Projects

Randomized Trial of Early Hemodynamic Management of Patients following Acute Spinal Cord Injury: TEMPLE

Miriam Treggiari, MD

Experiencing lower blood pressure is a common event following high spinal cord injury (SCI). Prevention of low blood pressure and early management in an Intensive Care Unit has saved lives and improved the functional results among survivors of SCI. When there is swelling of the spinal cord due to contusion, there is a window of opportunity to preserve some sections of the spinal cord near the level of injury, before they suffer irreversible damage. Today, it is unknown what blood pressure is optimal to help preserve these sections of the spinal cord at risk of ongoing damage. While it is known that managing blood pressure improves outcomes for patients, the best blood pressure range is not yet known. This study will provide guidance to care providers on how to manage blood pressure in the first week after the injury to achieve the best short- and long-term results to improve the life of victims of SCI. The objective of this study is to determine if targeted blood pressure manipulation will improve patient outcomes, including neurological function, functional independence, pain levels, and quality of life after SCI. The trial is currently enrolling participants in a multi-center, randomized, controlled study designed to assess the efficacy and safety of early targeted blood pressure management (TPM) in an intensive care unit (ICU) setting in adult patients with acute spinal cord injury involving the cervical and thoracic spine. Participating sites include Oregon Health and Science University (Clinical Site and Coordinating Center), University of Maryland, University of Pennsylvania, University of Cincinnati, and University of Washington.

Clinical Trials Identifier NCT02878850

Funding: Congressionally Directed Medical Research Program - US army –Department of Defense

 

An Assessor-Blinded, Randomized, Controlled, Single Center, Parallel Design Trial to Compare the Incidence of Postoperative Pulmonary Complications Associated with Rocuronium Neuromuscular Reversal with Sugammadex versus Neostigmine in Patients 70 Years of Age or Older Undergoing Surgery of at Least 3 Hours

Brandon Togioka, MD 

Common practice throughout the world is to reverse neuromuscular blockade at the end of surgery with neostigmine. Residual neuromuscular blockade after reversal with neostigmine is quite common with an incidence in the range of 30-55%. Substantial respiratory morbidity has been associated with this postoperative residual paralysis. A new drug with evidence of more complete neuromuscular reversal has been developed, sugammadex. Sugammadex is unique from neostigmine in that it can reverse all depths of neuromuscular blockade in a dose-dependent manner and it has been shown to virtually eliminate residual paralysis in the PACU, when administered in appropriate doses. The objective of this study is to determine if a strategy of rocuronium neuromuscular reversal with sugammadex will reduce the proportion of adult patients that develop a postoperative pulmonary complication, as compared with neostigmine. This single center, double-blind, randomized, controlled trial is currently enrolling participants at Oregon Health and Science University.

Clinical Trials Identifier NCT02861131

Funding: Merck Sharp & Dohme Corp