  
  Translational Control by the Fragile X Mental Retardation Protein: Targets and Mechanism
• Benjamin Wolozin, M.D., Ph.D.
  
  Department of Pharmacology and Neurology Laboratory of Neurodegeneration Boston University School of Medicine
  
  Stress granules and Neurodegeneration: A molecular network underlying neurodegeneration
• J Paul Taylor, M.D., Ph.D.
  
  Chair, Cell and Molecular Biology, St Jude’s Children’s Research Hospital Investigator, HHMI
  
  Perturbed RNA granule dynamics in ALS and related diseases

2015 Jungers Center Plenary Lecturer

Featured speaker:

• Moritz Helmstaedter
  
  Dr. med., Dipl.-Phys., Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
  
  Connectomics - the dense reconstruction of neuronal circuits

2014 Jungers Center Symposium - The genetics and genomics of neuropsychiatric disease

Featured speakers:

• James Lupski, M.D., Ph.D.
  
  Baylor College of Medicine
  
  Personal Genomes and Clan Genomics
• Stephan Züchner, M.D., Ph.D.
  
  University of Miami
  
  From new tools to discovery: the contribution of rare genomic variation to disease

2013 Jungers Center Symposium- Neurodegeneration: New Mechanisms and New Insights

Featured speakers:

• Karen Duff, Ph.D.
  
  Columbia University
  
  Propagation of Alzheimer's pathology through the brain-mechanistic insights and therapeutic opportunities
• Gary Bassell, Ph.D.
  
  Emory University
  
  mRNA traffic, local translation and neurodegenerative disease
• Aaron Gitler, Ph.D.
  
  Stanford University
  
  High-throughput genetic screens to define mechanisms of human neurodegenerative diseases Don Cleveland, Ph.D.,University of California, San Diego
  
  From Charcot to Lou Gehrig: Mechanism and therapy in ALS and beyond

2012 Jungers Center Symposium - New Imaging Technologies, New Insights into the Brain

Featured speakers:

• Jeff Lichtman, M.D.
  
  Harvard University
  
  Using connectomics to reveal circuit motifs
• Tim Holy, Ph.D.
  
  Washington University
  
  Getting a feeling for the circuit: Imaging neuronal ensembles with Objective-Coupled Planar Illumination Microscopy
• Tianyi Mao, Ph.D.
  
  Vollum Institute
  
  Imaging of Functional Connectivity in Cortical and Subcortical Circuits
• Tim Murphy, Ph.D.
  
  University of British Columbia
  
  In Vivo Imaging of Cortical Circuits, Before, During and After Ischemia

2011 Jungers Center Symposium - Repairing the nervous system: Lessons from flies, fish, and mice

Featured speakers:

• Michael Coleman, Ph.D.
  
  Babraham Institute, Cambridge
  
  From long-lived axons to a short-lived protein: WldS and Nmnat2
• Christine Beattie, Ph.D.
  
  Ohio State University, Columbus
  
  Modeling human motoneuron diseases in zebrafish: Approaches and outcomes
• Aaron DiAntonio, Ph.D.
  
  Washington University, St. Louis
  
  The axonal injury response: Lessons from flies and mice
• Tony Wyss-Coray, Ph.D.
  
  Stanford University
  
  A novel role for TGF-beta signaling in adult neurogenesis

2010 Jungers Center Symposium - Glial-Neuronal Interactions: Implications for Neurologic Diseases

Featured speakers:

• Klaus-Armin Nave, Ph.D.
  
  Max-Planck-Institute of Experimental Medicine, Göttingen
  
  Myelination and the glial support of axon function
• Elior Peles, Ph.D.
  
  Weizmann Institute
  
  How Schwann cells assemble Nodes of Ranvier
• William S. Talbot, Ph.D.
  
  Stanford University
  
  Glial development and myelination in zebrafish
• Jonah Chan, Ph.D.
  
  University of California, San Francisco
  
  Maximizing the myelinogenic potential of individual oligodendrocytes for repair

2009 Jungers Center Symposium - Axonal Degeneration and Regeneration: Towards an understanding of the pathogenesis of multiple sclerosis, Alzheimer's and related diseases

Featured speakers:

• Marc Freeman, Ph.D.
  
  University of Massachusetts
  
  Axon auto-destruction and glial immune functions during Wallerian degeneration
• Julie Pinkston-Gosse, Ph.D.
  
  Genentech
  
  Common mechanisms of axonal degeneration and regeneration block
• Marie Filbin, Ph.D.
  
  Hunter College
  
  Signaling axonal regeneration in the adult CNS
• Martin Kerschensteiner, Ph.D.
  
  Ludwig-Maximilians University, Munich
  
  In vivo pathogenesis of immune-mediated axon damage