Publications
Recent publications
Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
Ruth J Napier, Ellen J Lee, Emily E Vance, Paige E Snow, Kimberly A Samson, Clare E Dawson, Amy E Moran, Peter Stenzel, Michael P Davey, Shimon Sakaguchi, Holly L Rosenzweig. Journal of Immunology (2018) Oct 1;201(7):1889-1898. doi: 10.4049/jimmunol.1700507. Epub 2018 Aug 27.
T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi & Holly L. Rosenzweig. Nature Communications volume 11, Article number: 5406 (2020)
Mincle activation and the Syk/Card9 signaling axis are central to development of autoimmune disease of the eye.
Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Hinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL. Journal of Immunology (2016); 196(7): 3148-58. PMID: 26921309
Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.
Brown BB, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown G, Wells CA, Smith JR, Caspi RR, Rosenzweig HL. Clinical and Experimental Immunology (2017); Epub ahead of print. PMID: 28763100
A Blau syndrome-associated Nod2 mutation alters expression of full length NOD2 and limits responses to muramyl dipeptide in knock-in mice.
Dugan J, Griffiths E, Snow, P, Rosenzweig HL, Lee EJ, Brown B, Carr DW, Rose C, Rosenbaum JT, Davey MP. Journal of Immunology (2015); 194(1): 349-57. PMID: 25429073
Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice.
Lee EJ, Vance EE, Brown BR, Snow P, Clowers JS, Sakaguchi S, Rosenzweig HL. Arthritis Research & Therapy (2015); 17: 218. PMID: 26286534