Selected publications

Myeloid cells orchestrate systemic immunosuppression that impairs the efficacy of therapeutic vaccination and masks the effects of immunotherapy against HPV+ cancers.
Galliverti G, Wullschleger S, Tichet M Murugan D, Zangger N, Horton W, Korman A,
Galliverti G, Wullschleger S, Tichet M Murugan D, Zangger N, Horton W, Korman A, Coussens LM, Swartz MA, Hanahan D.Swartz MA, Hanahan D. (2020) 
Can Immuno Res. 8(1):131-145.
PMID: 31771984.

Safety, survival, and immune response with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines with and without Nivolumab for metastatic pancreatic.
Tsujikawa T, Crocenzi T, Durham JN, Sugar E, Wu A, Onners B, Nauroth JN, Anders RA, Fertig EJ, Lahreru DA, Reiss KA, Vonderheide RH, KO AH, Tempero MA, Fisher GA, Considine M, Danilova L, Brockstedt DG, Coussens LM, Jaffee EM, Le DT. (2020) Clin Can Res. 26(14):3578-3588.
PMID: 32273276.

Tumor-associated macrophages drive stromal cell-dependent collagen cross-linking and stiffening to promote breast cancer aggression.
Maller O, Drain AP, Barrett AS, Borquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM. (2020) Nature Materials. 2020 Nov 30. doi: 10.1038/s41563-020-00849-5. Online ahead of print.
PMID: 33257795

High-dimensional multiplexed immunohistochemistry characterization of immune contexture in human cancer.
Banik G, Betts CB, Liudahl S, Sigagnanam S, Kawashima R, Cotechini T, Larson W, Pai SI, Clayburgh DR, Goeks J, Tsujikawa T, Coussens LM. (2019) Methods Enz., in press. doi: 10.1016/bs.mie.2019.05.039

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
Casetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, Soong D, Cotechini T, Anur P, Lin E, Fidanza A, Yrigoyen ML, Millar MR, Urman A, Ai Z, Spellman P, Hwang ES, Dixon JM, Wiechmann L, Coussens LM, Smith HW, Pollard JW.
Cancer Cell, 35: 588-602. doi: 10.1016/j.ccell.2019.02.009.
PMID: 30930117

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Keklikoglou I, Cianciaruso C, Guc E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassara A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain R, Pollard JW, De Palma M. (2018) Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biology, 21(2): 190-202
PMID: 30598531

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity.
Tsujikawa T, Thibault G, Azimi V, Sivagnanam, Banik G, Means C, Kawashima R, Clayburgh DR, Gray JW, Coussens LM, Chang YH.
Cytometry. 95(4): 389-398. doi: 10.1002/cyto.a.23726.
PMID: 30714674

Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status.
Means C, Clayburgh DR, Maloney L, Sauer D, Taylor M, Shindo M, Coussens LM, Tsujikawa T.
Head & Neck, 1-11. doi: 10.1002/hed.25740.
PMID: 30896061

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo HS, Krummel MF, Coussens LM, Ruffell B.
Cancer Cell. 2018 Jan 8;33(1):60-74.e6. doi: 10.1016/j.ccell.2017.11.019.
PMID: 29316433

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Medler TR, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin M, Margolin AA, Werb Z, Coussens LM.
Cancer Cell. 2018 Oct 8;34(4):561-578.e6. doi: 10.1016/j.ccell.2018.09.003.
PMID: 30300579

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis.
Tsujikawa T, Kumar S, Borkar RN, Azimi V, Thibault G, Chang YH, Balter A, Kawashima R, Choe G, Sauer D, El Rassi E, Clayburgh DR, Kulesz-Martin MF, Lutz ER, Zheng L, Jaffee EM, Leyshock P, Margolin AA, Mori M, Gray JW, Flint PW, Coussens LM. (2017) Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis. Cell Reports, 19:203-217. PMID:28380359

Bruton’s tyrosine kinase (BTK)-dependent immune cell crosstalk drives pancreas cancer.
Gunderson AJ, Kaneda M, Tsujikawa T, Affara NI, Nguyen, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero M, Sheppard B, Irving B, Varner JA, Coussens LM. (2016) Cancer Discovery, 6(3): 270-285.

The basis of oncoimmunology.
Palucka AK, Coussens LM. (2016) Cell, 164(6):1233-1247.

Alk5-inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors.
Daldrup-Link HE, Mohanty S, Ansari C, Lenkov O, Shaw A, Ito K, Hong SH, Hoffman M, Pisani L, Boudreau N, Gambhir SS, Coussens LM.  (2016) J Clin Invest Insight. 1(6):e85608.

Immune response to cancer therapy: Mounting an effective antitumor response and mechanisms of resistance.
Medler TR, Cotechini T, Coussens LM. (2015) Trends in Cancer. 1:66-75.

TH2-polarized CD4+ T cells and macrophages limit efficacy of radiotherapy.
Shiao S, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. (2015) Can Immuno Res. 3(5):518-525. PMID: 25716473.

Macrophages and therapeutic resistance in cancer.
Ruffell B, Coussens LM. (2015) Cancer Cell. 27(4):462-472. PMID:25828805.

Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Ruffell B, Chang-Strachan D, Chan V, Rosenbusch A, Ho CMT, Pryer N, Daniel D, Hwang SE, Rugo HS, Coussens LM. (2014) Cancer Cell, 26:623-637.

Duality of the immune response in cancer: Lessons learned from skin.
Medler TR, Coussens LM. (2014) J Invest Dermatol. 134:E23-28.

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas.
Affara NI, Ruffell B, Medler TR, Gunderson AJ, Johansson M, Bornstein S, Bergsland E, Steinhoff M, Li Y, Gong Q, Ma Y, Wiesen JF, Wong MH, Kulesz-Martin M, Irving B, Coussens LM. (2014) Cancer Cell. 25 (6), 809-21.s.

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
Ruffell B, Affara NI, Cottone L, Junankar, S, Johansson M, DeNardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM. (2013) Genes Dev. 27(19): 2086-2098.

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cells responses to lung adenocarcinoma.
Ganessan AP, Johanson M, Ruffell B, Beltran A, Lau J, Jablons DM, Coussens LM. (2013) J Immunology, 191(4):2009-2017.

B cells and their mediators as targets for therapy in solid tumors.
Gunderson AG, Coussens LM (2013) Exp Cell Res. 319, 1644-1649.

Neutralizing tumor-promoting chronic inflammation: A magic bullet?
Coussens LM, Zitvogel L, Palucka AK. (2013) Science. 339, 286-291.

Accessories to the crime: Functions of cells recruited to the tumor microenvironment.
Hanahan D, Coussens LM. (2012) Cancer Cell. 21(3), 309-322.

Leukocyte complexity in human breast cancer.
Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM. (2012) Proc. Natl. Acad. Sci. 109, 2796-2801.

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
Denardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirström K, West BL, Coussens LM. (2011) Cancer Discov. 1:54-67.

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, Naldini L, de Visser KE, De Palma M, Coussens LM. (2010) Cancer Cell. 17(2):121-34.

CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. (2009) Cancer Cell. 16(2):91-102.