Welcome to the Laura Heiser Lab

The research laboratory of Laura Heiser, Ph.D., is focused on identifying predictors of drug response and resistance, using novel imaging techniques to identify phenotypic changes associated with molecular aberrations and therapeutic response, and studying the influence of the microenvironment on cancer cells. In all of this research, the lab uses well-integrated experimental and computational approaches to understand the complexity of cancer. Because this work is necessarily multidisciplinary in nature, the lab frequently collaborate with diverse teams of scientists, as illustrated by involvement in the NIH LINCS Consortium, NCI Cancer Systems Biology Consortium (CSBC), and DREAM Project

Heiser Lab news

5/2022: Dr. Laura Heiser and collaborators receive OHSU Center for Women’s Health Circle of Giving Award

5/2022: Dr. Laura Heiser profiled for OHSU Research Week

4/2022: Nicholas Calistri won first place student poster award at MCBIOS 2022 for "Paclitaxel treatment partially phenocopies interferon response in Triple Negative Breast Cancer, and uniquely upregulated genes implicate potential adaptive resistance mechanisms"

1/2022: New grants awarded:

  • R03 in collaboration with Noemi Andor, Ph.D., Moffitt Cancer Center, titled, “A framework to integrate live-cell imaging with single-cell sequencing and learn how cells adapt to new environments”
  • Discovery Grant for Cancer Research funded by the Kuni Foundation in collaboration with Zahi Mitri, MD (OHSU), titled, “A preclinical approach to targeting cell state in aggressive metastatic breast cancer”

9/2021: Nicholas Calistri won a poster award at the NCI CSBC/PS-ON/BD-STEP Junior Investigator Meeting for his presentation showing that paclitaxel activates innate immunity and alters tumor-stromal interactions

Recent publications

Gross SM, Mohammadi F, Sanchez-Aguila C, Zhan PJ, Meyer AS, Heiser LM. Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects. bioRxiv. doi: https://doi.org/10.1101/2020.07.24.219907

Gross SM, Dane MA, … Heiser LM. A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses. bioRxiv. 2021:2021.08.06.455429. https://doi.org/10.1101/2021.08.06.455429

Mohammadi F, Visagan S, Gross SM, Karginov L, Lagarde J, Heiser LM, Meyer AS. A lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity. bioRxiv. 2021:2021.06.25.449922. https://doi.org/10.1101/2021.06.25.449922

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