Studying how host defense mechanisms triggered by pathogenic microorganisms result in chronic inflammatory diseases. See our research.
The Rosenzweig Lab has a broad interest in the study of tissue injury and autoimmune disease. Although inflammation is essential for host defense against infection, its dysregulation contributes to a variety of rheumatologically-mediated disorders. Research efforts in the Rosenzweig lab support a new paradigm that autoimmunity develops from complex environmental and genetic interactions. Innate immune receptors (aka pattern recognition receptors, PRRs) exist at the interface of host-microbe interactions and play a pivotal role in defense against infection. The Lab's work has brought new insight into how cross-talk amongst PRRs is important in maintaining health (i.e. homeostasis) vs. autoimmune disease. The research program encompasses functional genetics, mechanisms that regulate autoreactive T cells, cellular and immunological approaches to study clinically relevant diseases that include uveitis, arthritis, Blau syndrome, and tissue injury responses of the eye and joints.