Lab publications

Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.
Powers JM, Haese NN, Denton M, Ando T, Kreklywich C, Bonin K, Streblow CE, Kreklywich N, Smith P, Broeckel R, DeFilippis V, Morrison TE, Heise MT, Streblow DN. PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009308. doi: 10.1371/journal.pntd.0009308. eCollection 2021 Apr. PMID: 33793555

Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection.
Jones IKA, Orloff S, Burg JM, Haese NN, Andoh TF, Chambers A, Fei SS, Gao L, Kreklywich CN, Streblow ZJ, Enesthvedt K, Wanderer A, Baker J, Streblow DN. Am J Transplant. 2021 Jan;21(1):44-59. doi: 10.1111/ajt.16149. Epub 2020 Jul 18. PMID: 33405337

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.
Steinbach RJ, Haese NN, Smith JL, Colgin LMA, MacAllister RP, Greene JM, Parkins CJ, Kempton JB, Porsov E, Wang X, Renner LM, McGill TJ, Dozier BL, Kreklywich CN, Andoh TF, Grafe MR, Pecoraro HL, Hodge T, Friedman RM, Houser LA, Morgan TK, Stenzel P, Lindner JR, Schelonka RL, Sacha JB, Roberts VHJ, Neuringer M, Brigande JV, Kroenke CD, Frias AE, Lewis AD, Kelleher MA, Hirsch AJ, Streblow DN. PLoS One. 2020 Jan 14;15(1):e0227676. doi: 10.1371/journal.pone.0227676. eCollection 2020. PMID: 31935257

Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease.
Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN. Front Immunol. 2019 Oct 31;10:2563. doi: 10.3389/fimmu.2019.02563. eCollection 2019. PMID: 31736977

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.
Daniel N. Streblow, Alec J. Hirsch, Jeffrey J. Stanton, Anne D. Lewis, Lois Colgin, Ann J. Hessell, Craig N. Kreklywich, Jessica L. Smith, William F. Sutton, David Chauvin, Jennifer, Benjamin N. Bimber, Cierra N. LeBlanc, Sonia N. Acharya, Brian J. O’Roak, Harjinder Sardar, Mohammad M. Sajadi, Zahra R. Tehrani, Mark R. Walter, Luis Martinez-Sobrido, James J. Kobie, Rachel J. Reader, Katherine J. Olstad, Theodore R. Hobbs, Erica Ollmann Saphire, Sharon L. Schendel, Robert H. Carnahan, Jonas Knoch, Luis M. Branco, James E. Crowe, Jr., Koen K.A. Van Rompay, Phillip Lovalenti, Vu Truong, Donald N. Forthal, Nancy L. Haigwood, , Nature Communications , Nov, 2023                              

Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation. Medica S, Crawford LB, Denton M, Min CK, Jones TA, Alexander T, Parkins CJ, Diggins NL, Streblow GJ, Mayo AT, Kreklywich CN, Smith P, Jeng S, McWeeney S, Hancock MH, Yurochko A, Cohen MS, Caposio P, Streblow DN.