Publications

Selected publications

2023

  1. Bates, T.A., H.C. Leier, S.K. McBride, D. Schoen, Z.L. Lyski, D.X. Lee, W.B. Messer, M.E. Curlin, and F.G. Tafesse. 2023. The time between vaccination and infection impacts immunity against SARS-CoV-2 variants. medRxiv:2023.2001.2002.23284120.
  2. Guzman G, Creek C, Farley S, Tafesse FG. Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections. Methods Mol Biol. 2023;2610:1-16. doi: 10.1007/978-1-0716-2895-9_1. PMID: 36534277.

2022

  1. Bates TA, Lu P, Kang YJ, Schoen D, Thornton M, McBride SK, Park C, Kim D, Messer WB, Curlin ME, Tafesse FG, Lu LL. BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age. Cell Rep. 2022 Oct 25;41(4):111544. doi: 10.1016/j.celrep.2022.111544. Epub 2022 Oct 5. PMID: 36252569; PMCID: PMC9533669.
    News coverage: UTSW Center Times; Dallas Morning NewsMiami Herald; Tribune Democrat
  2. Curlin ME, Bates TA, Guzman G, Schoen D, McBride SK, Carpenter SD, Tafesse FG. Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection. Med (N Y). 2022 Dec 9;3(12):827-837.e3. doi: 10.1016/j.medj.2022.09.001. Epub 2022 Sep 22. PMID: 36198311; PMCID: PMC9492511.
    News coverage: OHSU News https://news.ohsu.edu/2022/04/20/booster-dose-and-breakthrough-infection-provide-similar-covid-super-immunity-study-finds
    OPB: https://www.opb.org/article/2022/05/18/oregon-health-authority-pandemic-not-over-but-it-has-changed-again/
  3. Bates TA, Lu P, Kang YJ, Schoen D, Thornton M, McBride SK, Park C, Kim D, Messer WB, Curlin ME, Tafesse FG, Lu LL. BNT162b2 induced neutralizing and non-neutralizing antibody functions against SARSCoV-2 diminish with age. medRxiv [Preprint]. 2022 Aug 16:2022.08.12.22278726. doi: 10.1101/2022.08.12.22278726.
  4. Schultz C, Farley SE, Tafesse FG. "Flash & Click": Multifunctionalized Lipid Derivatives as Tools To Study Viral Infections. J Am Chem Soc. 2022 Aug 10;144(31):13987-13995. doi: 10.1021/jacs.2c02705. Epub 2022 Jul 28. PMID: 35900117; PMCID: PMC9377334.
  5. Gelanew T, Mulu A, Abebe M, Bates TA, Wassie L, Teferi M, Fentahun D, Alemu A, Tamiru F, Assefa G, Bayih AG, Tafesse FG, Mihret A, Abdissa A. A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers. Vaccines (Basel). 2022 May 27;10(6):859. doi: 10.3390/vaccines10060859. PMID: 35746467; PMCID: PMC9229151.
  6. Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein JB, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG. A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. Nat Commun. 2022 Jun 17;13(1):3487. doi: 10.1038/s41467-022-31097-7. PMID: 35715395; PMCID: PMC9203258.
    News coverage: https://www.nature.com/articles/s41467-022-31097-7/metrics
    Selected as a Paper of the Year by NIH NIEHS: 
    https://factor.niehs.nih.gov/2023/1/science-highlights/papers-of-the-year
  7. Song X, Coulter FJ, Yang M, Smith JL, Tafesse FG, Messer WB, Reif JH. A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens. Sci Rep. 2022 Apr 29;12(1):7043. doi: 10.1038/s41598-022-11144-5. PMID: 35487969; PMCID: PMC9052177.
  8. Curlin ME, Bates TA, Guzman G, Schoen D, McBride SK, Carpenter SD, Tafesse FG. Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection. medRxiv [Preprint]. 2022 Apr 12:2022.04.11.22273694. doi: 10.1101/2022.04.11.22273694.
  9. Gelanew T, Seyoum B, Mulu A, Mihret A, Abebe M, Wassie L, Gelaw B, Sorsa A, Merid Y, Muchie Y, Teklemariam Z, Tesfaye B, Osman M, Jebessa G, Atinafu A, Hailu T, Habte A, Kenea D, Gadisa A, Admasu D, Tesfaye E, Bates TA, Bulcha JT, Tschopp R, Tsehay D, Mullholand K, Howe R, Genetu A, Tafesse FG, Abdissa A. High seroprevalence of anti-SARS-CoV-2 antibodies among Ethiopian healthcare workers. BMC Infect Dis. 2022 Mar 16;22(1):261. doi: 10.1186/s12879-022-07247-z. PMID: 35296265; PMCID: PMC8926102.
  10. Weinstein JB, Bates TA, Leier HC, McBride SK, Barklis E, Tafesse FG. A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants. iScience. 2022 Mar 18;25(3):103960. doi: 10.1016/j.isci.2022.103960. Epub 2022 Feb 22. PMID: 35224467; PMCID: PMC8863326.
  11. Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein J, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG. A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. bioRxiv [Preprint]. 2022 Feb 15:2022.02.14.480430. doi: 10.1101/2022.02.14.480430.
  12. Bates TA, McBride SK, Leier HC, Guzman G, Lyski ZL, Schoen D, Winders B, Lee JY, Lee DX, Messer WB, Curlin ME, Tafesse FG. Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants. Sci Immunol. 2022 Feb 18;7(68):eabn8014. doi: 10.1126/sciimmunol.abn8014. Epub 2022 Feb 18. PMID: 35076258; PMCID: PMC8939472.
    News coverage:
    OHSU:

    https://news.ohsu.edu/2022/01/25/new-study-suggests-two-paths-toward-super-immunity-to-covid-19
    Several others: https://immunology.altmetric.com/details/121556796/news
  13. van Breemen RB, Muchiri RN, Bates TA, Weinstein JB, Leier HC, Farley S, Tafesse FG. Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants. J Nat Prod. 2022 Jan 28;85(1):176-184. doi: 10.1021/acs.jnatprod.1c00946. Epub 2022 Jan 10. PMID: 35007072; PMCID: PMC8768006.
    News coverage (>400 news outlets): https://acs.altmetric.com/details/120597548/news
  14. Bates TA, McBride SK, Winders B, Schoen D, Trautmann L, Curlin ME, Tafesse FG. Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection. JAMA. 2022 Jan 11;327(2):179-181. doi: 10.1001/jama.2021.22898. PMID: 34914825; PMCID: PMC8678894.
    News coverage: Times: https://time.com/6171943/how-long-does-covid-immunity-last/
    Several others (>250 news outlets): https://time.com/6171943/how-long-does-covid-immunity-last/
  15. Lyski ZL, Brunton AE, Strnad MI, Sullivan PE, Siegel SAR, Tafesse FG, Slifka MK, Messer WB. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific Memory B Cells From Individuals With Diverse Disease Severities Recognize SARS-CoV-2 Variants of Concern. J Infect Dis. 2022 Mar 15;225(6):947-956. doi: 10.1093/infdis/jiab585. PMID: 34865053; PMCID: PMC8922005.

2021

  1. Bates TA#, Leier HC#, Lyski ZL, Goodman JR, Curlin ME, Messer WB, Tafesse FG. Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples. JAMA. 2021 Jul 21:e2111656. doi: 10.1001/jama.2021.11656. Epub ahead of print. PMID: 34287620; PMCID: PMC8295896
    News coverage: https://jamanetwork.altmetric.com/details/110100620/news
  2. Lyski ZL, Brunton AE, Strnad MI, Sullivan PE, Siegel SAR, Tafesse FG, Slifka MK, Messer WB. SARS-CoV-2 specific memory B-cells from individuals with diverse disease severities recognize SARS-CoV-2 variants of concern. medRxiv [Preprint]. 2021 Jun 3:2021.05.28.21258025. doi: 10.1101/2021.05.28.21258025.
  3. Leier HC, Bates TA, Lyski ZL, McBride SK, X Lee D, Coulter FJ, Goodman JR, Lu Z, Curlin ME, Messer WB, Tafesse FG. Previously infected vaccinees broadly neutralize SARS-CoV-2 variants. medRxiv [Preprint]. 2021 Apr 29:2021.04.25.21256049. doi: 10.1101/2021.04.25.21256049. PMID: 33948601; PMCID: PMC8095208.
  4. Bates TA, Leier HC, Lyski ZL, McBride SK, Coulter FJ, Weinstein JB, Goodman JR, Lu Z, Siegel SAR, Sullivan P, Strnad M, Brunton AE, Lee DX, Adey AC, Bimber BN, O'Roak BJ, Curlin ME*, Messer WB*, Tafesse FG*. Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum. Nature Communications. 2021 Aug 26;12(1):5135. doi: 10.1038/s41467-021-25479-6. PMID: 34446720.
    News coverage: https://www.nature.com/articles/s41467-021-25479-6/metrics
  5. Gelanew T, Seyoum B, Mulu A, Mihret A, Abebe M, Wassie L, Gelaw B, Sorsa A, Merid Y, Muchie Y, Teklemariam Z, Tesfaye B, Osman M, Jebessa G, Atinafu A, Hailu T, Habte A, Kenea D, Gadissa A, Admasu D, Tesfaye E, Bates TA, Bulcha J, Tschopp R, Tsehay D, Mullholand K, Howe R, Genetu A, Tafesse FG, Abdissa A. High Seroprevalence of Anti-SARS-CoV-2 Antibodies Among Ethiopian Healthcare Workers. Res Sq [Preprint]. 2021 Jul 19:rs.3.rs-676935. doi: 10.21203/rs.3.rs-676935/v1.
  6. Alfadhli A, Romanaggi C, Barklis RL, Merutka I, Bates TA, Tafesse FG*, Barklis E*. Capsid-specific nanobody effects on HIV-1 assembly and infectivity. Virology. 2021 Jul 5;562:19-28. doi: 10.1016/j.virol.2021.07.001. Epub ahead of print. PMID: 34246112.
  7. Bates TA#, Weinstein JB#, Farley S#, Leier HC, Messer WB, Tafesse FG. Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2. Cell Reports. 2021 Feb 16;34(7):108737. doi: 10.1016/j.celrep.2021.108737. PMID: 33545052; PMCID: PMC7835103.
  8. Barklis E*, Alfadhli A, Kyle JE, Bramer LM, Bloodsworth KJ, Barklis RL, Leier HC, Petty RM, Zelnik ID, Metz TO, Futerman AH, Tafesse FG*. Ceramide synthase 2 deletion decreases the infectivity of HIV-1. J Biological Chemistry. 2021 Jan-Jun;296:100340. doi: 10.1016/j.jbc.2021.100340. Epub 2021 Jan 28. PMID: 33515546; PMCID: PMC7949126.
  9. Niekamp P#, Guzman G#, Leier HC, Rashidfarrokhi A, Richina V, Pott F, Barisch C, Holthuis JCM*, Tafesse FG*. Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry. mBio. 2021 Jan 26;12(1):e03141-20. doi: 10.1128/mBio.03141-20. PMID: 33500344; PMCID: PMC7858061.

2020

  1. Bates TA, Weinstein JB, Farley SE, Leier HC, Messer WB, Tafesse FG. Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2. bioRxiv [Preprint]. 2020 Jul 30:2020.07.30.229377. doi: 10.1101/2020.07.30.229377.
  2. Huber ME, Kurapova R, Heisler CM, Karamooz E, Tafesse FG, Harriff MJ. Rab6 regulates recycling and retrograde trafficking of MR1 molecules. Scientific Reports. 2020 Nov 27;10(1):20778. doi: 10.1038/s41598-020-77563-4. PMID: 33247182; PMCID: PMC7699632.
  3. Narayanan GA, Nellore A, Tran J, Worley AH, Meermeier EW, Karamooz E, Huber ME, Kurapova R, Tafesse FG, Harriff MJ, Lewinsohn DM. Alternative splicing of MR1 regulates antigen presentation to MAIT cells. Scientific Reports. 2020 Sep 22;10(1):15429. doi: 10.1038/s41598-020-72394-9. PMID: 32963314; PMCID: PMC7508857.
  4. Leier HC, Weinstein JB, Kyle JE, Lee JY, Bramer LM, Stratton KG, Kempthorne D, Navratil AR, Tafesse EG, Hornemann T, Messer WB, Dennis EA, Metz TO, Barklis E, Tafesse FG. A global lipid map defines a network essential for Zika virus replication. Nature Communications. 2020 Jul 21;11(1):3652. doi: 10.1038/s41467-020-17433-9. PMID: 32694525; PMCID: PMC7374707.
  5. Guzman G, Niekamp P, Tafesse FG. The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi. J Fungi (Basel). 2020 Jan 31;6(1):19. doi: 10.3390/jof6010019. PMID: 32024011; PMCID: PMC7151219.
  6. Guzman G, Tafesse FG. Visualization and Quantification of Phagocytosis by Neutrophils. Methods Mol Biol. 2020;2087:141-148. doi: 10.1007/978-1-0716-0154-9_11. PMID: 31728989.

2019

  1. Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis. Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM.
    Nat Commun. 2019 May 27;10(1):2329. doi: 10.1038/s41467-019-10065-8.
    PMID: 31133636
  2. Sphingomyelin is critical in organizing phosphoinositide dynamics during phagocytic uptake of Mycobacterium tuberculosis. Patrick Niekamp, Gaelen Guzman, Hans Leier, Ali Rashidfarrokhi, Veronica Richina, Joost Holthuis, Fikadu G. Tafesse. Biorxiv. 2019. doi: https://doi.org/10.1101/565226
  3. Ceramides bind VDAC2 to trigger mitochondrial apoptosis. Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM. Nat Commun. 2019 Apr 23;10(1):1832. doi: 10.1038/s41467-019-09654-4

2018

  1. Lipids and pathogenic flaviviruses: An intimate union. Leier HC, Messer WB, Tafesse FG. PLoS Pathog. 2018 May 10;14(5):e1006952. doi: 10.1371/journal.ppat.1006952. PMID:29746606

2017

  1. Visualizing the early stages of phagocytosis. Rashidfarrokhi A, Richina V, Tafesse FG. J Vis Exp. 2017 Feb 3;(120). doi: 10.3791/54646. PMID: 28191879.
  2. Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK. The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent. Sci Rep. 2017 Dec 20;7(1):17916. doi: 10.1038/s41598-017-17948-0. PMID: 29263417; PMCID: PMC5738442.
  3. Cabukusta B, Nettebrock NT, Kol M, Hilderink A, Tafesse FG, Holthuis JCM. Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death. Biosci Rep. 2017 Jul 16;37(4):BSR20170867. doi: 10.1042/BSR20170867. PMID: 28659495; PMCID: PMC5567093.
  4. Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, Holthuis JCM. Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases. J Lipid Res. 2017 May;58(5):962-973. doi: 10.1194/jlr.M076133. Epub 2017 Mar 23. PMID: 28336574; PMCID: PMC5408615.

2016

  1. A functional role for antibodies in tuberculosis.
    Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G. Cell. 2016 Oct 6;167(2):433-43. doi: 10.1016/j.cell.2016.08.072. Epub 2016 Sept 22. PMID: 27667685
  2. Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.
    Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JG, Somerharju P, Korneev S, Tafesse FG, Holthuis JC. J Lipid Res. 2016 Jul;57(7):1273-85. doi: 10.1194/jlr.M068692. Epub 2016 May 10. PMID: 27165857
  3. Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E705-14. doi: 10.1073/pnas.1521763113. Epub 2016 Jan 25. PMID: 26811477; PMCID: PMC4760780.

2015 and older

  1. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.
    Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. PLoS Pathog.2015 Oct 2;11(10):e1005188. doi: 10.1371/journal.ppat.1005188. eCollection 2015 Oct. PMID: 26431038 
  2. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. 
    Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL. J Biol Chem. 2014 Aug 29;289(35):24005-18. doi: 10.1074/jbc.M114.589275. Epub 2014 Jul 16. PMID: 25031321
  3. Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.
    Tafesse FG, Vacaru AM, Bosma EF, Hermansson M, Jain A, Hilderink A, Somerharju P, Holthuis JC. J Cell Sci. 2014 Jan 15;127(Pt 2):445-54. doi: 10.1242/jcs.138933. Epub 2013 Nov 20. PMID: 24259670 
  4. Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.
    Tafesse FG, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P, Ploegh HL. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6406-11. doi: 10.1073/pnas.1219909110. Epub 2013 Apr 1. PMID: 23576732 
  5. Cell biology: A brake on lipid synthesis.
    Tafesse FG, Holthuis JC. Nature. 2010 Feb 25;463(7284):1028-9. doi: 10.1038/4631028a. No abstract available. PMID: 20182499
  6. Rietz S, Dermendjiev G, Oppermann E, Tafesse FG, Effendi Y, Holk A, Parker JE, Teige M, Scherer GF. Roles of Arabidopsis patatin-related phospholipases a in root development are related to auxin responses and phosphate deficiency. Mol Plant. 2010 May;3(3):524-38. doi: 10.1093/mp/ssp109. Epub 2010 Jan 6. PMID: 20053799.
  7. Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol. 2009 Jun 15;185(6):1013-27. doi: 10.1083/jcb.200903152. Epub 2009 Jun 8. PMID: 19506037; PMCID: PMC2711605.
  8. Tafesse FG, Huitema K, Hermansson M, van der Poel S, van den Dikkenberg J, Uphoff A, Somerharju P, Holthuis JC. Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J Biol Chem. 2007 Jun 15;282(24):17537-47. doi: 10.1074/jbc.M702423200. Epub 2007 Apr 22. PMID: 17449912.
  9. Tafesse FG, Ternes P, Holthuis JC. The multigenic sphingomyelin synthase family. J Biol Chem. 2006 Oct 6;281(40):29421-5. doi: 10.1074/jbc.R600021200. Epub 2006 Aug 11. PMID: 16905542.