Jungers Center Symposia

Proteinopathies in Neurodegenerative Disease

1:00 – 4:00 pm, May 14th, 2024

Featured speakers:

  • Virginia Lee, Ph.D.
    University of Pennsylvania
    Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression
  • Susanne van Veluw, PhD.
    Harvard Medical School
    Mechanisms of microvascular injury in cerebral amyloid angiopathy
  • Vikram Khurana, M.D., Ph.D.
    Brigham and Women’s Hospital and Harvard Medical School
    The Systems Cell Biology of Alpha-Synuclein: From New Functions to Targeted Therapeutics
  • Michelle Gray, Ph.D.
    University of Alabama at Birmingham
    Astrocyte-interneuron interaction in Huntington’s disease

More information can be found here.

Past Jungers symposia

    2023 Neurodegeneration & Repair Mechanisms
    Recording available to OHSU attendees 
    Featured speakers:

    • Martha Bhattacharya, Ph.D.
      Brigham and Women’s Hospital and Harvard Medical School
      Genetic Analysis of Parkonism
    • Kelvin Luk, Ph.D.
      University of Pennsylvania
      alpha-synuclein propagation patterns predict disease trajectory?
    • Trent Watkins, Ph.D.
      University of California at San Francisco
      Cellular Stress Signaling for Neuroprotection and Repair
    • Mel Feany, M.D., Ph.D.
      Brigham and Women’s Hospital and Harvard Medical School
      Genetic Analysis of Parkonism

    2022 Neurovascular Interactions
    Recording available to OHSU attendees 
    Featured speakers:

    • Richard Daneman, Ph.D.
      University of California, San Diego
      Regulation of the Blood-Brain Barrier in Health and Disease
    • Cam Ha Tran, Ph.D.
      University of Nevada, Reno
      The Role of Neuromodulatory Signaling in Neurovascular Coupling
    • Harald Sontheimer, Ph.D.
      University of Virginia
      Glial, Neuronal, Vascular Interactions in Neurological Disease

    2021  Wrapping the axons: The mysteries of myelination, key speakers:
    Recording available to OHSU attendees

    • Mikael Simmons, M.D.
      Institute of Neuronal Cell Biology, Technical University of Munich
      Mechanisms of remyelination and neuroprotection
    • Wendy Macklin, Ph.D.
      Anschutz Medical Campus, University of Colorado
      A clinically relevant demyelination/remyelination model: Role of microglia
    • Michelle Monje, M.D., Ph.D.
      Stanford University
      Neuron-glia interactions in health and disease: From cognition to cancer
    • Stephen Hauser, M.D.
      Weill Institute for Neurosciences, University of California, San Francisco
      Multiple sclerosis: Past, present and future

    2019  Glial-Neuronal Interactions in Health & Disease, key speakers:

    • Aakanksha Singhvi, Ph.D.
      Fred Hutchinson Cancer Research Center
      Molecular mechanisms of glia-neuron interactions in C. elegans
    • James Salzer, M.D., Ph.D.
      New York University
      Axo-glial interactions & the assembly of myelinated fibers
    • Sarah Kucenas, Ph.D.
      ​University of Virginia
      Migratory neural crest cells phagocytose cellular debris in the developing nervous system
    • Beth Stevens, Ph.D.
      Harvard University
      Microglia function & dysfunction in Alzheimer's Disease

    2016 RNA Granules: From Synaptic Plasticity to Neurodegeneration, key speakers:

    • Kelsey Martin, M.D., Ph.D.
      Professor of Biological Chemistry, Psychiatry and Biobehavioral Sciences Exec Vice Dean and Assoc Vice Chancellor, David Geffen School of Medicine, UCLA 
      Spatial regulation of gene expression during synaptic plasticity
    • Jennifer Darnell, Ph.D.
      Research Associate Professor
      Laboratory of Molecular Neuro-oncology
      Rockefeller University
      Translational Control by the Fragile X Mental Retardation Protein: Targets and Mechanism
    • Benjamin Wolozin, M.D., Ph.D.
      Department of Pharmacology and Neurology Laboratory of Neurodegeneration Boston University School of Medicine
      Stress granules and Neurodegeneration: A molecular network underlying neurodegeneration
    • J Paul Taylor, M.D., Ph.D.
      Chair, Cell and Molecular Biology, St Jude’s Children’s Research Hospital Investigator, HHMI
      Perturbed RNA granule dynamics in ALS and related diseases

    2015 Jungers Center Plenary Lecturer, featured speaker:

    • Moritz Helmstaedter
      Dr. med., Dipl.-Phys., Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany

      Connectomics - the dense reconstruction of neuronal circuits

    2014 Jungers Center Symposium - The genetics and genomics of neuropsychiatric disease, featured speakers:

    • James Lupski, M.D., Ph.D.
      Baylor College of Medicine

      Personal Genomes and Clan Genomics
    • Stephan Züchner, M.D., Ph.D.
      University of Miami

      From new tools to discovery: the contribution of rare genomic variation to disease

    2013 Jungers Center Symposium- Neurodegeneration: New Mechanisms and New Insights, featured speakers:

    • Karen Duff, Ph.D.
      Columbia University

      Propagation of Alzheimer's pathology through the brain-mechanistic insights and therapeutic opportunities
    • Gary Bassell, Ph.D.
      Emory University

      mRNA traffic, local translation and neurodegenerative disease
    • Aaron Gitler, Ph.D.
      Stanford University
      High-throughput genetic screens to define mechanisms of human neurodegenerative diseases Don Cleveland, Ph.D.,University of California, San Diego
      From Charcot to Lou Gehrig: Mechanism and therapy in ALS and beyond

    2012 Jungers Center Symposium - New Imaging Technologies, New Insights into the Brain, featured speakers:

    • Jeff Lichtman, M.D.
      Harvard University

      Using connectomics to reveal circuit motifs
    • Tim Holy, Ph.D.
      Washington University

      Getting a feeling for the circuit: Imaging neuronal ensembles with Objective-Coupled Planar Illumination Microscopy
    • Tianyi Mao, Ph.D.
      Vollum Institute

      Imaging of Functional Connectivity in Cortical and Subcortical Circuits
    • Tim Murphy, Ph.D.
      University of British Columbia

      In Vivo Imaging of Cortical Circuits, Before, During and After Ischemia

    2011 Jungers Center Symposium - Repairing the nervous system: Lessons from flies, fish, and mice, featured speakers:

    • Michael Coleman, Ph.D.
      Babraham Institute, Cambridge

      From long-lived axons to a short-lived protein: WldS and Nmnat2
    • Christine Beattie, Ph.D.
      Ohio State University, Columbus

      Modeling human motoneuron diseases in zebrafish: Approaches and outcomes
    • Aaron DiAntonio, Ph.D.
      Washington University, St. Louis

      The axonal injury response: Lessons from flies and mice
    • Tony Wyss-Coray, Ph.D.
      Stanford University

      A novel role for TGF-beta signaling in adult neurogenesis

    2010 Jungers Center Symposium - Glial-Neuronal Interactions: Implications for Neurologic Diseases, featured speakers:

    • Klaus-Armin Nave, Ph.D.
      Max-Planck-Institute of Experimental Medicine, Göttingen

      Myelination and the glial support of axon function
    • Elior Peles, Ph.D.
      Weizmann Institute

      How Schwann cells assemble Nodes of Ranvier
    • William S. Talbot, Ph.D.
      Stanford University

      Glial development and myelination in zebrafish
    • Jonah Chan, Ph.D.
      University of California, San Francisco

      Maximizing the myelinogenic potential of individual oligodendrocytes for repair

    2009 Jungers Center Symposium - Axonal Degeneration and Regeneration: Towards an understanding of the pathogenesis of multiple sclerosis, Alzheimer's and related diseases, featured speakers:

    • Marc Freeman, Ph.D.
      University of Massachusetts

      Axon auto-destruction and glial immune functions during Wallerian degeneration
    • Julie Pinkston-Gosse, Ph.D.

      Common mechanisms of axonal degeneration and regeneration block
    • Marie Filbin, Ph.D.
      Hunter College

      Signaling axonal regeneration in the adult CNS
    • Martin Kerschensteiner, Ph.D.
      Ludwig-Maximilians University, Munich

      In vivo pathogenesis of immune-mediated axon damage

    Scenes from past symposia

    Photo collage with scenes of people speaking and attending Jungers Symposia, including Frank and Julie Jungers