Publications

Selected publications

2020 

A global lipid map defines a network essential for Zika virus replication
Hans C. Leier, Jules B. Weinstein, Jennifer E. Kyle, Joon-Yong Lee, Lisa M. Bramer, Kelly G. Stratton, Douglas Kempthorne, Aaron R. Navratil, Endala G. Tafesse, Thorsten Hornemann, William B. Messer, Edward A. Dennis, Thomas O. Metz, Eric Barklis, Fikadu G. Tafesse
Biorxiv. 2020. doi: https://doi.org/10.1101/2020.01.27.910919

Visualization and Quantification of Phagocytosis by Neutrophils.
Gaelen Guzman, and Fikadu Geta Tafesse
Methods Mol Biol. 2020;2087:141-148. doi: 10.1007/978-1-0716-0154-9_11.

The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi
Gaelen Guzman, Patrick Niekamp and Fikadu Geta Tafesse
Journal of Fungi, in press

2019

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis.
Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM.
Nat Commun. 2019 May 27;10(1):2329. doi: 10.1038/s41467-019-10065-8.
PMID: 31133636

Sphingomyelin is critical in organizing phosphoinositide dynamics during phagocytic uptake of Mycobacterium tuberculosis. 
Patrick Niekamp, Gaelen Guzman, Hans Leier, Ali Rashidfarrokhi, Veronica Richina, Joost Holthuis, Fikadu G. Tafesse. Biorxiv. 2019. doi: https://doi.org/10.1101/565226

Ceramides bind VDAC2 to trigger mitochondrial apoptosis. 
Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM. Nat Commun. 2019 Apr 23;10(1):1832. doi: 10.1038/s41467-019-09654-4

2018

Lipids and pathogenic flaviviruses: An intimate union.
Leier HC, Messer WB, Tafesse FG. PLoS Pathog. 2018 May 10;14(5):e1006952. doi: 10.1371/journal.ppat.1006952. PMID:29746606

2017

Visualizing the early stages of phagocytosis.
Rashidfarrokhi A, Richina V, Tafesse FG. J Vis Exp. 2017 Feb 3;(120). doi: 10.3791/54646. PMID: 28191879

2016

A functional role for antibodies in tuberculosis.
Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G. Cell. 2016 Oct 6;167(2):433-43. doi: 10.1016/j.cell.2016.08.072. Epub 2016 Sept 22. PMID: 27667685

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.
Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JG, Somerharju P, Korneev S, Tafesse FG, Holthuis JC. J Lipid Res. 2016 Jul;57(7):1273-85. doi: 10.1194/jlr.M068692. Epub 2016 May 10. PMID: 27165857

2015 and older

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.
Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. PLoS Pathog.2015 Oct 2;11(10):e1005188. doi: 10.1371/journal.ppat.1005188. eCollection 2015 Oct. PMID: 26431038 

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. 
Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL. J Biol Chem. 2014 Aug 29;289(35):24005-18. doi: 10.1074/jbc.M114.589275. Epub 2014 Jul 16. PMID: 25031321

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.
Tafesse FG, Vacaru AM, Bosma EF, Hermansson M, Jain A, Hilderink A, Somerharju P, Holthuis JC. J Cell Sci. 2014 Jan 15;127(Pt 2):445-54. doi: 10.1242/jcs.138933. Epub 2013 Nov 20. PMID: 24259670 

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.
Tafesse FG, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P, Ploegh HL. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6406-11. doi: 10.1073/pnas.1219909110. Epub 2013 Apr 1. PMID: 23576732 

Cell biology: A brake on lipid synthesis.
Tafesse FG, Holthuis JC. Nature. 2010 Feb 25;463(7284):1028-9. doi: 10.1038/4631028a. No abstract available. PMID: 20182499