Selected publications

KHARON is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in African trypanosomes.
Sanchez, M., Tran, K.D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E., and Landfear. S.M. J. Biol. Chem., E-pub ahead of print (2016). 

Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.
Ortiz D, Forquer I, Boitz J, Soysa R, Elya C, Fulwiler A, Nilsen A, Polley T, Riscoe MK, Ullman B, Landfear SM.
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4972-82. doi: 10.1128/AAC.00850-16. Print 2016 Aug.
PMID: 27297476 

Flagellar membrane proteins in kinetoplastid parasites.
Landfear SM, Tran KD, Sanchez MA.
IUBMB Life. 2015 Sep;67(9):668-76. doi: 10.1002/iub.1411. Epub 2015 Aug 25. Review.
PMID: 26599841 

Kharon1 null mutants of Leishmania mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages.
Tran KD, Vieira DP, Sanchez MA, Valli J, Gluenz E, Landfear SM.
PLoS One. 2015 Aug 12;10(8):e0134432. doi: 10.1371/journal.pone.0134432. eCollection 2015.
PMID: 26266938 

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds.
Ortiz, D., Guiguemde, W.A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R.K., and Landfear, S.M. PLoS One 10:e123598 (2015) PMC4404333

Regulation and biological function of a flagellar glucose transporter in Leishmana mexicana: a potential glucose sensor.
Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P.A., Kamhawi, S., and Landfear, S.M. FASEB Journal 29:11-24 (2015) PMC4285543

Transporters, channels and receptors in flagella.
Rodriguez-Contreras D, Landfear SM.
Channels (Austin). 2014;8(6):477-8. doi: 10.4161/19336950.2014.985481. No abstract available.
PMID: 25485659  

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family.
Valdés, R., Elferich, J. Shinde, U., and Landfear. S.M. J. Biol. Chem. 289:8799-8809 (2014). PMC2670593

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes.
Tran, K.D., Rodriguez-Contreras, D., Vieira, D.P., Yates, P.A., David, L., Beatty, W., Elferich, J., and Landfear, S.M. J. Biol. Chem. 288:22721-22733 (2013) PMC2376651