Clinical Flow Cytometry Laboratory

The OHSU Clinical Flow Cytometry Laboratory provides comprehensive diagnostic and specialized flow cytometric testing to support the diagnosis, classification, and monitoring of hematologic malignancies, immune disorders, and other clinical conditions.

Our laboratory utilizes advanced multiparameter flow cytometry, including 13-color assays (Beckman Coulter DxFlex), to characterize hematopoietic and immune cell populations. In addition to routine diagnostic immunophenotyping, we offer specialized testing for measurable residual disease (MRD), chimeric antigen receptor T-cell (CAR-T) monitoring, and other clinical applications.

Our team of hematopathologists and clinical laboratory professionals works closely with treating physicians to provide accurate, timely, and clinically relevant results.

Flow Lab test menus

Hematologic Malignancies

• Acute myeloid and lymphoblastic leukemias
• Mature B-cell lymphomas and leukemias
• Mature T-cell and NK-cell neoplasms
• Plasma cell neoplasms
• Myelodysplastic and myeloproliferative neoplasms

Measurable Residual Disease (MRD)

• B-lymphoblastic leukemia MRD  

CAR-T Cell Monitoring

• CD19-directed CAR-T cell detection and monitoring
• BCMA-directed CAR-T cell detection and monitoring
• Testing of peripheral blood, bone marrow, and cerebrospinal fluid specimens

Immunologic and Other Specialized Testing

• Lymphocyte subset analysis
• Immune reconstitution, immune deficiency, and Autoimmune Lymphoproliferative Syndrome (ALPS) assessment
• CD34-positive hematopoietic progenitor cell enumeration
• Paroxysmal nocturnal hemoglobinuria (PNH) testing
• Fetal red blood cells (fRBCs)
• Platelet surface markers for hereditary platelet disorders
• Other specialized assays (see current test directory)

Flow sorting

• Chimerism cell sort
• Other tests (FISH, NGS) cell sort

For test-specific information, including specimen requirements, collection instructions, and assay availability, please refer to the Test Directory webpage and select Flow Cytometry as the Lab Section. If you have further questions, please contact Laboratory Client Services at 503-494-7383.