Pachyonychia Congenita

Histological view at pachyonychia congenita

For over 15 years, Dr. Leachman has led a translational research program for pachyonychia congenita (PC), an autosomal dominant keratin disorder caused by dominant negative mutations in keratins 6a, 6b, 6c, 16, and 17. She founded the International Pachyonychia Congenita Consortium, a collaborative international team of academic, philanthropic and industry partners. Together, this consortium built the International PC Research Registry to support research into this challenging disease.

Through these efforts, Dr. Leachman led the first clinical trial of a siRNA agent in skin, and she continues to pursue PC studies and clinical trials at OHSU in collaboration with Dr. Tracy Funk.

Dr. Leachman and Dr. Funk are both members of the Medical and Scientific Advisory Board of the Pachyonychia Congenita Project.

Find out more about our Pachyonychia Congenita research by visiting our Publications Page.