EAC Publications

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Bonnemaison ML, Bäck N, Duffy ME, Ralle M, Mains RE, Eipper BA. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015 Jul 13. pii: jbc.M115.641027. [Epub ahead of print]. PubMed Link for this article

Tallino S, Duffy M, Ralle M, Cortés MP, Latorre M, Burkhead JL. Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease. J Nutr Biochem. 2015 May 15. pii: S0955-2863(15)00108-4. doi: 10.1016/j.jnutbio.2015.04.009. [Epub ahead of print]. PubMed Link for this Article 


Voss K, Harris C, Ralle M, Duffy M, Murchison C, Quinn JF. Modulation of tau phosphorylation by environmental copper. Transl Neurodegener. 2014 Nov 17;3(1):24. doi: 10.1186/2047-9158-3-24. eCollection 2014. PubMed Link for this Article

Gaier ED, Kleppinger A, Ralle M, Covault J, Mains RE, Kenny AM, Eipper BA. Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum. BMC Endocr Disord. 2014 Jul 15;14:58. doi: 10.1186/1472-6823-14-58. PubMed Link for this Article

Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE. In vivo and in vitro analyses of amygdalar function reveal a role for copper. J Neurophysiol. 2014 May;111(10):1927-39. doi: 10.1152/jn.00631.2013. Epub 2014 Feb 19. PubMed Link for this Article 

Harris CJ, Voss K, Murchison C, Ralle M, Frahler K, Carter R, Rhoads A, Lind B, Robinson E, Quinn JF. Oral zinc reduces amyloid burden in Tg2576 mice. BMC Endocr Disord. 2014 Jul 15;14:58. doi: 10.1186/1472-6823-14-58. PubMed Link for this Article


Öhrvik H, Nose Y, Wood LK, Kim BE, Gleber SC, Ralle M, Thiele DJ. Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4279-88. doi: 10.1073/pnas.1311749110. Epub 2013 Oct 28. PubMed Link for this Article

Gaier ED, Miller MB, Ralle M, Aryal D, Wetsel WC, Mains RE, Eipper BA. Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem. 2013 Dec;127(5):605-19. doi: 10.1111/jnc.12438. Epub 2013 Oct 13. PubMed Link for this Article  

Vogt S, Ralle M. Opportunities in multidimensional trace metal imaging: taking copper-associated disease research to the next level. Anal Bioanal Chem. 2013 Feb;405(6):1809-20. doi: 10.1007/s00216-012-6437-1. Epub 2012 Oct 19. PubMed Link for this Article


Gray LW, Peng F, Molloy SA, Pendyala VS, Muchenditsi A, Muzik O, Lee J, Kaplan JH, Lutsenko S. Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load. PLoS One. 2012;7(6):e38327. doi: 10.1371/journal.pone.0038327. Epub 2012 Jun 22.  PubMed Link for this Article

Vyleta ML, Wong J, Magun BE. Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome. PLoS One. 2012;7(5):e36044. doi: 10.1371/journal.pone.0036044. Epub 2012 May 14. PubMed Link for this Article

Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA. High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol. 2012 Jul;47(7):491-6. doi: 10.1016/j.exger.2012.03.014. Epub 2012 Mar 29. PubMed Link for this Article

Yeh S, Ralle M, Phan IT, Francis PJ, Rosenbaum JT, Flaxel CJ. Occult intraocular foreign body masquerading as panuveitis: inductively coupled mass spectrometry and electrophysiologic analysis. J Ophthalmic Inflamm Infect. 2012 Jun;2(2):99-103. doi: 10.1007/s12348-011-0035-9. Epub 2011 Jul 31. PubMed Link for this Article


Burkhead JL, Ralle M, Wilmarth P, David L, Lutsenko S. Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease. J Mol Biol. 2011 Feb 11;406(1):44-58. doi: 10.1016/j.jmb.2010.12.001. Epub 2010 Dec 10. PubMed Link for this Article

Quinn JF, Harris C, Kaye JA, Lind B, Carter R, Anekonda T, Ralle M. Gender effects on plasma and brain copper. Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19. PubMed Link for the Article

Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF. Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35. doi: 10.3233/JAD-2010-101287. PubMed Link for this Article


Ralle M, Huster D, Vogt S, Schirrmeister W, Burkhead JL, Capps TR, Gray L, Lai B, Maryon E, Lutsenko S. Wilson disease at a single cell level: intracellular copper trafficking activates compartment-specific responses in hepatocytes. J Biol Chem. 2010 Oct 1;285(40):30875-83. doi: 10.1074/jbc.M110.114447. Epub 2010 Jul 20. PubMed Link for this Article

LeShane ES, Shinde U, Walker JM, Barry AN, Blackburn NJ, Ralle M, Lutsenko S. Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B. J Biol Chem. 2010 Feb 26;285(9):6327-36. doi: 10.1074/jbc.M109.074633. Epub 2009 Dec 23. PubMed Link for this Article

Quinn JF, Harris CJ, Cobb KE, Domes C, Ralle M, Brewer G, Wadsworth TL. A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;21(3):903-14. doi: 10.3233/JAD-2010-100408. PubMed Link for this Article


Bartee MY, Ralle M, Lutsenko S. The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k. PubMed Link for this Article

Ralle M, Lutsenko S. Quantitative imaging of metals in tissues. Biometals. 2009 Feb;22(1):197-205. doi: 10.1007/s10534-008-9200-5. Epub 2009 Jan 7. Review. PubMed Link for this Article


Huster D, Purnat TD, Burkhead JL, Ralle M, Fiehn O, Stuckert F, Olson NE, Teupser D, Lutsenko S. High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J Biol Chem. 2007 Mar 16;282(11):8343-55. Epub 2007 Jan 7. PubMed Link for this Article

Bauman AT, Ralle M, Blackburn NJ. Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor. Protein Expr Purif. 2007 Jan;51(1):34-8. Epub 2006 Jun 27. PubMed Link for this Article


Nakano S, Erwin KN, Ralle M, Zuber P. Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx. Mol Microbiol. 2005 Jan;55(2):498-510. PubMed Link for this Article


Ralle M, Berry SM, Nilges MJ, Gieselman MD, van der Donk WA, Lu Y, Blackburn NJ. The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc. 2004 Jun 16;126(23):7244-56. PubMed Link for this Article

Ralle M, Lutsenko S, Blackburn NJ. Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B): X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands. J Inorg Biochem. 2004 May;98(5):765-74. PubMed Link for this Article

Walker JM, Huster D, Ralle M, Morgan CT, Blackburn NJ, Lutsenko S. The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1. J Biol Chem. 2004 Apr 9;279(15):15376-84. Epub 2004 Jan 30. PubMed Link for this Article


Berry SM, Ralle M, Low DW, Blackburn NJ, Lu Y. Probing the role of axial methionine in the blue copper center of azurin with unnatural amino acids. J Am Chem Soc. 2003 Jul 23;125(29):8760-8. PubMed Link for this Article

Ralle M, Lutsenko S, Blackburn NJ. X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines. J Biol Chem. 2003 Jun 20;278(25):23163-70. Epub 2003 Apr 9. PubMed Link for this Article


Eisses JF, Stasser JP, Ralle M, Kaplan JH, Blackburn NJ. Domains I and III of the human copper chaperone for superoxide dismutase interact via a cysteine-bridged Dicopper(I) cluster. Biochemistry. 2000 Jun 27;39(25):7337-42. PubMed Link for this Article

Blackburn NJ, Rhames FC, Ralle M, Jaron S. Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism. J Biol Inorg Chem. 2000 Jun;5(3):341-53. PubMed Link for this Article

Blackburn NJ, Ralle M, Hassett R, Kosman DJ. Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase. Biochemistry. 2000 Mar 7;39(9):2316-24. PubMed Link for this Article


Ralle M, Verkhovskaya ML, Morgan JE, Verkhovsky MI, Wikström M, Blackburn NJ. Coordination of CuB in reduced and CO-liganded states of cytochrome bo3 from Escherichia coli. Is chloride ion a cofactor? Biochemistry. 1999 Jun 1;38(22):7185-94. PubMed Link for this Article

Blackburn NJ, Ralle M, Gomez E, Hill MG, Pastuszyn A, Sanders D, Fee JA. Selenomethionine-substituted Thermus thermophilus cytochrome ba3: characterization of the CuA site by Se and Cu K-EXAFS. Biochemistry. 1999 Jun 1;38(22):7075-84. PubMed Link for this Article