Diet and Blood Pressure: Seeking Answers

Our lab is dedicated to seeking answers to ongoing questions about human hypertension and kidney disease. 

We are also committed to sharing our techniques openly with fellow researchers and cultivating a larger community of transparency and research integrity.

Effect of Potassium on NaCl Transporter Abundance

Our current projects determine:

  • How potassium prevents hypertension
  • How the kidney senses potassium
  • How gene mutations cause hypertension
  • How aldosterone damages the heart and kidney

Pictured right: our findings on the effect of potassium on NaCl transporter abundance. Read more about them in Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride by Terker et al. 

Getting a Closer Look at the Kidney

By investing time in thinking creatively about developing new techniques, we can extend the depth of our findings. 

New technique of kidney clearing, showing aquaporin 2 (AQP2) in green and BrdU in purple.Pictured left: preliminary 3D rendering from immunofluorescence and clearing studies, showing mouse renal medulla tubules in striking clarity by tracking the protein aquaporin 2 (AQP2) in green.