Selected publications

New vistas in the biology of the flagellum – Leishmania parasites.
Landfear, S.M. Pathogens 11:447 (2022). doi: 10.3390/pathogens11040447. PMC9024700

A cytoskeletal protein complex is essential for division of intracellular amastigotes of Leishmania mexicana.
Kelly, F.D., Tran, K.D., Hatfield, J., Schmidt, K. Sanchez, M.A., and Landfear, S.M. J. Biol. Chem. 295:13106-13122 (2020). doi: 10.1074/jbc.RA120.014065. PMC7489907
Touching the surface: Diverse roles for the flagellar membrane in kinetoplastid parasites.
Kelly, F.D., Sanchez, M.A., and Landfear, S.M. Microbiol. Mol. Biol. Rev. 84:e00079-19 (2020). doi: 10.1128/MMBR.00079-19. 

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. 
Ortiz, D., Guiguemde, W.A., Hammill, J.T., Carrillo. A.K., Chen, Y., Connelly, M., Stalheim, K., Elya, C., Johnson, A., Min, J., Shelat, A., Smithson, D.C., Yang, L., Zhu, F., Guy, R.K., Landfear, S.M. PLoS Negl. Trop. Dis. 11:e0006157 (2017). doi: 10.1371/journal.pntd.0006157. PMC5764437

KHARON is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in African trypanosomes.
Sanchez, M., Tran, K.D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E., and Landfear. S.M. J. Biol. Chem., 2016 Sep 16;291(38):19760-73. doi: 10.1074/jbc.M116.739235. PMC5025667

Flagellar membrane proteins in kinetoplastid parasites.
Landfear SM, Tran KD, Sanchez MA.
IUBMB Life. 2015 Sep;67(9):668-76. doi: 10.1002/iub.1411. Review. PMC4662044

Kharon1 null mutants of Leishmania mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages.
Tran KD, Vieira DP, Sanchez MA, Valli J, Gluenz E, Landfear SM.
PLoS One. 2015 Aug 12;10(8):e0134432. doi: 10.1371/journal.pone.0134432.  PMC4534133

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds.
Ortiz, D., Guiguemde, W.A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R.K., and Landfear, S.M. PLoS One 10:e123598 (2015). doi: 10.1371journal.pone.0123598. PMC4404333

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor.
Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P.A., Kamhawi, S., and Landfear, S.M. FASEB Journal 29:11-24 (2015). doi.10.1096/fj.14-251991. PMC4285543

Transporters, channels and receptors in flagella.
Rodriguez-Contreras D, Landfear SM.Channels (Austin). 2014;8(6):477-8. doi: 10.4161/19336950.2014.985481. PMC4594579  

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes.
Tran, K.D., Rodriguez-Contreras, D., Vieira, D.P., Yates, P.A., David, L., Beatty, W., Elferich, J., and Landfear, S.M. J. Biol. Chem. 288:22721-22733 (2013). doi: 10.1074/jbc.M113.483461. PMC2376651