Rosenzweig Lab has a broad interest in the study of tissue injury and autoimmune disease. Although inflammation is essential for host defense against infection, its dysregulation contributes to a variety of rheumatologically-mediated disorders.
Research efforts in the Rosenzweig Lab support a new paradigm that autoimmunity develops from complex environmental and genetic interactions. Innate immune receptors (aka pattern recognition receptors, PRRs) exist at the interface of host-microbe interactions and play a pivotal role in defense against infection. The lab's work has brought new insight into how cross-talk amongst PRRs is important in maintaining health (i.e. homeostasis) vs. autoimmune disease. The research program encompasses functional genetics, mechanisms that regulate autoreactive T cells, cellular and immunological approaches to study clinically relevant diseases that include uveitis, arthritis, Blau syndrome and tissue injury responses of the eye and joints.
National Eye Institute at National Institutes of Health
Department of Veterans Affairs Laboratory Research and Development Service